SPX3_MOUSE
ID SPX3_MOUSE Reviewed; 494 AA.
AC Q3TIT8; Q4FZD9; Q8BVX2;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 25-MAY-2022, entry version 98.
DE RecName: Full=Sugar phosphate exchanger 3;
DE AltName: Full=Solute carrier family 37 member 3;
GN Name=Slc37a3; Synonyms=Spx3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Head, and Placenta;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=NMRI; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:Q8NCC5}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family. {ECO:0000305}.
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DR EMBL; AK076213; BAC36258.1; -; mRNA.
DR EMBL; AK167716; BAE39758.1; -; mRNA.
DR EMBL; BC099673; AAH99673.1; -; mRNA.
DR CCDS; CCDS20020.1; -.
DR RefSeq; NP_082399.3; NM_028123.3.
DR RefSeq; XP_017177246.1; XM_017321757.1.
DR RefSeq; XP_017177247.1; XM_017321758.1.
DR RefSeq; XP_017177248.1; XM_017321759.1.
DR AlphaFoldDB; Q3TIT8; -.
DR SMR; Q3TIT8; -.
DR STRING; 10090.ENSMUSP00000087709; -.
DR GlyGen; Q3TIT8; 1 site.
DR PaxDb; Q3TIT8; -.
DR PRIDE; Q3TIT8; -.
DR ProteomicsDB; 261644; -.
DR DNASU; 72144; -.
DR GeneID; 72144; -.
DR KEGG; mmu:72144; -.
DR UCSC; uc009bll.2; mouse.
DR CTD; 84255; -.
DR MGI; MGI:1919394; Slc37a3.
DR eggNOG; KOG2533; Eukaryota.
DR InParanoid; Q3TIT8; -.
DR OrthoDB; 964162at2759; -.
DR PhylomeDB; Q3TIT8; -.
DR TreeFam; TF314991; -.
DR BioGRID-ORCS; 72144; 3 hits in 73 CRISPR screens.
DR ChiTaRS; Slc37a3; mouse.
DR PRO; PR:Q3TIT8; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q3TIT8; protein.
DR GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; ISS:UniProtKB.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR000849; Sugar_P_transporter.
DR Pfam; PF07690; MFS_1; 1.
DR PIRSF; PIRSF002808; Hexose_phosphate_transp; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Glycoprotein; Membrane; Reference proteome;
KW Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..494
FT /note="Sugar phosphate exchanger 3"
FT /id="PRO_0000309279"
FT TRANSMEM 10..30
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..101
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..166
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 177..197
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 209..229
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 297..317
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 333..353
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 357..377
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 386..406
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 428..448
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 457..477
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 240..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 244..258
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 58
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 197
FT /note="A -> T (in Ref. 2; AAH99673)"
FT /evidence="ECO:0000305"
FT CONFLICT 237
FT /note="P -> L (in Ref. 2; AAH99673)"
FT /evidence="ECO:0000305"
FT CONFLICT 369
FT /note="W -> G (in Ref. 1; BAC36258 and 2; AAH99673)"
FT /evidence="ECO:0000305"
FT CONFLICT 473
FT /note="L -> S (in Ref. 2; AAH99673)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 494 AA; 54553 MW; 1343CBFC34C192F5 CRC64;
MAWPRFLQRG ALLTSFSHHH LAVFLLTFFS YSLLHASRKT FSNVKVSISK QWTPNAFNTS
LDLPAEIWSS NHLFPSTEEA TLFLGTLDTV FLFSYAVGLF ISGIIGDRLN LRWVLSFGMC
SSAFVVFVFG TLTEWLHFYN KWFYCGLWIV NGLLQSTGWP CVVAVMGNWF GKAGRGVVFG
LWSACASVGN ILGAFLASSV LQYGYEYAFL VTASVQFAGG IIIFFGLLVS PEEIGLPSIG
AEESSEEDSQ RPLIDGAENE DDYEPNYSIQ EDRAVVQVKA ISFHQACCLP GVIPYSLAYA
CLKLVNYSFF FWLPFYLSNN FGWKEAEADK LSIWYDVGGI IGGTLLGFIS DVLQKRAPVL
ALSLFLAVWS LVGYSRSPNN KSINALLMTI TGFFIGGPSN MVSSAISADL GRQELIQGNS
EALATVTGIV DGTGSIGAAV GQYLVSLIQD NLGWMWVFYF FILMTSCTIL FILPLIVREV
FSLVQRRQAH SLNE
