ID   SPX3_XENLA              Reviewed;         503 AA.
AC   Q640L2;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Sugar phosphate exchanger 3;
DE   AltName: Full=Solute carrier family 37 member 3;
GN   Name=slc37a3; Synonyms=spx3;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q8NCC5}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family. {ECO:0000305}.
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DR   EMBL; BC082612; AAH82612.1; -; mRNA.
DR   RefSeq; NP_001082192.1; NM_001088723.1.
DR   AlphaFoldDB; Q640L2; -.
DR   SMR; Q640L2; -.
DR   DNASU; 398284; -.
DR   GeneID; 398284; -.
DR   KEGG; xla:398284; -.
DR   CTD; 398284; -.
DR   Xenbase; XB-GENE-995747; slc37a3.L.
DR   OrthoDB; 964162at2759; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 398284; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR000849; Sugar_P_transporter.
DR   Pfam; PF07690; MFS_1; 1.
DR   PIRSF; PIRSF002808; Hexose_phosphate_transp; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Glycoprotein; Membrane; Reference proteome;
KW   Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..503
FT                   /note="Sugar phosphate exchanger 3"
FT                   /id="PRO_0000309281"
FT   TRANSMEM        20..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        119..139
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        152..172
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        183..203
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        214..234
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        300..322
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        342..362
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        367..387
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        395..415
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        437..457
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        466..486
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        62
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        71
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        275
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   503 AA;  55600 MW;  DCA28082D542A336 CRC64;
     MDFPVNTRRM AGRRGFFSQY THHHLAAFLL TFFSYSLLHA SRKSFSNVKV SVSSQWTPSD
     LNSSAYIVLP NETWNGNTLF PNTKSATLFL GLLDTIFLFA YAVGLFISGI IGDRLNMRLV
     LTFGMCSSAI TMFVFGTLTE WLQFYNKIFY CLVWIVNGLL QSTGWPCVVA IMGNWFGKSG
     RGFVFGLWSA CASVGNILGA FLASSVLKYG YEYAFLVTAS VQFAGGIIIF FGLVTSPKEL
     GLPDTGEGEM DRAAQEEGAN KPLIGGNDEG DDESNYSIQS DDVVITPKAI GFMQACCLPG
     VLLYSLAYAC LKLVNYSFFF WLPYYLSNNF KWKEAEADQL SIWYDIGGIV GGTVQGLISD
     LMKMRSPVLT VSLLLAVGAL FGYSHSPNDK VMNAFIMSIT GFFIGGPSNM ISSAISADLG
     RQEMVRGSSE ALATVTGIVD GTGSIGAAMG QFLVPLIQNS LNWMWVFYFF IFMICMTTVF
     MVPLIVRETR DWLRQRRSSR LER