SPX4_ARATH
ID SPX4_ARATH Reviewed; 318 AA.
AC Q94A21; Q9LXE9;
DT 05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 25-MAY-2022, entry version 92.
DE RecName: Full=SPX domain-containing protein 4;
DE AltName: Full=Protein SPX DOMAIN GENE 4;
DE Short=AtSPX4;
GN Name=SPX4; OrderedLocusNames=At5g15330; ORFNames=F8M21_220;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Shinn P., Chen H., Cheuk R.F., Kim C.J., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY.
RX PubMed=18315545; DOI=10.1111/j.1365-313x.2008.03460.x;
RA Duan K., Yi K., Dang L., Huang H., Wu W., Wu P.;
RT "Characterization of a sub-family of Arabidopsis genes with the SPX domain
RT reveals their diverse functions in plant tolerance to phosphorus
RT starvation.";
RL Plant J. 54:965-975(2008).
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB89343.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AL353993; CAB89343.1; ALT_INIT; Genomic_DNA.
DR EMBL; CP002688; AED92150.1; -; Genomic_DNA.
DR EMBL; AY050440; AAK91456.1; -; mRNA.
DR EMBL; BT020408; AAV97799.1; -; mRNA.
DR PIR; T49968; T49968.
DR RefSeq; NP_001330175.1; NM_001343398.1.
DR RefSeq; NP_568312.1; NM_121537.3.
DR AlphaFoldDB; Q94A21; -.
DR SMR; Q94A21; -.
DR BioGRID; 16662; 7.
DR IntAct; Q94A21; 7.
DR STRING; 3702.AT5G15330.1; -.
DR PaxDb; Q94A21; -.
DR PRIDE; Q94A21; -.
DR ProteomicsDB; 228318; -.
DR EnsemblPlants; AT5G15330.1; AT5G15330.1; AT5G15330.
DR GeneID; 831385; -.
DR Gramene; AT5G15330.1; AT5G15330.1; AT5G15330.
DR KEGG; ath:AT5G15330; -.
DR Araport; AT5G15330; -.
DR TAIR; locus:2150921; AT5G15330.
DR eggNOG; KOG1161; Eukaryota.
DR HOGENOM; CLU_057600_0_0_1; -.
DR InParanoid; Q94A21; -.
DR OMA; AAMRTIQ; -.
DR OrthoDB; 1345784at2759; -.
DR PhylomeDB; Q94A21; -.
DR PRO; PR:Q94A21; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q94A21; baseline and differential.
DR Genevisible; Q94A21; AT.
DR GO; GO:0005829; C:cytosol; IDA:TAIR.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0016036; P:cellular response to phosphate starvation; IEP:TAIR.
DR GO; GO:0055062; P:phosphate ion homeostasis; IMP:TAIR.
DR InterPro; IPR004331; SPX_dom.
DR InterPro; IPR031142; SPX_prot.
DR PANTHER; PTHR45978; PTHR45978; 1.
DR PANTHER; PTHR45978:SF7; PTHR45978:SF7; 1.
DR Pfam; PF03105; SPX; 3.
DR PROSITE; PS51382; SPX; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..318
FT /note="SPX domain-containing protein 4"
FT /id="PRO_0000398345"
FT DOMAIN 1..187
FT /note="SPX"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00714"
FT REGION 226..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 284..318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 284..303
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 304..318
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 318 AA; 36036 MW; 2BB70F3B7CCBCBB7 CRC64;
MKFGKEFRTH LEETLPEWRD KFLCYKPLKK LLKYYPYYSA DFGPANSDHN DSRPVFADTT
NISSAADDGG VVPGVRPSED LQGSFVRILN DELEKFNDFY VDKEEDFVIR LQELKERIEQ
VKEKNGEFAS ESEFSEEMMD IRRDLVTIHG EMVLLKNYSS LNFAGLVKIL KKYDKRTGGL
LRLPFTQLVL HQPFFTTEPL TRLVRECEAN LELLFPSEAE VVESSSAVQA HSSSHQHNSP
RISAETSSTL GNENLDIYKS TLAAMRAIRG LQKASSTYNP LSFSSLLQNE DDETVTAENS
PNSGNKDDSE KEDTGPSH
