ID   SPXH_BACCZ              Reviewed;         297 AA.
AC   Q63EH0;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=ClpXP adapter protein SpxH {ECO:0000255|HAMAP-Rule:MF_02245};
GN   Name=spxH {ECO:0000255|HAMAP-Rule:MF_02245}; OrderedLocusNames=BCE33L1091;
OS   Bacillus cereus (strain ZK / E33L).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=288681;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ZK / E33L;
RX   PubMed=16621833; DOI=10.1128/jb.188.9.3382-3390.2006;
RA   Han C.S., Xie G., Challacombe J.F., Altherr M.R., Bhotika S.S., Bruce D.,
RA   Campbell C.S., Campbell M.L., Chen J., Chertkov O., Cleland C.,
RA   Dimitrijevic M., Doggett N.A., Fawcett J.J., Glavina T., Goodwin L.A.,
RA   Hill K.K., Hitchcock P., Jackson P.J., Keim P., Kewalramani A.R.,
RA   Longmire J., Lucas S., Malfatti S., McMurry K., Meincke L.J., Misra M.,
RA   Moseman B.L., Mundt M., Munk A.C., Okinaka R.T., Parson-Quintana B.,
RA   Reilly L.P., Richardson P., Robinson D.L., Rubin E., Saunders E., Tapia R.,
RA   Tesmer J.G., Thayer N., Thompson L.S., Tice H., Ticknor L.O., Wills P.L.,
RA   Brettin T.S., Gilna P.;
RT   "Pathogenomic sequence analysis of Bacillus cereus and Bacillus
RT   thuringiensis isolates closely related to Bacillus anthracis.";
RL   J. Bacteriol. 188:3382-3390(2006).
CC   -!- FUNCTION: Adapter protein required for efficient degradation of Spx by
CC       ClpXP under non-stress conditions. Interaction with Spx stabilizes Spx
CC       and exposes the C-terminus of Spx for recognition and proteolysis by
CC       ClpXP. {ECO:0000255|HAMAP-Rule:MF_02245}.
CC   -!- SUBUNIT: Interacts with Spx. {ECO:0000255|HAMAP-Rule:MF_02245}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_02245}.
CC   -!- SIMILARITY: Belongs to the SpxH family. {ECO:0000255|HAMAP-
CC       Rule:MF_02245}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000001; AAU19155.1; -; Genomic_DNA.
DR   RefSeq; WP_000360666.1; NZ_CP009968.1.
DR   AlphaFoldDB; Q63EH0; -.
DR   SMR; Q63EH0; -.
DR   EnsemblBacteria; AAU19155; AAU19155; BCE33L1091.
DR   KEGG; bcz:BCE33L1091; -.
DR   PATRIC; fig|288681.22.peg.4472; -.
DR   OMA; YRMGGLL; -.
DR   Proteomes; UP000002612; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   HAMAP; MF_02245; Adapter_SpxH; 1.
DR   InterPro; IPR046404; Adapter_SpxH.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   SUPFAM; SSF52833; SSF52833; 1.
PE   3: Inferred from homology;
KW   Cytoplasm.
FT   CHAIN           1..297
FT                   /note="ClpXP adapter protein SpxH"
FT                   /id="PRO_0000278677"
SQ   SEQUENCE   297 AA;  34340 MW;  81F26CA6CA24D7E8 CRC64;
     MDKQEAKHIN MPSPSTCEHK SVEAYLFIDP LCKDCWEIEP FIIKLWLEYG KYFSIRHIVT
     GKVDGTNASS HKWNKPANIR FVWEKTTSLH GFSCDGKVHM QEASSTPYLV SMAIKAAELQ
     GRKAGSKFLR KLQEYIFLEN VSNPDCELLL ACAKDSDIDV EEFKKDLYSA SAKKAFQCDL
     KFTNEMHITE IPSLVFFHAN SDEEGIKIAG TYSYDVYVQL LKELVKCEIE PEPLPPLEVL
     LEATQFISSK EVAFIYDCSK QEIERELKKL QLKRKVQMID VKCERYWKWI AKEKDLV