ID   SPXH_STAA3              Reviewed;         268 AA.
AC   Q2FI75;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=ClpXP adapter protein SpxH {ECO:0000255|HAMAP-Rule:MF_02245};
GN   Name=spxH {ECO:0000255|HAMAP-Rule:MF_02245};
GN   OrderedLocusNames=SAUSA300_0903;
OS   Staphylococcus aureus (strain USA300).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=367830;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=USA300;
RX   PubMed=16517273; DOI=10.1016/s0140-6736(06)68231-7;
RA   Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G.,
RA   Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F.,
RA   Perdreau-Remington F.;
RT   "Complete genome sequence of USA300, an epidemic clone of community-
RT   acquired meticillin-resistant Staphylococcus aureus.";
RL   Lancet 367:731-739(2006).
CC   -!- FUNCTION: Adapter protein required for efficient degradation of Spx by
CC       ClpXP under non-stress conditions. Interaction with Spx stabilizes Spx
CC       and exposes the C-terminus of Spx for recognition and proteolysis by
CC       ClpXP. {ECO:0000255|HAMAP-Rule:MF_02245}.
CC   -!- SUBUNIT: Interacts with Spx. {ECO:0000255|HAMAP-Rule:MF_02245}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_02245}.
CC   -!- SIMILARITY: Belongs to the SpxH family. {ECO:0000255|HAMAP-
CC       Rule:MF_02245}.
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DR   EMBL; CP000255; ABD21733.1; -; Genomic_DNA.
DR   RefSeq; WP_000896697.1; NZ_CP027476.1.
DR   AlphaFoldDB; Q2FI75; -.
DR   SMR; Q2FI75; -.
DR   PRIDE; Q2FI75; -.
DR   EnsemblBacteria; ABD21733; ABD21733; SAUSA300_0903.
DR   KEGG; saa:SAUSA300_0903; -.
DR   HOGENOM; CLU_069785_0_0_9; -.
DR   OMA; YRMGGLL; -.
DR   Proteomes; UP000001939; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   HAMAP; MF_02245; Adapter_SpxH; 1.
DR   InterPro; IPR046404; Adapter_SpxH.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   SUPFAM; SSF52833; SSF52833; 1.
PE   3: Inferred from homology;
KW   Cytoplasm.
FT   CHAIN           1..268
FT                   /note="ClpXP adapter protein SpxH"
FT                   /id="PRO_0000278688"
SQ   SEQUENCE   268 AA;  31364 MW;  F40B877860BD1140 CRC64;
     MAGELRIMEN KSREDINLSP VSKIEIYSFF DPFSSDCFKL SAILSKLRIE YNQYIRIRHI
     LNPSLKVLTK CQAQSTSNFD NIALAYKAAE LQGRVRAERF IHLMQNEIIP KRDIITESMI
     CDCIQNAGID LEVFKDDLQK SKLTESLKID LHIAREMEIE QAPSLVFFSE DVHEEGLKVE
     GLYPYHIYTY IINELMGKPI EKNLPPKLET YIQQQQLVTM EELLTIYEWP EKLLNKELKK
     LAIQQKIEKL KYPDGDFWKS KMPKIKSK