ID   SPXH_STAAC              Reviewed;         268 AA.
AC   Q5HH83;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=ClpXP adapter protein SpxH {ECO:0000255|HAMAP-Rule:MF_02245};
GN   Name=spxH {ECO:0000255|HAMAP-Rule:MF_02245}; OrderedLocusNames=SACOL1006;
OS   Staphylococcus aureus (strain COL).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93062;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=COL;
RX   PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA   Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA   Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA   Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA   Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA   Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA   Fraser C.M.;
RT   "Insights on evolution of virulence and resistance from the complete genome
RT   analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT   a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT   strain.";
RL   J. Bacteriol. 187:2426-2438(2005).
CC   -!- FUNCTION: Adapter protein required for efficient degradation of Spx by
CC       ClpXP under non-stress conditions. Interaction with Spx stabilizes Spx
CC       and exposes the C-terminus of Spx for recognition and proteolysis by
CC       ClpXP. {ECO:0000255|HAMAP-Rule:MF_02245}.
CC   -!- SUBUNIT: Interacts with Spx. {ECO:0000255|HAMAP-Rule:MF_02245}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_02245}.
CC   -!- SIMILARITY: Belongs to the SpxH family. {ECO:0000255|HAMAP-
CC       Rule:MF_02245}.
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DR   EMBL; CP000046; AAW36474.1; -; Genomic_DNA.
DR   RefSeq; WP_000896699.1; NC_002951.2.
DR   AlphaFoldDB; Q5HH83; -.
DR   SMR; Q5HH83; -.
DR   EnsemblBacteria; AAW36474; AAW36474; SACOL1006.
DR   KEGG; sac:SACOL1006; -.
DR   HOGENOM; CLU_069785_0_0_9; -.
DR   OMA; YRMGGLL; -.
DR   Proteomes; UP000000530; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   HAMAP; MF_02245; Adapter_SpxH; 1.
DR   InterPro; IPR046404; Adapter_SpxH.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   SUPFAM; SSF52833; SSF52833; 1.
PE   3: Inferred from homology;
KW   Cytoplasm.
FT   CHAIN           1..268
FT                   /note="ClpXP adapter protein SpxH"
FT                   /id="PRO_0000278691"
SQ   SEQUENCE   268 AA;  31392 MW;  D642BAC43DC24A9A CRC64;
     MAGELRIMEN KSREDINLSP VSKIEIYSFF DPFSSDCFKL SAILSKLRIE YNQYIRIRHI
     LNPSLKVLTK CQAQSTSNFD NIALAYKAAE LQGRVRVERF IHLMQNEIIP KRDIITESMI
     CDCIQNAGID LEVFKDDLQK SKLTESLKID LHIAREMEIE QAPSLVFFSE DVHEEGLKVE
     GLYPYHIYTY IINELMGKPI EKNLPPKLET YIQQQQLVTM EELLTIYEWP EKLLNKELKK
     LAIQQKIEKL KYPDGDFWKS KMPKIKSK