ID   SPXH_STAAM              Reviewed;         268 AA.
AC   Q931V3; Q7WRM0; Q7X225;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 3.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=ClpXP adapter protein SpxH {ECO:0000255|HAMAP-Rule:MF_02245};
GN   Name=spxH {ECO:0000255|HAMAP-Rule:MF_02245}; OrderedLocusNames=SAV1001;
OS   Staphylococcus aureus (strain Mu50 / ATCC 700699).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=158878;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mu50 / ATCC 700699;
RX   PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA   Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA   Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA   Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA   Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA   Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA   Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA   Hiramatsu K.;
RT   "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL   Lancet 357:1225-1240(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 8-268.
RX   PubMed=14729744; DOI=10.1093/jac/dkh086;
RA   Wootton M., Avison M.B., Bennett P.M., Howe R.A., MacGowan A.P.,
RA   Walsh T.R.;
RT   "Genetic analysis of 17 genes in Staphylococcus aureus with reduced
RT   susceptibility to vancomycin (VISA) and heteroVISA.";
RL   J. Antimicrob. Chemother. 53:406-407(2004).
CC   -!- FUNCTION: Adapter protein required for efficient degradation of Spx by
CC       ClpXP under non-stress conditions. Interaction with Spx stabilizes Spx
CC       and exposes the C-terminus of Spx for recognition and proteolysis by
CC       ClpXP. {ECO:0000255|HAMAP-Rule:MF_02245}.
CC   -!- SUBUNIT: Interacts with Spx. {ECO:0000255|HAMAP-Rule:MF_02245}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_02245}.
CC   -!- SIMILARITY: Belongs to the SpxH family. {ECO:0000255|HAMAP-
CC       Rule:MF_02245}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB57163.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BA000017; BAB57163.2; ALT_INIT; Genomic_DNA.
DR   EMBL; AJ564070; CAD91854.1; -; Genomic_DNA.
DR   RefSeq; WP_000896697.1; NC_002758.2.
DR   AlphaFoldDB; Q931V3; -.
DR   SMR; Q931V3; -.
DR   PaxDb; Q931V3; -.
DR   EnsemblBacteria; BAB57163; BAB57163; SAV1001.
DR   KEGG; sav:SAV1001; -.
DR   HOGENOM; CLU_069785_0_0_9; -.
DR   OMA; YRMGGLL; -.
DR   BioCyc; SAUR158878:SAV_RS05415-MON; -.
DR   Proteomes; UP000002481; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   HAMAP; MF_02245; Adapter_SpxH; 1.
DR   InterPro; IPR046404; Adapter_SpxH.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   SUPFAM; SSF52833; SSF52833; 1.
PE   3: Inferred from homology;
KW   Cytoplasm.
FT   CHAIN           1..268
FT                   /note="ClpXP adapter protein SpxH"
FT                   /id="PRO_0000278692"
SQ   SEQUENCE   268 AA;  31364 MW;  F40B877860BD1140 CRC64;
     MAGELRIMEN KSREDINLSP VSKIEIYSFF DPFSSDCFKL SAILSKLRIE YNQYIRIRHI
     LNPSLKVLTK CQAQSTSNFD NIALAYKAAE LQGRVRAERF IHLMQNEIIP KRDIITESMI
     CDCIQNAGID LEVFKDDLQK SKLTESLKID LHIAREMEIE QAPSLVFFSE DVHEEGLKVE
     GLYPYHIYTY IINELMGKPI EKNLPPKLET YIQQQQLVTM EELLTIYEWP EKLLNKELKK
     LAIQQKIEKL KYPDGDFWKS KMPKIKSK