ID   SPXH_STAAU              Reviewed;         261 AA.
AC   P0C5Z9; P0C2H5; Q7WRM0; Q7X225;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   03-AUG-2022, entry version 35.
DE   RecName: Full=ClpXP adapter protein SpxH {ECO:0000255|HAMAP-Rule:MF_02245};
DE   Flags: Fragment;
GN   Name=spxH {ECO:0000255|HAMAP-Rule:MF_02245};
OS   Staphylococcus aureus.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=1280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=FranceDuf, Glasgow3700, Glasgow3759, LIM1, LIM2, LIM3, LiverpoolAG,
RC   LLA, LLE, Michigan, New Jersey, Norway1018, PC1, PC3, Slovenia6096,
RC   SMH10501, SMH11888, SMH12248, SMH14017, SMH17487, SMH17608, SMH18000,
RC   SMH18034, SMH18037, SMH2, SMH8997, Southampton23, St. Luke, Sweden307, and
RC   Sweden309;
RX   PubMed=14729744; DOI=10.1093/jac/dkh086;
RA   Wootton M., Avison M.B., Bennett P.M., Howe R.A., MacGowan A.P.,
RA   Walsh T.R.;
RT   "Genetic analysis of 17 genes in Staphylococcus aureus with reduced
RT   susceptibility to vancomycin (VISA) and heteroVISA.";
RL   J. Antimicrob. Chemother. 53:406-407(2004).
CC   -!- FUNCTION: Adapter protein required for efficient degradation of Spx by
CC       ClpXP under non-stress conditions. Interaction with Spx stabilizes Spx
CC       and exposes the C-terminus of Spx for recognition and proteolysis by
CC       ClpXP. {ECO:0000255|HAMAP-Rule:MF_02245}.
CC   -!- SUBUNIT: Interacts with Spx. {ECO:0000255|HAMAP-Rule:MF_02245}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_02245}.
CC   -!- SIMILARITY: Belongs to the SpxH family. {ECO:0000255|HAMAP-
CC       Rule:MF_02245}.
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DR   EMBL; AJ564072; CAD91856.1; -; Genomic_DNA.
DR   EMBL; AJ564073; CAD91857.1; -; Genomic_DNA.
DR   EMBL; AJ564074; CAD91858.1; -; Genomic_DNA.
DR   EMBL; AJ564075; CAD91859.1; -; Genomic_DNA.
DR   EMBL; AJ564076; CAD91860.1; -; Genomic_DNA.
DR   EMBL; AJ564077; CAD91861.1; -; Genomic_DNA.
DR   EMBL; AJ564078; CAD91862.1; -; Genomic_DNA.
DR   EMBL; AJ564079; CAD91863.1; -; Genomic_DNA.
DR   EMBL; AJ564080; CAD91864.1; -; Genomic_DNA.
DR   EMBL; AJ564081; CAD91865.1; -; Genomic_DNA.
DR   EMBL; AJ564082; CAD91866.1; -; Genomic_DNA.
DR   EMBL; AJ564083; CAD91867.1; -; Genomic_DNA.
DR   EMBL; AJ564084; CAD91868.1; -; Genomic_DNA.
DR   EMBL; AJ564085; CAD91869.1; -; Genomic_DNA.
DR   EMBL; AJ564086; CAD91870.1; -; Genomic_DNA.
DR   EMBL; AJ564087; CAD91871.1; -; Genomic_DNA.
DR   EMBL; AJ564088; CAD91872.1; -; Genomic_DNA.
DR   EMBL; AJ564089; CAD91873.1; -; Genomic_DNA.
DR   EMBL; AJ564090; CAD91874.1; -; Genomic_DNA.
DR   EMBL; AJ564091; CAD91875.1; -; Genomic_DNA.
DR   EMBL; AJ564092; CAD91876.1; -; Genomic_DNA.
DR   EMBL; AJ564093; CAD91877.1; -; Genomic_DNA.
DR   EMBL; AJ564094; CAD91878.1; -; Genomic_DNA.
DR   EMBL; AJ564095; CAD91879.1; -; Genomic_DNA.
DR   EMBL; AJ564096; CAD91880.1; -; Genomic_DNA.
DR   EMBL; AJ564097; CAD91881.1; -; Genomic_DNA.
DR   EMBL; AJ564098; CAD91882.1; -; Genomic_DNA.
DR   EMBL; AJ564099; CAD91883.1; -; Genomic_DNA.
DR   EMBL; AJ564100; CAD91884.1; -; Genomic_DNA.
DR   EMBL; AJ564101; CAD91885.1; -; Genomic_DNA.
DR   AlphaFoldDB; P0C5Z9; -.
DR   SMR; P0C5Z9; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   HAMAP; MF_02245; Adapter_SpxH; 1.
DR   InterPro; IPR046404; Adapter_SpxH.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   SUPFAM; SSF52833; SSF52833; 1.
PE   3: Inferred from homology;
KW   Cytoplasm.
FT   CHAIN           <1..261
FT                   /note="ClpXP adapter protein SpxH"
FT                   /id="PRO_0000278696"
FT   NON_TER         1
SQ   SEQUENCE   261 AA;  30593 MW;  CE58B6DE0F263166 CRC64;
     MENKSREDIN LSPVSKIEIY SFFDPFSSDC FKLSAILSKL RIEYNQYIRI RHILNPSLKV
     LTKCQAQSTS NFDNIALAYK AAELQGRVRA ERFIHLMQNE IIPKRDIITE SMICDCIQNA
     GIDLEVFKDD LQKSKLTESL KIDLHIAREM EIEQAPSLVF FSEDVHEEGL KVEGLYPYHI
     YTYIINELMG KPIEKNLPPK LETYIQQQQL VTMEELLTIY EWPEKLLNKE LKKLAIQQKI
     EKLKYPDGDF WKSKMPKIKS K