ID   SPXH_STAES              Reviewed;         265 AA.
AC   Q8CT67;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 2.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=ClpXP adapter protein SpxH {ECO:0000255|HAMAP-Rule:MF_02245};
GN   Name=spxH {ECO:0000255|HAMAP-Rule:MF_02245}; OrderedLocusNames=SE_0691;
OS   Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 12228 / FDA PCI 1200;
RX   PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA   Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA   Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA   Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT   "Genome-based analysis of virulence genes in a non-biofilm-forming
RT   Staphylococcus epidermidis strain (ATCC 12228).";
RL   Mol. Microbiol. 49:1577-1593(2003).
CC   -!- FUNCTION: Adapter protein required for efficient degradation of Spx by
CC       ClpXP under non-stress conditions. Interaction with Spx stabilizes Spx
CC       and exposes the C-terminus of Spx for recognition and proteolysis by
CC       ClpXP. {ECO:0000255|HAMAP-Rule:MF_02245}.
CC   -!- SUBUNIT: Interacts with Spx. {ECO:0000255|HAMAP-Rule:MF_02245}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_02245}.
CC   -!- SIMILARITY: Belongs to the SpxH family. {ECO:0000255|HAMAP-
CC       Rule:MF_02245}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAO04288.1; Type=Erroneous initiation;
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DR   EMBL; AE015929; AAO04288.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_764246.1; NC_004461.1.
DR   RefSeq; WP_001829256.1; NZ_WBME01000019.1.
DR   AlphaFoldDB; Q8CT67; -.
DR   SMR; Q8CT67; -.
DR   STRING; 176280.SE_0691; -.
DR   EnsemblBacteria; AAO04288; AAO04288; SE_0691.
DR   GeneID; 50019169; -.
DR   KEGG; sep:SE_0691; -.
DR   PATRIC; fig|176280.10.peg.665; -.
DR   eggNOG; COG2761; Bacteria.
DR   HOGENOM; CLU_069785_0_0_9; -.
DR   Proteomes; UP000001411; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   HAMAP; MF_02245; Adapter_SpxH; 1.
DR   InterPro; IPR046404; Adapter_SpxH.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   SUPFAM; SSF52833; SSF52833; 1.
PE   3: Inferred from homology;
KW   Cytoplasm.
FT   CHAIN           1..265
FT                   /note="ClpXP adapter protein SpxH"
FT                   /id="PRO_0000278699"
SQ   SEQUENCE   265 AA;  31250 MW;  4D014598D1437CEA CRC64;
     MAEELRIMEN KSREDTNLSP VSKIEIYSFF DPFSKDCFKL SAILSKLRIE YNKYIKVRHI
     LNPSLKVLTK CQAQSTSDFD NIALAYKAAE LQGRIRAERF IHLMQNEIIP KRDIITEDMI
     SDCINNAGID YQVFKEDLQK DKLTDSLKVD LHIAREMEIE QAPSLVFFSE NVHEEGLKVE
     GLYPYHIYTY IINELMGQPI EKNLPPKLEY YIQKKQLVTM EELLTIYEWP EKLLNKELKK
     LTLQQKVEKL QYPEGEFWKS KMPQC