ID   SPXH_STAS1              Reviewed;         262 AA.
AC   Q49WD1;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=ClpXP adapter protein SpxH {ECO:0000255|HAMAP-Rule:MF_02245};
GN   Name=spxH {ECO:0000255|HAMAP-Rule:MF_02245}; OrderedLocusNames=SSP1783;
OS   Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM
OS   20229 / NCIMB 8711 / NCTC 7292 / S-41).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=342451;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41;
RX   PubMed=16135568; DOI=10.1073/pnas.0502950102;
RA   Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M.,
RA   Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.;
RT   "Whole genome sequence of Staphylococcus saprophyticus reveals the
RT   pathogenesis of uncomplicated urinary tract infection.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005).
CC   -!- FUNCTION: Adapter protein required for efficient degradation of Spx by
CC       ClpXP under non-stress conditions. Interaction with Spx stabilizes Spx
CC       and exposes the C-terminus of Spx for recognition and proteolysis by
CC       ClpXP. {ECO:0000255|HAMAP-Rule:MF_02245}.
CC   -!- SUBUNIT: Interacts with Spx. {ECO:0000255|HAMAP-Rule:MF_02245}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_02245}.
CC   -!- SIMILARITY: Belongs to the SpxH family. {ECO:0000255|HAMAP-
CC       Rule:MF_02245}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AP008934; BAE18928.1; -; Genomic_DNA.
DR   RefSeq; WP_011303484.1; NZ_MTGA01000039.1.
DR   AlphaFoldDB; Q49WD1; -.
DR   SMR; Q49WD1; -.
DR   STRING; 342451.SSP1783; -.
DR   EnsemblBacteria; BAE18928; BAE18928; SSP1783.
DR   GeneID; 66867957; -.
DR   KEGG; ssp:SSP1783; -.
DR   eggNOG; COG2761; Bacteria.
DR   HOGENOM; CLU_069785_0_0_9; -.
DR   OMA; YRMGGLL; -.
DR   OrthoDB; 996965at2; -.
DR   Proteomes; UP000006371; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   HAMAP; MF_02245; Adapter_SpxH; 1.
DR   InterPro; IPR046404; Adapter_SpxH.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   SUPFAM; SSF52833; SSF52833; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..262
FT                   /note="ClpXP adapter protein SpxH"
FT                   /id="PRO_0000278701"
SQ   SEQUENCE   262 AA;  30473 MW;  096707275EB0CD52 CRC64;
     MTEELRLIQP NSREDANLSP VSKIEIYSFF DPFSKECFKL SAILSKLRIE YKQYISIRHI
     LNPSLRVLTK CQAQSTSDLD NIALAYKAAE LQGRIRAERF IHLVQNEIIP KRDIITESMV
     NSCISNAGLD YEVFKEDLNS SCLKESLQVD LHIAREMEIE EAPSLVFFNE DVHEEGLKVE
     GLYPYHIYTY IINELIGSTI EKELPPSLED YIQQQQLVTK EELLTIYEWP EKLMNKELKK
     LALQQKIEKL KSPDGKFWKA KN