SPXM1_ARATH
ID SPXM1_ARATH Reviewed; 697 AA.
AC Q2V4F9; Q94C80; Q9CAP0; Q9LQ03;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 10-JAN-2006, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=SPX domain-containing membrane protein At1g63010;
GN OrderedLocusNames=At1g63010; ORFNames=F16M19.18, F16P17.18;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 54-697.
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q2V4F9-1; Sequence=Displayed;
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG51602.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC010795; AAG51602.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC011000; AAF75814.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE34037.1; -; Genomic_DNA.
DR EMBL; AK230262; BAF02064.1; -; mRNA.
DR EMBL; AY035094; AAK59599.1; -; mRNA.
DR PIR; C96655; C96655.
DR RefSeq; NP_001077762.1; NM_001084293.1.
DR RefSeq; NP_001077763.1; NM_001084294.2.
DR RefSeq; NP_001322578.1; NM_001334059.1.
DR RefSeq; NP_001322579.1; NM_001334060.1.
DR RefSeq; NP_564807.2; NM_104979.4.
DR RefSeq; NP_974073.2; NM_202344.2. [Q2V4F9-1]
DR AlphaFoldDB; Q2V4F9; -.
DR STRING; 3702.AT1G63010.5; -.
DR TCDB; 2.A.1.2.61; the major facilitator superfamily (mfs).
DR PaxDb; Q2V4F9; -.
DR PRIDE; Q2V4F9; -.
DR ProteomicsDB; 245248; -. [Q2V4F9-1]
DR EnsemblPlants; AT1G63010.2; AT1G63010.2; AT1G63010. [Q2V4F9-1]
DR GeneID; 842604; -.
DR Gramene; AT1G63010.2; AT1G63010.2; AT1G63010. [Q2V4F9-1]
DR KEGG; ath:AT1G63010; -.
DR Araport; AT1G63010; -.
DR eggNOG; KOG1161; Eukaryota.
DR eggNOG; KOG2325; Eukaryota.
DR HOGENOM; CLU_025236_1_0_1; -.
DR InParanoid; Q2V4F9; -.
DR OMA; SVIQYVA; -.
DR PhylomeDB; Q2V4F9; -.
DR PRO; PR:Q2V4F9; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q2V4F9; baseline and differential.
DR Genevisible; Q2V4F9; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0009705; C:plant-type vacuole membrane; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1905011; P:transmembrane phosphate ion transport from cytosol to vacuole; IBA:GO_Central.
DR CDD; cd14479; SPX-MFS_plant; 1.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004331; SPX_dom.
DR InterPro; IPR045264; SPXM_SPX_plant.
DR Pfam; PF07690; MFS_1; 1.
DR Pfam; PF03105; SPX; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS51382; SPX; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..697
FT /note="SPX domain-containing membrane protein At1g63010"
FT /id="PRO_0000300104"
FT TRANSMEM 247..267
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 278..298
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 315..335
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 337..356
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 375..395
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 411..431
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 513..533
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 544..564
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 576..596
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 604..624
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 670..690
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 2..145
FT /note="SPX"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00714"
FT REGION 439..459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 697 AA; 78051 MW; 4E044E44C8C21EC4 CRC64;
MVAFGKYLQR KQIEEWSGYY INYKLMKKKV KQYAEQIQGG SQHPRHVLKD FSRMLDTQIE
TTVLFMLEQQ GLLSGRLAKL RESHDAILEQ PDISRIFELR EAYRDVGRDL LQLLKFVELN
AIGLRKILKK FDKRFGYRFA DYYVKTRANH PYSQLQQVFK HVGVGAVVGA ISRNLHELQE
NEGSFYSIYD QPVLPAQDPV VEAINNAVDK LTFSTNFLNF LAQHALIMQD DLVTPSEDTI
DERSYHFNSL LLNLGNTFLY MVNTYIIVPT ADDYSMSLGA AATVCGVVIG SMAVAQVFSS
VYFSAWSNKS YFKPLVFSSI ALFIGNLMYA LAYDANSIAL LLLGRVCCGL GSARAVNRRY
ISDCVPLRIR MQASAGFVSA SALGMACGPA LAGLLQIKFK FYKFTFNQST LPGWVMAVAW
LFYLVWLCIS FREPLRDTED GEKNNRNETT SDRVESSRVE EGLRLPLLIT SGIKPEDEEE
CDESEESPED SHKPANSFIE AYRLLTPSVK VQLLIYFMLK YSMEILLSES SVITSYYFSW
TTSSVAIFLA CLGLTVLPIN ILVGSYISNM FEDRQILLTS EIIVFLGILF SFNLFVPYTV
PQYVISGLIM FVAAEVLEGV NLSLLSRVMS SRLSKGTYNG GLLSTEAGTL ARVVADATIT
LGGYLGRGHL LNATLLPSLV ICIGSIVATC CTYNSLY
