SPXM2_ARATH
ID SPXM2_ARATH Reviewed; 707 AA.
AC Q9T050;
DT 05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=SPX domain-containing membrane protein At4g11810;
GN OrderedLocusNames=At4g11810; ORFNames=T26M18.20;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC {ECO:0000305}.
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DR EMBL; AL078606; CAB44319.1; -; Genomic_DNA.
DR EMBL; AL161532; CAB78224.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE83051.1; -; Genomic_DNA.
DR PIR; T09340; T09340.
DR RefSeq; NP_192918.1; NM_117250.3.
DR AlphaFoldDB; Q9T050; -.
DR BioGRID; 12085; 1.
DR STRING; 3702.AT4G11810.1; -.
DR iPTMnet; Q9T050; -.
DR PaxDb; Q9T050; -.
DR PRIDE; Q9T050; -.
DR ProteomicsDB; 228319; -.
DR EnsemblPlants; AT4G11810.1; AT4G11810.1; AT4G11810.
DR GeneID; 826787; -.
DR Gramene; AT4G11810.1; AT4G11810.1; AT4G11810.
DR KEGG; ath:AT4G11810; -.
DR Araport; AT4G11810; -.
DR TAIR; locus:2137075; AT4G11810.
DR eggNOG; KOG1161; Eukaryota.
DR eggNOG; KOG2325; Eukaryota.
DR HOGENOM; CLU_025236_1_0_1; -.
DR InParanoid; Q9T050; -.
DR OMA; IQEWQRY; -.
DR OrthoDB; 345163at2759; -.
DR PhylomeDB; Q9T050; -.
DR PRO; PR:Q9T050; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q9T050; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0009705; C:plant-type vacuole membrane; IDA:TAIR.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006817; P:phosphate ion transport; IMP:TAIR.
DR GO; GO:1905011; P:transmembrane phosphate ion transport from cytosol to vacuole; IGI:TAIR.
DR CDD; cd14479; SPX-MFS_plant; 1.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004331; SPX_dom.
DR InterPro; IPR045264; SPXM_SPX_plant.
DR Pfam; PF07690; MFS_1; 1.
DR Pfam; PF03105; SPX; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS51382; SPX; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..707
FT /note="SPX domain-containing membrane protein At4g11810"
FT /id="PRO_0000398568"
FT TRANSMEM 252..272
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 283..303
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 320..340
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 342..361
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 380..400
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 416..436
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 523..543
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 557..577
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 586..606
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 614..634
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 679..699
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 2..145
FT /note="SPX"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00714"
FT REGION 481..503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 707 AA; 79419 MW; DA1F8F4BF88A7FF2 CRC64;
MVAFGKKLKE RSIEEWQEYY INYKLMKKKV KQYGPQIEVG SLDRRHVLKD FSRMLDHQIE
KIALFMLEQQ GLLSSRLQKL REWHDTLQDE PDLSQIAKLR EAYRAVGQDL LKLLFFIDMN
AIGIRKILKK FDKRFGYRFT NYYVKTRADH PYSQLQQVFR HVGLGAVVGA ISRNLHELQN
NEGSYLSIYD QPVLPLQDPV VDSIKNAVDR LTHSTNFLNF MAQHALIMQD DEDLLMLPPD
EQAEKEEGRY HFMSLLLNLA NTFLYMVNTY IIVPTADDYS MSLGAAATVC GVVIGAMAVA
QLFSSVYFSA WSNKSYFKPL IFSSIVLFFG NLLYALAYDF NSLALLLIGR LFCGFGSARA
VNRRYISDCV PLKIRMQASA GFVSASALGM ACGPALAGLL QTDFKIKNVT FNQDTLPGWV
MAVAWLLYLV WLAISFREPA REPEEIHTSQ ESTSEQIFCG EADQDGNIEK GLKKPLLLAS
EETEHDEEDD GDGSEESSDD SRKPANSFVA AYKLLTPSVK VQLLIYFMLK YAMEILLSES
SVVTTYYFGW SMSSVSIFLF CLGLTVLPVN LVVGSYISNM FEDRQILLAS EIMVCIGIVL
SFHVVIPYTV PQYVISGFIM FVSAEVLEGV NLSLLSRVMS SRLSRGTYNG GLLSTEAGTI
ARVIADATIT LAGFLGQSML LNVTLLPSLI ICVLSILATC YTYNSLY
