SPXN1_HUMAN
ID SPXN1_HUMAN Reviewed; 72 AA.
AC Q5VSR9;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Sperm protein associated with the nucleus on the X chromosome N1;
DE AltName: Full=Nuclear-associated protein SPAN-Xn1;
DE Short=SPANX-N1;
DE AltName: Full=SPANX family member N1;
GN Name=SPANXN1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=14973187; DOI=10.1073/pnas.0308532100;
RA Kouprina N., Mullokandov M., Rogozin I.B., Collins N.K., Solomon G.,
RA Otstot J., Risinger J.I., Koonin E.V., Barrett J.C., Larionov V.;
RT "The SPANX gene family of cancer/testis-specific antigens: rapid evolution
RT and amplification in African great apes and hominids.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:3077-3082(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=16251457; DOI=10.1101/gr.4212705;
RA Kouprina N., Pavlicek A., Noskov V.N., Solomon G., Otstot J., Isaacs W.,
RA Carpten J.D., Trent J.M., Schleutker J., Barrett J.C., Jurka J.,
RA Larionov V.;
RT "Dynamic structure of the SPANX gene cluster mapped to the prostate cancer
RT susceptibility locus HPCX at Xq27.";
RL Genome Res. 15:1477-1486(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
CC -!- SIMILARITY: Belongs to the SPAN-X family. {ECO:0000305}.
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DR EMBL; AY825029; AAV97585.1; -; Genomic_DNA.
DR EMBL; DQ336121; ABC61872.1; -; mRNA.
DR EMBL; DQ336118; ABC61869.1; -; mRNA.
DR EMBL; DQ336119; ABC61870.1; -; mRNA.
DR EMBL; DQ336120; ABC61871.1; -; mRNA.
DR EMBL; AL356499; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL713923; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS35421.1; -.
DR RefSeq; NP_001009614.1; NM_001009614.2.
DR AlphaFoldDB; Q5VSR9; -.
DR STRING; 9606.ENSP00000359524; -.
DR iPTMnet; Q5VSR9; -.
DR PhosphoSitePlus; Q5VSR9; -.
DR BioMuta; SPANXN1; -.
DR DMDM; 74746835; -.
DR MassIVE; Q5VSR9; -.
DR PaxDb; Q5VSR9; -.
DR PeptideAtlas; Q5VSR9; -.
DR PRIDE; Q5VSR9; -.
DR DNASU; 494118; -.
DR Ensembl; ENST00000370493.4; ENSP00000359524.3; ENSG00000203923.5.
DR GeneID; 494118; -.
DR KEGG; hsa:494118; -.
DR MANE-Select; ENST00000370493.4; ENSP00000359524.3; NM_001009614.3; NP_001009614.1.
DR UCSC; uc004fcb.3; human.
DR CTD; 494118; -.
DR GeneCards; SPANXN1; -.
DR HGNC; HGNC:33174; SPANXN1.
DR HPA; ENSG00000203923; Tissue enriched (testis).
DR MIM; 300664; gene.
DR neXtProt; NX_Q5VSR9; -.
DR OpenTargets; ENSG00000203923; -.
DR PharmGKB; PA162404376; -.
DR VEuPathDB; HostDB:ENSG00000203923; -.
DR eggNOG; ENOG502RXMW; Eukaryota.
DR GeneTree; ENSGT00940000164738; -.
DR HOGENOM; CLU_140435_1_0_1; -.
DR OMA; AFCYRKA; -.
DR OrthoDB; 1548789at2759; -.
DR PhylomeDB; Q5VSR9; -.
DR TreeFam; TF341404; -.
DR PathwayCommons; Q5VSR9; -.
DR SignaLink; Q5VSR9; -.
DR BioGRID-ORCS; 494118; 10 hits in 600 CRISPR screens.
DR GenomeRNAi; 494118; -.
DR Pharos; Q5VSR9; Tdark.
DR PRO; PR:Q5VSR9; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q5VSR9; protein.
DR Bgee; ENSG00000203923; Expressed in right testis and 1 other tissue.
DR InterPro; IPR010007; SPAN-X_fam.
DR PANTHER; PTHR23425; PTHR23425; 1.
DR Pfam; PF07458; SPAN-X; 1.
PE 3: Inferred from homology;
KW Reference proteome.
FT CHAIN 1..72
FT /note="Sperm protein associated with the nucleus on the X
FT chromosome N1"
FT /id="PRO_0000285538"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..40
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 72 AA; 8263 MW; 9248A461D75DDA5F CRC64;
MEQPTSSING EKRKSPCESN NENDEMQETP NRDLAPEPSL KKMKTSEYST VLAFCYRKAK
KIHSNQLEND QS
