ID   SPXN2_DANRE             Reviewed;          70 AA.
AC   A0A077DF94;
DT   26-FEB-2020, integrated into UniProtKB/Swiss-Prot.
DT   29-OCT-2014, sequence version 1.
DT   03-AUG-2022, entry version 13.
DE   RecName: Full=Spexin prohormone 2 {ECO:0000305};
DE   Contains:
DE     RecName: Full=Spexin-2 {ECO:0000303|PubMed:24517231};
DE   Flags: Precursor; Fragment;
GN   Name=spx2 {ECO:0000303|PubMed:24517231};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000312|EMBL:AIL31447.1};
RN   [1] {ECO:0000312|EMBL:AIL31447.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], SYNTHESIS, AND FUNCTION.
RX   PubMed=24517231; DOI=10.1210/en.2013-2106;
RA   Kim D.K., Yun S., Son G.H., Hwang J.I., Park C.R., Kim J.I., Kim K.,
RA   Vaudry H., Seong J.Y.;
RT   "Coevolution of the spexin/galanin/kisspeptin family: Spexin activates
RT   galanin receptor type II and III.";
RL   Endocrinology 155:1864-1873(2014).
RN   [2] {ECO:0000305}
RP   DEVELOPMENTAL STAGE.
RX   PubMed=30903017; DOI=10.1038/s41598-019-41431-7;
RA   Kim E., Jeong I., Chung A.Y., Kim S., Kwon S.H., Seong J.Y., Park H.C.;
RT   "Distribution and neuronal circuit of spexin 1/2 neurons in the zebrafish
RT   CNS.";
RL   Sci. Rep. 9:5025-5025(2019).
CC   -!- FUNCTION: [Spexin-2]: Acts as a ligand for galanin receptors galr2a and
CC       galr2b. {ECO:0000269|PubMed:24517231}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9BT56}.
CC   -!- DEVELOPMENTAL STAGE: Expressed throughout embryogenesis, from the 1
CC       cell stage to 48 hours post fertilization (hpf), with the highest
CC       levels of expression at the 1 cell stage (PubMed:30903017). In larvae 7
CC       days post fertilization (dpf), strongly expressed specifically in nerve
CC       cells in the preoptic area of the anterior hypothalamus
CC       (PubMed:30903017). Not detected in the dorsal habenula (dHb)
CC       (PubMed:30903017). {ECO:0000269|PubMed:30903017}.
CC   -!- SIMILARITY: Belongs to the spexin family. {ECO:0000305}.
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DR   EMBL; KF601217; AIL31447.1; -; mRNA.
DR   AlphaFoldDB; A0A077DF94; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005184; F:neuropeptide hormone activity; IEA:InterPro.
DR   InterPro; IPR028126; Spexin.
DR   Pfam; PF15171; Spexin; 1.
PE   2: Evidence at transcript level;
KW   Hormone; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..70
FT                   /note="Spexin prohormone 2"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_5001717507"
FT   PROPEP          23..30
FT                   /evidence="ECO:0000305|PubMed:24517231"
FT                   /id="PRO_0000448933"
FT   PEPTIDE         31..44
FT                   /note="Spexin-2"
FT                   /id="PRO_0000448934"
FT   PROPEP          45..70
FT                   /evidence="ECO:0000305|PubMed:24517231"
FT                   /id="PRO_0000448935"
FT   NON_TER         70
FT                   /evidence="ECO:0000312|EMBL:AIL31447.1"
SQ   SEQUENCE   70 AA;  8211 MW;  DD3EA4B0C0F8DDB6 CRC64;
     MISRVWILWT LVLFLLVTES HCIQKSSLSK NWGPQSMLYL KGKHGRRFVP DIDDHFISNS
     GLKSWYAVFK