SPXN2_HUMAN
ID SPXN2_HUMAN Reviewed; 180 AA.
AC Q5MJ10; Q0ZNM2;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Sperm protein associated with the nucleus on the X chromosome N2;
DE AltName: Full=Nuclear-associated protein SPAN-Xn2;
DE Short=SPANX-N2;
DE AltName: Full=SPANX family member N2;
GN Name=SPANXN2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=14973187; DOI=10.1073/pnas.0308532100;
RA Kouprina N., Mullokandov M., Rogozin I.B., Collins N.K., Solomon G.,
RA Otstot J., Risinger J.I., Koonin E.V., Barrett J.C., Larionov V.;
RT "The SPANX gene family of cancer/testis-specific antigens: rapid evolution
RT and amplification in African great apes and hominids.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:3077-3082(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT ILE-8.
RX PubMed=16251457; DOI=10.1101/gr.4212705;
RA Kouprina N., Pavlicek A., Noskov V.N., Solomon G., Otstot J., Isaacs W.,
RA Carpten J.D., Trent J.M., Schleutker J., Barrett J.C., Jurka J.,
RA Larionov V.;
RT "Dynamic structure of the SPANX gene cluster mapped to the prostate cancer
RT susceptibility locus HPCX at Xq27.";
RL Genome Res. 15:1477-1486(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
CC -!- INTERACTION:
CC Q5MJ10; Q15327: ANKRD1; NbExp=3; IntAct=EBI-12023934, EBI-5653378;
CC Q5MJ10; X5D778: ANKRD11; NbExp=3; IntAct=EBI-12023934, EBI-17183751;
CC Q5MJ10; Q8N9N5-2: BANP; NbExp=3; IntAct=EBI-12023934, EBI-11524452;
CC Q5MJ10; Q8N7W2-2: BEND7; NbExp=3; IntAct=EBI-12023934, EBI-10181188;
CC Q5MJ10; Q6PI77: BHLHB9; NbExp=3; IntAct=EBI-12023934, EBI-11519926;
CC Q5MJ10; Q86UB2: BIVM; NbExp=5; IntAct=EBI-12023934, EBI-12191873;
CC Q5MJ10; Q6NZI2: CAVIN1; NbExp=3; IntAct=EBI-12023934, EBI-2559016;
CC Q5MJ10; O60729: CDC14B; NbExp=3; IntAct=EBI-12023934, EBI-970231;
CC Q5MJ10; Q53HL2: CDCA8; NbExp=3; IntAct=EBI-12023934, EBI-979174;
CC Q5MJ10; Q8N8U2: CDYL2; NbExp=3; IntAct=EBI-12023934, EBI-8467076;
CC Q5MJ10; P38432: COIL; NbExp=3; IntAct=EBI-12023934, EBI-945751;
CC Q5MJ10; Q7L190: DPPA4; NbExp=3; IntAct=EBI-12023934, EBI-710457;
CC Q5MJ10; Q9Y2J2-2: EPB41L3; NbExp=3; IntAct=EBI-12023934, EBI-11100740;
CC Q5MJ10; Q96PV7: FAM193B; NbExp=3; IntAct=EBI-12023934, EBI-741770;
CC Q5MJ10; Q9H8W3: FAM204A; NbExp=3; IntAct=EBI-12023934, EBI-8465160;
CC Q5MJ10; U3KQK0: H2BC15; NbExp=3; IntAct=EBI-12023934, EBI-12142839;
CC Q5MJ10; Q7Z7F0-4: KHDC4; NbExp=3; IntAct=EBI-12023934, EBI-9089060;
CC Q5MJ10; Q9NPI7: KRCC1; NbExp=3; IntAct=EBI-12023934, EBI-2805442;
CC Q5MJ10; Q96JM7-2: L3MBTL3; NbExp=3; IntAct=EBI-12023934, EBI-11985629;
CC Q5MJ10; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-12023934, EBI-16439278;
CC Q5MJ10; Q9H2K0: MTIF3; NbExp=3; IntAct=EBI-12023934, EBI-3923617;
CC Q5MJ10; Q9UGY1: NOL12; NbExp=3; IntAct=EBI-12023934, EBI-716098;
CC Q5MJ10; Q9BYU1: PBX4; NbExp=3; IntAct=EBI-12023934, EBI-10302990;
CC Q5MJ10; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-12023934, EBI-79165;
CC Q5MJ10; P56182: RRP1; NbExp=3; IntAct=EBI-12023934, EBI-2880285;
CC Q5MJ10; Q9UHJ3: SFMBT1; NbExp=3; IntAct=EBI-12023934, EBI-747398;
CC Q5MJ10; Q16637: SMN2; NbExp=3; IntAct=EBI-12023934, EBI-395421;
CC Q5MJ10; Q8TAD8: SNIP1; NbExp=3; IntAct=EBI-12023934, EBI-749336;
CC Q5MJ10; P62316: SNRPD2; NbExp=3; IntAct=EBI-12023934, EBI-297993;
CC Q5MJ10; Q02447: SP3; NbExp=3; IntAct=EBI-12023934, EBI-348158;
CC Q5MJ10; Q02446: SP4; NbExp=3; IntAct=EBI-12023934, EBI-10198587;
CC Q5MJ10; P37108: SRP14; NbExp=3; IntAct=EBI-12023934, EBI-353399;
CC Q5MJ10; Q96MF2: STAC3; NbExp=3; IntAct=EBI-12023934, EBI-745680;
CC Q5MJ10; Q96C24: SYTL4; NbExp=3; IntAct=EBI-12023934, EBI-747142;
CC Q5MJ10; Q9NVV9: THAP1; NbExp=3; IntAct=EBI-12023934, EBI-741515;
CC Q5MJ10; P19237: TNNI1; NbExp=3; IntAct=EBI-12023934, EBI-746692;
CC Q5MJ10; Q5SQQ9-2: VAX1; NbExp=3; IntAct=EBI-12023934, EBI-12227803;
CC Q5MJ10; Q8IY57-5: YAF2; NbExp=3; IntAct=EBI-12023934, EBI-12111538;
CC Q5MJ10; P10074: ZBTB48; NbExp=3; IntAct=EBI-12023934, EBI-744864;
CC Q5MJ10; P17023: ZNF19; NbExp=3; IntAct=EBI-12023934, EBI-12884200;
CC Q5MJ10; Q9BSG1: ZNF2; NbExp=3; IntAct=EBI-12023934, EBI-8489229;
CC Q5MJ10; Q7Z4V0: ZNF438; NbExp=3; IntAct=EBI-12023934, EBI-11962468;
CC Q5MJ10; Q8TF50: ZNF526; NbExp=3; IntAct=EBI-12023934, EBI-11035148;
CC Q5MJ10; Q8N720: ZNF655; NbExp=3; IntAct=EBI-12023934, EBI-625509;
CC Q5MJ10; Q96N20: ZNF75A; NbExp=3; IntAct=EBI-12023934, EBI-21734356;
CC Q5MJ10; P51523: ZNF84; NbExp=3; IntAct=EBI-12023934, EBI-2849074;
CC -!- SIMILARITY: Belongs to the SPAN-X family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY825030; AAV97586.1; -; Genomic_DNA.
DR EMBL; DQ336111; ABC61862.1; -; mRNA.
DR EMBL; DQ336112; ABC61863.1; -; mRNA.
DR EMBL; DQ336113; ABC61864.1; -; mRNA.
DR EMBL; DQ336114; ABC61865.1; -; mRNA.
DR EMBL; DQ336115; ABC61866.1; -; mRNA.
DR EMBL; AL080239; CAI41652.1; -; Genomic_DNA.
DR CCDS; CCDS35419.1; -.
DR RefSeq; NP_001009615.1; NM_001009615.2.
DR AlphaFoldDB; Q5MJ10; -.
DR BioGRID; 138938; 106.
DR IntAct; Q5MJ10; 46.
DR STRING; 9606.ENSP00000470584; -.
DR iPTMnet; Q5MJ10; -.
DR PhosphoSitePlus; Q5MJ10; -.
DR BioMuta; SPANXN2; -.
DR DMDM; 74743052; -.
DR MassIVE; Q5MJ10; -.
DR PaxDb; Q5MJ10; -.
DR PeptideAtlas; Q5MJ10; -.
DR PRIDE; Q5MJ10; -.
DR Antibodypedia; 74059; 7 antibodies from 3 providers.
DR DNASU; 494119; -.
DR Ensembl; ENST00000598475.1; ENSP00000470584.1; ENSG00000268988.1.
DR GeneID; 494119; -.
DR KEGG; hsa:494119; -.
DR MANE-Select; ENST00000598475.2; ENSP00000470584.1; NM_001009615.3; NP_001009615.1.
DR UCSC; uc033exw.1; human.
DR CTD; 494119; -.
DR GeneCards; SPANXN2; -.
DR HGNC; HGNC:33175; SPANXN2.
DR HPA; ENSG00000268988; Tissue enriched (testis).
DR MIM; 300665; gene.
DR neXtProt; NX_Q5MJ10; -.
DR OpenTargets; ENSG00000268988; -.
DR PharmGKB; PA162404384; -.
DR VEuPathDB; HostDB:ENSG00000268988; -.
DR eggNOG; ENOG502RXMW; Eukaryota.
DR GeneTree; ENSGT00940000163956; -.
DR HOGENOM; CLU_140435_0_0_1; -.
DR InParanoid; Q5MJ10; -.
DR OMA; YYRKHTK; -.
DR OrthoDB; 1536698at2759; -.
DR PhylomeDB; Q5MJ10; -.
DR TreeFam; TF341404; -.
DR PathwayCommons; Q5MJ10; -.
DR SignaLink; Q5MJ10; -.
DR BioGRID-ORCS; 494119; 24 hits in 606 CRISPR screens.
DR GenomeRNAi; 494119; -.
DR Pharos; Q5MJ10; Tdark.
DR PRO; PR:Q5MJ10; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q5MJ10; protein.
DR Bgee; ENSG00000268988; Expressed in testis and 6 other tissues.
DR InterPro; IPR010007; SPAN-X_fam.
DR PANTHER; PTHR23425; PTHR23425; 2.
DR Pfam; PF07458; SPAN-X; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..180
FT /note="Sperm protein associated with the nucleus on the X
FT chromosome N2"
FT /id="PRO_0000285539"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 64..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..29
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 82..180
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 8
FT /note="T -> I (in dbSNP:rs79543398)"
FT /evidence="ECO:0000269|PubMed:16251457"
FT /id="VAR_032025"
SQ SEQUENCE 180 AA; 19917 MW; 07F91E79E1C4242F CRC64;
MEQPTSSTNG EKRKSPCESN NKKNDEMQEA PNRVLAPKQS LQKTKTIEYL TIIVYYYRKH
TKINSNQLEK DQSRENSINP VQEEEDEGLD SAEGSSQEDE DLDSSEGSSQ EDEDLDSSEG
SSQEDEDLDS SEGSSQEDED LDSSEGSSQE DEDLDPPEGS SQEDEDLDSS EGSSQEGGED
