SPXN3_HUMAN
ID SPXN3_HUMAN Reviewed; 141 AA.
AC Q5MJ09; Q0ZNK4;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Sperm protein associated with the nucleus on the X chromosome N3;
DE AltName: Full=Nuclear-associated protein SPAN-Xn3;
DE Short=SPANX-N3;
DE AltName: Full=SPANX family member N3;
GN Name=SPANXN3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=14973187; DOI=10.1073/pnas.0308532100;
RA Kouprina N., Mullokandov M., Rogozin I.B., Collins N.K., Solomon G.,
RA Otstot J., Risinger J.I., Koonin E.V., Barrett J.C., Larionov V.;
RT "The SPANX gene family of cancer/testis-specific antigens: rapid evolution
RT and amplification in African great apes and hominids.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:3077-3082(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT ASN-43.
RX PubMed=16251457; DOI=10.1101/gr.4212705;
RA Kouprina N., Pavlicek A., Noskov V.N., Solomon G., Otstot J., Isaacs W.,
RA Carpten J.D., Trent J.M., Schleutker J., Barrett J.C., Jurka J.,
RA Larionov V.;
RT "Dynamic structure of the SPANX gene cluster mapped to the prostate cancer
RT susceptibility locus HPCX at Xq27.";
RL Genome Res. 15:1477-1486(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q5MJ09; Q9BTE6-2: AARSD1; NbExp=3; IntAct=EBI-12037215, EBI-9357295;
CC Q5MJ09; Q8NEY4-2: ATP6V1C2; NbExp=3; IntAct=EBI-12037215, EBI-10270867;
CC Q5MJ09; Q6NZI2: CAVIN1; NbExp=3; IntAct=EBI-12037215, EBI-2559016;
CC Q5MJ09; Q8NHQ1: CEP70; NbExp=3; IntAct=EBI-12037215, EBI-739624;
CC Q5MJ09; Q9NTX9: FAM217B; NbExp=3; IntAct=EBI-12037215, EBI-19153639;
CC Q5MJ09; Q86W67: FAM228A; NbExp=3; IntAct=EBI-12037215, EBI-12958227;
CC Q5MJ09; P61296-2: HAND2; NbExp=3; IntAct=EBI-12037215, EBI-13086076;
CC Q5MJ09; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-12037215, EBI-16439278;
CC Q5MJ09; Q9BYU1: PBX4; NbExp=3; IntAct=EBI-12037215, EBI-10302990;
CC Q5MJ09; O00560: SDCBP; NbExp=3; IntAct=EBI-12037215, EBI-727004;
CC Q5MJ09; Q02446: SP4; NbExp=3; IntAct=EBI-12037215, EBI-10198587;
CC Q5MJ09; Q96MF2: STAC3; NbExp=3; IntAct=EBI-12037215, EBI-745680;
CC Q5MJ09; Q8IY57-5: YAF2; NbExp=3; IntAct=EBI-12037215, EBI-12111538;
CC Q5MJ09; P52747: ZNF143; NbExp=3; IntAct=EBI-12037215, EBI-2849334;
CC Q5MJ09; P36508: ZNF76; NbExp=3; IntAct=EBI-12037215, EBI-7254550;
CC -!- SIMILARITY: Belongs to the SPAN-X family. {ECO:0000305}.
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DR EMBL; AY825031; AAV97587.1; -; Genomic_DNA.
DR EMBL; DQ336128; ABC61879.1; -; mRNA.
DR EMBL; DQ336129; ABC61880.1; -; mRNA.
DR EMBL; AL030997; CAI42274.1; -; Genomic_DNA.
DR EMBL; AL080239; CAI42274.1; JOINED; Genomic_DNA.
DR EMBL; AL080239; CAI41648.1; -; Genomic_DNA.
DR EMBL; AL030997; CAI41648.1; JOINED; Genomic_DNA.
DR EMBL; BC062750; AAH62750.1; -; mRNA.
DR CCDS; CCDS35418.1; -.
DR RefSeq; NP_001009609.2; NM_001009609.3.
DR AlphaFoldDB; Q5MJ09; -.
DR BioGRID; 126541; 28.
DR IntAct; Q5MJ09; 22.
DR STRING; 9606.ENSP00000359534; -.
DR iPTMnet; Q5MJ09; -.
DR PhosphoSitePlus; Q5MJ09; -.
DR BioMuta; SPANXN3; -.
DR DMDM; 74743051; -.
DR MassIVE; Q5MJ09; -.
DR PaxDb; Q5MJ09; -.
DR PeptideAtlas; Q5MJ09; -.
DR PRIDE; Q5MJ09; -.
DR ProteomicsDB; 63581; -.
DR Antibodypedia; 56629; 61 antibodies from 11 providers.
DR DNASU; 139067; -.
DR Ensembl; ENST00000370503.2; ENSP00000359534.2; ENSG00000189252.4.
DR GeneID; 139067; -.
DR KEGG; hsa:139067; -.
DR UCSC; uc004fbw.4; human.
DR CTD; 139067; -.
DR GeneCards; SPANXN3; -.
DR HGNC; HGNC:33176; SPANXN3.
DR HPA; ENSG00000189252; Tissue enriched (testis).
DR MIM; 300666; gene.
DR neXtProt; NX_Q5MJ09; -.
DR PharmGKB; PA162404385; -.
DR VEuPathDB; HostDB:ENSG00000189252; -.
DR eggNOG; ENOG502RXMW; Eukaryota.
DR HOGENOM; CLU_140435_0_0_1; -.
DR InParanoid; Q5MJ09; -.
DR OrthoDB; 1536698at2759; -.
DR PhylomeDB; Q5MJ09; -.
DR TreeFam; TF341404; -.
DR PathwayCommons; Q5MJ09; -.
DR SignaLink; Q5MJ09; -.
DR BioGRID-ORCS; 139067; 27 hits in 684 CRISPR screens.
DR GenomeRNAi; 139067; -.
DR Pharos; Q5MJ09; Tdark.
DR PRO; PR:Q5MJ09; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q5MJ09; protein.
DR Bgee; ENSG00000189252; Expressed in right testis and 26 other tissues.
DR InterPro; IPR010007; SPAN-X_fam.
DR PANTHER; PTHR23425; PTHR23425; 1.
DR Pfam; PF07458; SPAN-X; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..141
FT /note="Sperm protein associated with the nucleus on the X
FT chromosome N3"
FT /id="PRO_0000285540"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 66..141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 103..117
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..141
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 43
FT /note="K -> N (in dbSNP:rs6654212)"
FT /evidence="ECO:0000269|PubMed:16251457"
FT /id="VAR_032026"
FT VARIANT 89
FT /note="V -> I (in dbSNP:rs5953851)"
FT /id="VAR_053684"
SQ SEQUENCE 141 AA; 15595 MW; 036B1450B93000C4 CRC64;
MEQPTSSTNG EKTKSPCESN NKKNDEMQEV PNRVLAPEQS LKKTKTSEYP IIFVYYLRKG
KKINSNQLEN EQSQENSINP IQKEEDEGVD LSEGSSNEDE DLGPCEGPSK EDKDLDSSEG
SSQEDEDLGL SEGSSQDSGE D
