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SPXN4_HUMAN
ID   SPXN4_HUMAN             Reviewed;          99 AA.
AC   Q5MJ08; Q0ZNK6; Q5W0S6;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Sperm protein associated with the nucleus on the X chromosome N4;
DE   AltName: Full=Nuclear-associated protein SPAN-Xn4;
DE            Short=SPANX-N4;
DE   AltName: Full=SPANX family member N4;
GN   Name=SPANXN4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=14973187; DOI=10.1073/pnas.0308532100;
RA   Kouprina N., Mullokandov M., Rogozin I.B., Collins N.K., Solomon G.,
RA   Otstot J., Risinger J.I., Koonin E.V., Barrett J.C., Larionov V.;
RT   "The SPANX gene family of cancer/testis-specific antigens: rapid evolution
RT   and amplification in African great apes and hominids.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:3077-3082(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT ASN-48.
RX   PubMed=16251457; DOI=10.1101/gr.4212705;
RA   Kouprina N., Pavlicek A., Noskov V.N., Solomon G., Otstot J., Isaacs W.,
RA   Carpten J.D., Trent J.M., Schleutker J., Barrett J.C., Jurka J.,
RA   Larionov V.;
RT   "Dynamic structure of the SPANX gene cluster mapped to the prostate cancer
RT   susceptibility locus HPCX at Xq27.";
RL   Genome Res. 15:1477-1486(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15772651; DOI=10.1038/nature03440;
RA   Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA   Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA   Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA   Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA   Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA   Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA   Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA   Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA   Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA   Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA   Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA   Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA   Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA   Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA   Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA   Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA   Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA   Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA   Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA   Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA   Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA   Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA   Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA   Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA   Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA   Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA   Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA   Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA   Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA   McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA   Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA   Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA   Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA   Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA   Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA   Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA   Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA   Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA   Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA   d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA   Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA   Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA   Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA   Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA   Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA   Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA   Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA   Rogers J., Bentley D.R.;
RT   "The DNA sequence of the human X chromosome.";
RL   Nature 434:325-337(2005).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SIMILARITY: Belongs to the SPAN-X family. {ECO:0000305}.
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DR   EMBL; AY825032; AAV97588.1; -; Genomic_DNA.
DR   EMBL; DQ336126; ABC61877.1; -; mRNA.
DR   EMBL; DQ336127; ABC61878.1; -; mRNA.
DR   EMBL; AL137840; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC130503; AAI30504.1; -; mRNA.
DR   EMBL; BC130505; AAI30506.1; -; mRNA.
DR   CCDS; CCDS48178.1; -.
DR   RefSeq; NP_001009613.1; NM_001009613.2.
DR   AlphaFoldDB; Q5MJ08; -.
DR   BioGRID; 137551; 54.
DR   IntAct; Q5MJ08; 4.
DR   MINT; Q5MJ08; -.
DR   STRING; 9606.ENSP00000405210; -.
DR   iPTMnet; Q5MJ08; -.
DR   PhosphoSitePlus; Q5MJ08; -.
DR   BioMuta; SPANXN4; -.
DR   DMDM; 74706909; -.
DR   MassIVE; Q5MJ08; -.
DR   PaxDb; Q5MJ08; -.
DR   PeptideAtlas; Q5MJ08; -.
DR   PRIDE; Q5MJ08; -.
DR   ProteomicsDB; 63580; -.
DR   Antibodypedia; 52426; 13 antibodies from 8 providers.
DR   DNASU; 441525; -.
DR   Ensembl; ENST00000446864.1; ENSP00000405210.1; ENSG00000189326.4.
DR   GeneID; 441525; -.
DR   KEGG; hsa:441525; -.
DR   MANE-Select; ENST00000446864.2; ENSP00000405210.1; NM_001009613.4; NP_001009613.1.
DR   UCSC; uc004fbv.4; human.
DR   CTD; 441525; -.
DR   GeneCards; SPANXN4; -.
DR   HGNC; HGNC:33177; SPANXN4.
DR   HPA; ENSG00000189326; Tissue enriched (testis).
DR   MIM; 300667; gene.
DR   neXtProt; NX_Q5MJ08; -.
DR   OpenTargets; ENSG00000189326; -.
DR   PharmGKB; PA162404394; -.
DR   VEuPathDB; HostDB:ENSG00000189326; -.
DR   eggNOG; ENOG502TAR9; Eukaryota.
DR   GeneTree; ENSGT00940000165112; -.
DR   HOGENOM; CLU_140435_1_0_1; -.
DR   InParanoid; Q5MJ08; -.
DR   OrthoDB; 1530019at2759; -.
DR   PhylomeDB; Q5MJ08; -.
DR   TreeFam; TF341404; -.
DR   PathwayCommons; Q5MJ08; -.
DR   SignaLink; Q5MJ08; -.
DR   BioGRID-ORCS; 441525; 29 hits in 684 CRISPR screens.
DR   GenomeRNAi; 441525; -.
DR   Pharos; Q5MJ08; Tdark.
DR   PRO; PR:Q5MJ08; -.
DR   Proteomes; UP000005640; Chromosome X.
DR   RNAct; Q5MJ08; protein.
DR   Bgee; ENSG00000189326; Expressed in left testis and 19 other tissues.
DR   ExpressionAtlas; Q5MJ08; baseline and differential.
DR   InterPro; IPR010007; SPAN-X_fam.
DR   PANTHER; PTHR23425; PTHR23425; 1.
DR   Pfam; PF07458; SPAN-X; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..99
FT                   /note="Sperm protein associated with the nucleus on the X
FT                   chromosome N4"
FT                   /id="PRO_0000285541"
FT   REGION          1..99
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        31..45
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         48
FT                   /note="K -> N (in dbSNP:rs10482390)"
FT                   /evidence="ECO:0000269|PubMed:16251457"
FT                   /id="VAR_032027"
SQ   SEQUENCE   99 AA;  11168 MW;  A0B8381B8A11B5BB CRC64;
     MEEPTSSTNE NKMKSPCESN KRKVDKKKKN LHRASAPEQS LKETEKAKYP TLVFYCRKNK
     KRNSNQLENN QPTESSTDPI KEKGDLDISA GSPQDGGQN
 
 
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