SPXN5_HUMAN
ID SPXN5_HUMAN Reviewed; 72 AA.
AC Q5MJ07;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Sperm protein associated with the nucleus on the X chromosome N5;
DE AltName: Full=Nuclear-associated protein SPAN-Xn5;
DE Short=SPANX-N5;
DE AltName: Full=SPANX family member N5;
GN Name=SPANXN5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=14973187; DOI=10.1073/pnas.0308532100;
RA Kouprina N., Mullokandov M., Rogozin I.B., Collins N.K., Solomon G.,
RA Otstot J., Risinger J.I., Koonin E.V., Barrett J.C., Larionov V.;
RT "The SPANX gene family of cancer/testis-specific antigens: rapid evolution
RT and amplification in African great apes and hominids.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:3077-3082(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
CC -!- SIMILARITY: Belongs to the SPAN-X family. {ECO:0000305}.
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DR EMBL; AY825033; AAV97589.1; -; Genomic_DNA.
DR EMBL; AL445236; CAI41620.1; -; Genomic_DNA.
DR CCDS; CCDS35295.1; -.
DR RefSeq; NP_001009616.1; NM_001009616.3.
DR AlphaFoldDB; Q5MJ07; -.
DR BioGRID; 138948; 16.
DR IntAct; Q5MJ07; 1.
DR STRING; 9606.ENSP00000364661; -.
DR BioMuta; SPANXN5; -.
DR DMDM; 74743050; -.
DR MassIVE; Q5MJ07; -.
DR PaxDb; Q5MJ07; -.
DR PRIDE; Q5MJ07; -.
DR ProteomicsDB; 63579; -.
DR DNASU; 494197; -.
DR Ensembl; ENST00000375511.4; ENSP00000364661.3; ENSG00000204363.5.
DR GeneID; 494197; -.
DR KEGG; hsa:494197; -.
DR MANE-Select; ENST00000375511.4; ENSP00000364661.3; NM_001009616.4; NP_001009616.1.
DR UCSC; uc004drc.2; human.
DR CTD; 494197; -.
DR GeneCards; SPANXN5; -.
DR HGNC; HGNC:33178; SPANXN5.
DR HPA; ENSG00000204363; Tissue enriched (testis).
DR MIM; 300668; gene.
DR neXtProt; NX_Q5MJ07; -.
DR OpenTargets; ENSG00000204363; -.
DR PharmGKB; PA162404403; -.
DR VEuPathDB; HostDB:ENSG00000204363; -.
DR eggNOG; ENOG502RXMW; Eukaryota.
DR GeneTree; ENSGT00940000164738; -.
DR HOGENOM; CLU_140435_1_0_1; -.
DR InParanoid; Q5MJ07; -.
DR OMA; TSEYPRV; -.
DR OrthoDB; 1548789at2759; -.
DR PhylomeDB; Q5MJ07; -.
DR PathwayCommons; Q5MJ07; -.
DR BioGRID-ORCS; 494197; 10 hits in 616 CRISPR screens.
DR GenomeRNAi; 494197; -.
DR Pharos; Q5MJ07; Tdark.
DR PRO; PR:Q5MJ07; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q5MJ07; protein.
DR Bgee; ENSG00000204363; Expressed in right testis and 22 other tissues.
DR InterPro; IPR010007; SPAN-X_fam.
DR PANTHER; PTHR23425; PTHR23425; 1.
DR Pfam; PF07458; SPAN-X; 1.
PE 3: Inferred from homology;
KW Reference proteome.
FT CHAIN 1..72
FT /note="Sperm protein associated with the nucleus on the X
FT chromosome N5"
FT /id="PRO_0000285542"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 72 AA; 8277 MW; 2446A0B1767202E7 CRC64;
MEKPTSSTNG EKRKSPCDSN SKNDEMQETP NRDLVLEPSL KKMKTSEYST VLVLCYRKTK
KIHSNQLEND QS
