SPXS1_DICDI
ID SPXS1_DICDI Reviewed; 923 AA.
AC Q55B06; C7FZX7; Q55B07;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 2.
DT 25-MAY-2022, entry version 84.
DE RecName: Full=SPX and EXS domain-containing protein 1;
GN ORFNames=DDB_G0271664;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the SYG1 (TC 2.A.94) family. {ECO:0000305}.
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DR EMBL; AAFI02000006; EEU04142.1; -; Genomic_DNA.
DR RefSeq; XP_002649192.1; XM_002649146.1.
DR AlphaFoldDB; Q55B06; -.
DR SMR; Q55B06; -.
DR STRING; 44689.DDB0266489; -.
DR PaxDb; Q55B06; -.
DR EnsemblProtists; EEU04142; EEU04142; DDB_G0271664.
DR GeneID; 8617997; -.
DR KEGG; ddi:DDB_G0271664; -.
DR dictyBase; DDB_G0271664; -.
DR eggNOG; KOG1162; Eukaryota.
DR HOGENOM; CLU_316293_0_0_1; -.
DR InParanoid; Q55B06; -.
DR OMA; RILWCIC; -.
DR PhylomeDB; Q55B06; -.
DR PRO; PR:Q55B06; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR004342; EXS_C.
DR InterPro; IPR004331; SPX_dom.
DR InterPro; IPR033507; Syg1.
DR PANTHER; PTHR10783:SF4; PTHR10783:SF4; 1.
DR Pfam; PF03124; EXS; 1.
DR Pfam; PF03105; SPX; 2.
DR PROSITE; PS51380; EXS; 1.
DR PROSITE; PS51382; SPX; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..923
FT /note="SPX and EXS domain-containing protein 1"
FT /id="PRO_0000330820"
FT TRANSMEM 382..402
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 416..436
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 471..491
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 499..519
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 529..551
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 591..611
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 620..640
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 655..675
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 700..720
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 1..326
FT /note="SPX"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00714"
FT DOMAIN 585..785
FT /note="EXS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00712"
FT REGION 94..150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 185..208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 793..871
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 185..205
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 923 AA; 107067 MW; 338A384F2302CC65 CRC64;
MKFGKKLRFE CVSEWHNKYI SYGKLKKYLR YLYRSDLKQI GEAEEAHLLI NGFPSLSDSQ
EQFKQLSNSS SPIFNDGSCL ENSLDSSIGS NIIQEQSQHQ QQAQQQPPQQ AQQQPPQQAQ
QQAQQQAPQA QQQAQQQAQQ PEQQQQQDLK ESFNDITGYS IDQYEDTSNL DEKTPLISIL
DQSRPTTTTT TTTTTMNTSA GSGIFKNKKP KQIPTISIPV FSQSERERLF LSKIDEELRK
INEFFSNKEK DIILHYNKLT EHCSLILKDR NPSPKVLKNI QKAFGELYKG LTMLENYVNL
NYQGFEKILK KYDRLAPMNS SIKLDQMERI KLEKFHSSKS WRNMKEDVEL LYCKIFKLDK
ISIAKKKLAP FSESQSADYH MLKLGFAIGL SIGILAFVII LFTNKSLNQH PDWTRFVSTI
PIFRAVGIPI LAVWLWGVNV YIWDNARVNY ILIFGLDPRT SIDHRRIWKT ASFLTAIWLT
MFLLFCGTVT GNFALGDVPA QVYPLVLVIF FLSVVFFPFR FFHRKSRTLL FITLGNVIIT
PFGSTKFRAL FLGDLLTSMV KTIFDFEYTA CYFFTGDWMI NDSTRCNQVN SIALPILSGL
PLLWRFMQCI LRYRETNNKI HLGNSTKYAV GFSVVLFSAL NGNYQAYEPW SASRILWCVC
FVLSTLYMYC WDVVVDWGFM WLGKPRPLLR HQLMYKRHMW SYYYVLFSNL ILRFAWTLTI
TRIPFELPIN SELFNTITAS IELVRRFTWS IFRVENEHIC NSIQYHAFDF SEAPWKNEVP
KVESPKSLLP LSSSYPYRQD NFNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
NNNNNNTNNN INNINNINNN NNNSPSGSNS SINNSFHLGS SSYSYDNQYS IWKKSSKQYY
STSLIDSIKK KFFNNNNSNN NKK
