SPXS2_DICDI
ID SPXS2_DICDI Reviewed; 1053 AA.
AC Q86HQ3; Q555D4;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 77.
DE RecName: Full=SPX and EXS domain-containing protein 2;
GN ORFNames=DDB_G0274481;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the SYG1 (TC 2.A.94) family. {ECO:0000305}.
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DR EMBL; AAFI02000012; EAL70133.1; -; Genomic_DNA.
DR RefSeq; XP_644139.1; XM_639047.1.
DR AlphaFoldDB; Q86HQ3; -.
DR STRING; 44689.DDB0266497; -.
DR PaxDb; Q86HQ3; -.
DR EnsemblProtists; EAL70133; EAL70133; DDB_G0274481.
DR GeneID; 8619569; -.
DR KEGG; ddi:DDB_G0274481; -.
DR dictyBase; DDB_G0274481; -.
DR eggNOG; KOG1162; Eukaryota.
DR HOGENOM; CLU_290612_0_0_1; -.
DR InParanoid; Q86HQ3; -.
DR PhylomeDB; Q86HQ3; -.
DR PRO; PR:Q86HQ3; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0000822; F:inositol hexakisphosphate binding; IBA:GO_Central.
DR GO; GO:0015114; F:phosphate ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0016036; P:cellular response to phosphate starvation; IBA:GO_Central.
DR GO; GO:0006817; P:phosphate ion transport; IBA:GO_Central.
DR InterPro; IPR004342; EXS_C.
DR InterPro; IPR004331; SPX_dom.
DR Pfam; PF03124; EXS; 1.
DR Pfam; PF03105; SPX; 2.
DR PROSITE; PS51380; EXS; 1.
DR PROSITE; PS51382; SPX; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..1053
FT /note="SPX and EXS domain-containing protein 2"
FT /id="PRO_0000330821"
FT TRANSMEM 391..411
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 427..447
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 476..496
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 510..530
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 561..581
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 595..615
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 630..652
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 666..686
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 712..732
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 745..765
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 1..339
FT /note="SPX"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00714"
FT DOMAIN 596..798
FT /note="EXS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00712"
FT REGION 54..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 799..871
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1023..1053
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..111
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 112..137
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 799..843
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 854..871
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1023..1047
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1053 AA; 122393 MW; 7109AEEB8696BBE9 CRC64;
MKFRDYLKDN KVSHWRDKYI DYEYLKNLID NEYINAEILN SAIIDLPLSP EEQNNINKNN
NNNNNNNNNN NNNNNNNNNI NNNNNNNNTL KDGEQTNSNN ISIPNQMAPQ ESSGEDEDDE
NENGNGVVGD EDGGDDDEIE MDELVIDDNG EIINITATAG SRVKVKKGIN KGVKRLKKIA
KNTNNRLSRM VSRSPKNKGL GSSSEIEGDE FQLDGGGISS QIEMVASNNI TGATVFVPQE
TFQDGFIDQV NKVDIFFVDR YRKTKFKCVD LVGMIPFLSD NEQLRTIRNI DYVKQGFHDN
YHYLESLESY KNLNLDGFYK ILDKYEKINP RIAKECRKYL ENTRLTSTNS PVRELSRRIK
QIYARYFTGN DIKLANNQIR TNKQVNQFQN YIIGFLIGAS AILIAQVIFK FYYYFPDVAD
SPKNSPMAWL LFRISSLPII LGTLFALMTK LWEKAGINYV FIFELKPDIK RSSSRYLMYG
MIFVTMWLVV FNVYVDSISN KTGSPETSRY LLLIPLLFIL GSIFFLILPF KVLAHRTRFW
VLHKMSKVVQ APFVPVRFPD FFMSVQLLCL GEFLFNMQQI VCMFKFNDPL YSPSGVCFKH
KAVIFPILSV LPFYWRVMQC VRRFWETGQF FPHITSAIRS TFSIVTNILL WVANNYGNKE
WSWIKILWFI INVVGTVYKL YADFTVDWGL FLNYKTNKQW PLREKMVFKR KWVYYVAMSF
DTFFRFVWLI VFSIRQGTSY KLDHPLFLFW FSLSEIAWAA QFIFFRVESE HVQCADTYSH
FKDIPLPFSQ DYKNYMEEKK SRYDEKKPHH HHHHDNNNNE TKDGSGGTHH RRNLSNGHHP
YDDDDDDESI DSDADSKDLN LESNSEFVDD EGYNQRKNSI ISSIKKIAST QELNSMNRIS
SHPDLYSTMQ RFAGHVPDSN SSMPRMYSHP DFNHPIPRVL TSHVEVNPST LRTVPQHRLN
NIPNQRIISH ADINPQHLRV GSPRVEFNST VQQRSPHGEI QSSMIRNHSR ADLNSSMQRI
QSHPELNSSN RNQVDPNSPM NRLITRADLN KSR
