SPXS4_DICDI
ID SPXS4_DICDI Reviewed; 1081 AA.
AC Q54HI2;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 72.
DE RecName: Full=SPX and EXS domain-containing protein 4;
GN ORFNames=DDB_G0289423;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the SYG1 (TC 2.A.94) family. {ECO:0000305}.
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DR EMBL; AAFI02000140; EAL62739.1; -; Genomic_DNA.
DR RefSeq; XP_636251.1; XM_631159.1.
DR AlphaFoldDB; Q54HI2; -.
DR SMR; Q54HI2; -.
DR STRING; 44689.DDB0266496; -.
DR PaxDb; Q54HI2; -.
DR EnsemblProtists; EAL62739; EAL62739; DDB_G0289423.
DR GeneID; 8627141; -.
DR KEGG; ddi:DDB_G0289423; -.
DR dictyBase; DDB_G0289423; -.
DR eggNOG; KOG1162; Eukaryota.
DR HOGENOM; CLU_290612_0_0_1; -.
DR InParanoid; Q54HI2; -.
DR OMA; NYIALEY; -.
DR PhylomeDB; Q54HI2; -.
DR PRO; PR:Q54HI2; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0000822; F:inositol hexakisphosphate binding; IBA:GO_Central.
DR GO; GO:0015114; F:phosphate ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0016036; P:cellular response to phosphate starvation; IBA:GO_Central.
DR GO; GO:0006817; P:phosphate ion transport; IBA:GO_Central.
DR InterPro; IPR004342; EXS_C.
DR InterPro; IPR004331; SPX_dom.
DR Pfam; PF03124; EXS; 1.
DR Pfam; PF03105; SPX; 1.
DR PROSITE; PS51380; EXS; 1.
DR PROSITE; PS51382; SPX; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..1081
FT /note="SPX and EXS domain-containing protein 4"
FT /id="PRO_0000330823"
FT TRANSMEM 536..556
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 573..593
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 622..642
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 654..674
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 703..723
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 776..796
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 803..823
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 854..874
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 887..907
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 1..483
FT /note="SPX"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00714"
FT DOMAIN 738..940
FT /note="EXS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00712"
FT REGION 86..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 160..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 318..354
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 939..1031
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..118
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 207..231
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 244..263
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 319..336
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 337..354
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 953..999
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1081 AA; 126108 MW; 781543F76D13492A CRC64;
MKFRDLLNDH IISHWRDKYI DYEYLKDLID REYHNAPNSL NNSMMIDMSQ SINNTIAEQY
SVNDISSMVT KGGINDSPTT DIEVDETADS PAIPSPIISH SNINSNNNNN GGTNSVGFSH
LHRQLNRQNS NLKNSSNSIN LLKADDSNNI EKHVKSYFDQ RNNNNNINNI NNNNNNNSNN
SNNSNNNKTI KNTRNIIADD DGGNEDTTLG SPFSSPSIGS PPMSSPSPKM LKQELHSPLL
TSEKDEDEEE EGEEEEDIEM EQLELDDHDK NTTINMTANG SRGNLRKGMN QFVKTIPQNI
KQLNSQISNS FLKFGGMVKG DKSNDKNNDK SNDKNNNKNN KNNNNNNNLN DEDNFDMMTS
QIEKVLNNKD NMKLMESCTF TTKENFQTAF VDQVNKVDSF FVERYRKTKE KCVELCNMIP
FLSTNEQLRT IRNIEFVKQG FQDNYHYLES LEAFKELNIK GFKKVLEKYE KKNRIISSEC
RKYLENTRIF ENDSPVRFLS HRIKHLYARY FTGNDVKLAS NQIKTYAEDE RFQKYNLFTI
GLLIGVCIVL GIQVVFNYYY YYPHEQPPID SPLAWLLFRI SLLPILLGTM FSLMSFIWEK
SGINYVFIFE FKPDHKRSPG RYLKYGLIFN TLWLLALNLY IDSSSHQNTT RYLILIPIVF
VLITLIIGIQ PFPIMAHRTR FWVLKKIVKV VSAPWVPVRF PDFFMSVQLL SLGEFLFNIQ
SMVCVFNYSA LDPEEVKFCS QSRFFALPVL NALPYWWRVA QCFRRYYETR QFFPHITSAI
RSIFSIIALV LNYIALEYSQ HDWSIIKIAW FGINVVGSFY KFYADMSVDW GFFNNYKTNP
AWPLREKLVF KKKWIYYVAI TLDFFLRFTW LIIFSIRKGS KHRLDNPLFL FFFSLTEVVW
ATQFIFFRVE SEHVQSPDTY SSFQDIPIPF SQEYNNYMDE KKKRRKRKQK QSKSNNNNNN
NNNNNNNNNN RLHHNDSSNN VETDETITSS NNTDSSHQKQ PLTHNRHHNH NHNHQDHHDL
SINDHMNPDT GDINFDSKID YKDDEAYNLR QSSLRTSISR NASHVDLGRV SSHNDLNISR
G
