SPX_ALKCK
ID SPX_ALKCK Reviewed; 131 AA.
AC Q5WEZ7;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 25-MAY-2022, entry version 108.
DE RecName: Full=Global transcriptional regulator Spx {ECO:0000255|HAMAP-Rule:MF_01132};
GN Name=spx {ECO:0000255|HAMAP-Rule:MF_01132}; OrderedLocusNames=ABC2528;
OS Alkalihalobacillus clausii (strain KSM-K16) (Bacillus clausii).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Alkalihalobacillus.
OX NCBI_TaxID=66692;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KSM-K16;
RA Takaki Y., Kageyama Y., Shimamura S., Suzuki H., Nishi S., Hatada Y.,
RA Kawai S., Ito S., Horikoshi K.;
RT "The complete genome sequence of the alkaliphilic Bacillus clausii KSM-
RT K16.";
RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Global transcriptional regulator that plays a key role in
CC stress response and exerts either positive or negative regulation of
CC genes. Acts by interacting with the C-terminal domain of the alpha
CC subunit of the RNA polymerase (RNAP). This interaction can enhance
CC binding of RNAP to the promoter region of target genes and stimulate
CC their transcription, or block interaction of RNAP with activator.
CC {ECO:0000255|HAMAP-Rule:MF_01132}.
CC -!- SUBUNIT: Interacts with the C-terminal domain of the alpha subunit of
CC the RNAP. {ECO:0000255|HAMAP-Rule:MF_01132}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01132}.
CC -!- SIMILARITY: Belongs to the ArsC family. Spx subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01132}.
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DR EMBL; AP006627; BAD65063.1; -; Genomic_DNA.
DR RefSeq; WP_011247371.1; NC_006582.1.
DR AlphaFoldDB; Q5WEZ7; -.
DR SMR; Q5WEZ7; -.
DR STRING; 66692.ABC2528; -.
DR EnsemblBacteria; BAD65063; BAD65063; ABC2528.
DR GeneID; 61574950; -.
DR KEGG; bcl:ABC2528; -.
DR eggNOG; COG1393; Bacteria.
DR HOGENOM; CLU_116644_1_1_9; -.
DR OMA; IMIDDKR; -.
DR OrthoDB; 1606021at2; -.
DR Proteomes; UP000001168; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR HAMAP; MF_01132; Spx; 1.
DR InterPro; IPR006660; Arsenate_reductase-like.
DR InterPro; IPR023731; Spx.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR006504; Tscrpt_reg_Spx/MgsR.
DR PANTHER; PTHR30041; PTHR30041; 1.
DR Pfam; PF03960; ArsC; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
DR TIGRFAMs; TIGR01617; arsC_related; 1.
DR PROSITE; PS51353; ARSC; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Disulfide bond; Redox-active center; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..131
FT /note="Global transcriptional regulator Spx"
FT /id="PRO_0000162550"
FT DISULFID 10..13
FT /note="Redox-active"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01132"
SQ SEQUENCE 131 AA; 15248 MW; 4A8BA50999DB4D7B CRC64;
MVTLLTSPSC TSCRKAKAWL EEHDIPFEER NIFASPLSVE EVKQVVRMTE DGTDEIISTR
SKVFQELDVE LESLPLQKLF TIISDNPGLL RRPIIFDEKR LQVGYNDAEI RRFLPRKVRT
FQLQEAQRLV N