SPX_LISMF
ID SPX_LISMF Reviewed; 131 AA.
AC Q71XH4;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 105.
DE RecName: Full=Global transcriptional regulator Spx {ECO:0000255|HAMAP-Rule:MF_01132};
GN Name=spx {ECO:0000255|HAMAP-Rule:MF_01132};
GN OrderedLocusNames=LMOf2365_2224;
OS Listeria monocytogenes serotype 4b (strain F2365).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria.
OX NCBI_TaxID=265669;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F2365;
RX PubMed=15115801; DOI=10.1093/nar/gkh562;
RA Nelson K.E., Fouts D.E., Mongodin E.F., Ravel J., DeBoy R.T., Kolonay J.F.,
RA Rasko D.A., Angiuoli S.V., Gill S.R., Paulsen I.T., Peterson J.D.,
RA White O., Nelson W.C., Nierman W.C., Beanan M.J., Brinkac L.M.,
RA Daugherty S.C., Dodson R.J., Durkin A.S., Madupu R., Haft D.H.,
RA Selengut J., Van Aken S.E., Khouri H.M., Fedorova N., Forberger H.A.,
RA Tran B., Kathariou S., Wonderling L.D., Uhlich G.A., Bayles D.O.,
RA Luchansky J.B., Fraser C.M.;
RT "Whole genome comparisons of serotype 4b and 1/2a strains of the food-borne
RT pathogen Listeria monocytogenes reveal new insights into the core genome
RT components of this species.";
RL Nucleic Acids Res. 32:2386-2395(2004).
CC -!- FUNCTION: Global transcriptional regulator that plays a key role in
CC stress response and exerts either positive or negative regulation of
CC genes. Acts by interacting with the C-terminal domain of the alpha
CC subunit of the RNA polymerase (RNAP). This interaction can enhance
CC binding of RNAP to the promoter region of target genes and stimulate
CC their transcription, or block interaction of RNAP with activator.
CC {ECO:0000255|HAMAP-Rule:MF_01132}.
CC -!- SUBUNIT: Interacts with the C-terminal domain of the alpha subunit of
CC the RNAP. {ECO:0000255|HAMAP-Rule:MF_01132}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01132}.
CC -!- SIMILARITY: Belongs to the ArsC family. Spx subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01132}.
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DR EMBL; AE017262; AAT04991.1; -; Genomic_DNA.
DR RefSeq; WP_003720569.1; NC_002973.6.
DR AlphaFoldDB; Q71XH4; -.
DR SMR; Q71XH4; -.
DR GeneID; 61190111; -.
DR GeneID; 67410153; -.
DR KEGG; lmf:LMOf2365_2224; -.
DR HOGENOM; CLU_116644_1_1_9; -.
DR OMA; IMIDDKR; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR HAMAP; MF_01132; Spx; 1.
DR InterPro; IPR006660; Arsenate_reductase-like.
DR InterPro; IPR023731; Spx.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR006504; Tscrpt_reg_Spx/MgsR.
DR PANTHER; PTHR30041; PTHR30041; 1.
DR Pfam; PF03960; ArsC; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
DR TIGRFAMs; TIGR01617; arsC_related; 1.
DR PROSITE; PS51353; ARSC; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Disulfide bond; Redox-active center; Transcription;
KW Transcription regulation.
FT CHAIN 1..131
FT /note="Global transcriptional regulator Spx"
FT /id="PRO_0000162558"
FT DISULFID 10..13
FT /note="Redox-active"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01132"
SQ SEQUENCE 131 AA; 15582 MW; 67181E1BA6CD9444 CRC64;
MVTLYTSPSC TSCRKARAWL EEHDIPYKER NIFSEPLSLD EIKEILRMTE DGTDEIISTR
SKTFQKLNVD LDSLPLQQLF ELIQKNPGLL RRPIIIDEKR LQVGYNEDEI RRFLPRRVRT
YQLREAQKMV N