ID   SPY1_CHICK              Reviewed;          76 AA.
AC   Q9PTL1;
DT   21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Protein sprouty homolog 1;
DE            Short=Spry-1;
DE   Flags: Fragment;
GN   Name=SPRY1;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND INDUCTION BY FGF.
RX   PubMed=10498682; DOI=10.1242/dev.126.20.4465;
RA   Minowada G., Jarvis L.A., Chi C.L., Neubueser A., Sun X., Hacohen N.,
RA   Krasnow M.A., Martin G.R.;
RT   "Vertebrate sprouty genes are induced by FGF signaling and can cause
RT   chondrodysplasia when overexpressed.";
RL   Development 126:4465-4475(1999).
CC   -!- FUNCTION: Inhibits fibroblast growth factor (FGF)-induced retinal lens
CC       fiber differentiation (By similarity). Inhibits TGFB-induced
CC       epithelial-to-mesenchymal transition in lens epithelial cells (By
CC       similarity). {ECO:0000250|UniProtKB:Q9QXV9}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein.
CC       Note=Found in the cytoplasm in unstimulated cells but is translocated
CC       to the membrane ruffles in cells stimulated with EGF (epidermal growth
CC       factor).
CC   -!- TISSUE SPECIFICITY: Brain and interlimb region.
CC   -!- INDUCTION: By FGF signaling. {ECO:0000269|PubMed:10498682}.
CC   -!- DOMAIN: The Cys-rich domain is responsible for the localization of the
CC       protein to the membrane ruffles.
CC   -!- DISEASE: Note=Overexpression during skeletal development causes a
CC       severe chondrodysplasia in which cartilage cell differentiation is
CC       inhibited.
CC   -!- SIMILARITY: Belongs to the sprouty family. {ECO:0000305}.
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DR   EMBL; AF177875; AAD56008.1; -; mRNA.
DR   AlphaFoldDB; Q9PTL1; -.
DR   VEuPathDB; HostDB:geneid_395583; -.
DR   InParanoid; Q9PTL1; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0048513; P:animal organ development; IBA:GO_Central.
DR   GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:InterPro.
DR   GO; GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; IEA:InterPro.
DR   GO; GO:0040037; P:negative regulation of fibroblast growth factor receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0043407; P:negative regulation of MAP kinase activity; IBA:GO_Central.
DR   GO; GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:GO_Central.
DR   GO; GO:0001759; P:organ induction; IEA:InterPro.
DR   InterPro; IPR007875; Sprouty.
DR   InterPro; IPR030783; SPRY1.
DR   PANTHER; PTHR12365:SF10; PTHR12365:SF10; 1.
DR   Pfam; PF05210; Sprouty; 1.
DR   PROSITE; PS51227; SPR; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Developmental protein; Membrane; Reference proteome.
FT   CHAIN           <1..76
FT                   /note="Protein sprouty homolog 1"
FT                   /id="PRO_0000076900"
FT   DOMAIN          1..52
FT                   /note="SPR"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00572"
FT   NON_TER         1
SQ   SEQUENCE   76 AA;  8349 MW;  6B141142FC24C2F8 CRC64;
     NPCSCSQSHC CSRYLCMGAM SLFLPCLLCY PPAKGCLKLC RGCYDRVNRP GCRCKNSNTV
     YCKLESCPSR GQGKPS