SPY3_HUMAN
ID SPY3_HUMAN Reviewed; 288 AA.
AC O43610; A8K0H8;
DT 21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT 21-FEB-2001, sequence version 2.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Protein sprouty homolog 3 {ECO:0000305};
DE Short=Spry-3 {ECO:0000305};
DE AltName: Full=Sprouty RTK signaling antagonist 3 {ECO:0000312|HGNC:HGNC:11271};
DE AltName: Full=Sprouty3 {ECO:0000303|PubMed:30878395};
GN Name=SPRY3 {ECO:0000312|HGNC:HGNC:11271};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10655549; DOI=10.1093/hmg/9.3.395;
RA Ciccodicola A., D'Esposito M., Esposito T., Gianfrancesco F.,
RA Migliaccio C., Miano M.G., Matarazzo M.R., Vacca M., Franze A.,
RA Cuccurese M., Cocchia M., Curci A., Terracciano A., Torino A., Cocchia S.,
RA Mercadante G., Pannone E., Archidiacono N., Rocchi M., Schlessinger D.,
RA D'Urso M.;
RT "Differentially regulated and evolved genes in the fully sequenced Xq/Yq
RT pseudoautosomal region.";
RL Hum. Mol. Genet. 9:395-401(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Cerebellum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 93-191, FUNCTION, AND INDUCTION BY FGF
RP SIGNALING.
RX PubMed=9458049; DOI=10.1016/s0092-8674(00)80919-8;
RA Hacohen N., Kramer S., Sutherland D., Hiromi Y., Krasnow M.A.;
RT "Sprouty encodes a novel antagonist of FGF signaling that patterns apical
RT branching of the Drosophila airways.";
RL Cell 92:253-263(1998).
RN [7]
RP INTERACTION WITH TESK1.
RX PubMed=17974561; DOI=10.1074/jbc.m705457200;
RA Chandramouli S., Yu C.Y., Yusoff P., Lao D.H., Leong H.F., Mizuno K.,
RA Guy G.R.;
RT "Tesk1 interacts with Spry2 to abrogate its inhibition of ERK
RT phosphorylation downstream of receptor tyrosine kinase signaling.";
RL J. Biol. Chem. 283:1679-1691(2008).
RN [8]
RP TISSUE SPECIFICITY.
RX PubMed=26089202; DOI=10.1093/hmg/ddv231;
RA Ning Z., McLellan A.S., Ball M., Wynne F., O'Neill C., Mills W.,
RA Quinn J.P., Kleinjan D.A., Anney R.J., Carmody R.J., O'Keeffe G., Moore T.;
RT "Regulation of SPRY3 by X chromosome and PAR2-linked promoters in an autism
RT susceptibility region.";
RL Hum. Mol. Genet. 24:5126-5141(2015).
RN [9]
RP INTERACTION WITH USP11.
RX PubMed=29293652; DOI=10.1371/journal.pone.0190513;
RA Stockum A., Snijders A.P., Maertens G.N.;
RT "USP11 deubiquitinates RAE1 and plays a key role in bipolar spindle
RT formation.";
RL PLoS ONE 13:e0190513-e0190513(2018).
RN [10]
RP FUNCTION, TISSUE SPECIFICITY, AND INDUCTION BY MICRORNA-143-3P.
RX PubMed=30878395; DOI=10.1016/j.yjmcc.2019.03.005;
RA Li C., Li J., Xue K., Zhang J., Wang C., Zhang Q., Chen X., Gao C., Yu X.,
RA Sun L.;
RT "MicroRNA-143-3p promotes human cardiac fibrosis via targeting sprouty3
RT after myocardial infarction.";
RL J. Mol. Cell. Cardiol. 129:281-292(2019).
CC -!- FUNCTION: Inhibits neurite branching, arbor length and neurite
CC complexity (By similarity). Inhibits EGF-mediated p42/44 ERK signaling
CC (By similarity). Negatively regulates the MAPK cascade, resulting in a
CC reduction of extracellular matrix protein accumulation
CC (PubMed:30878395). May function as an antagonist of fibroblast growth
CC factor (FGF) pathways and may negatively modulate respiratory
CC organogenesis (PubMed:9458049). {ECO:0000250|UniProtKB:Q3UUD2,
CC ECO:0000269|PubMed:30878395, ECO:0000269|PubMed:9458049}.
CC -!- SUBUNIT: Interacts with TESK1 (PubMed:17974561). Interacts with USP11
CC (PubMed:29293652). Interacts with CAV1 (via C-terminus) (By
CC similarity). {ECO:0000250|UniProtKB:Q3UUD2,
CC ECO:0000269|PubMed:17974561, ECO:0000269|PubMed:29293652}.
CC -!- INTERACTION:
CC O43610; P29972: AQP1; NbExp=3; IntAct=EBI-12290641, EBI-745213;
CC O43610; Q9BXY8: BEX2; NbExp=3; IntAct=EBI-12290641, EBI-745073;
CC O43610; Q8NEC5: CATSPER1; NbExp=3; IntAct=EBI-12290641, EBI-744545;
CC O43610; Q9H2X0: CHRD; NbExp=3; IntAct=EBI-12290641, EBI-947551;
CC O43610; Q02930-3: CREB5; NbExp=3; IntAct=EBI-12290641, EBI-10192698;
CC O43610; Q9Y223-2: GNE; NbExp=3; IntAct=EBI-12290641, EBI-11975289;
CC O43610; Q9Y4H4: GPSM3; NbExp=3; IntAct=EBI-12290641, EBI-347538;
CC O43610; P49639: HOXA1; NbExp=3; IntAct=EBI-12290641, EBI-740785;
CC O43610; O43593: HR; NbExp=3; IntAct=EBI-12290641, EBI-2880706;
CC O43610; Q5T749: KPRP; NbExp=3; IntAct=EBI-12290641, EBI-10981970;
CC O43610; O76011: KRT34; NbExp=3; IntAct=EBI-12290641, EBI-1047093;
CC O43610; Q5T7P2: LCE1A; NbExp=3; IntAct=EBI-12290641, EBI-11962058;
CC O43610; Q5T7P3: LCE1B; NbExp=3; IntAct=EBI-12290641, EBI-10245913;
CC O43610; Q5T754: LCE1F; NbExp=3; IntAct=EBI-12290641, EBI-11958008;
CC O43610; O14633: LCE2B; NbExp=3; IntAct=EBI-12290641, EBI-11478468;
CC O43610; Q5TA76: LCE3A; NbExp=3; IntAct=EBI-12290641, EBI-9394625;
CC O43610; Q9BYE3: LCE3D; NbExp=3; IntAct=EBI-12290641, EBI-6658837;
CC O43610; Q5T5B0: LCE3E; NbExp=3; IntAct=EBI-12290641, EBI-10245456;
CC O43610; O60336: MAPKBP1; NbExp=3; IntAct=EBI-12290641, EBI-947402;
CC O43610; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-12290641, EBI-16439278;
CC O43610; Q9HC98-4: NEK6; NbExp=3; IntAct=EBI-12290641, EBI-11750983;
CC O43610; Q9Y2K5: R3HDM2; NbExp=3; IntAct=EBI-12290641, EBI-948428;
CC O43610; Q92504: SLC39A7; NbExp=3; IntAct=EBI-12290641, EBI-1051105;
CC O43610; P62760: VSNL1; NbExp=3; IntAct=EBI-12290641, EBI-740943;
CC O43610; Q8IUH5: ZDHHC17; NbExp=3; IntAct=EBI-12290641, EBI-524753;
CC O43610; Q96SQ5: ZNF587; NbExp=3; IntAct=EBI-12290641, EBI-6427977;
CC O43610; Q8N720: ZNF655; NbExp=3; IntAct=EBI-12290641, EBI-625509;
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- TISSUE SPECIFICITY: Widely expressed; particularly in the fetal
CC tissues. Expressed in the brain with expression the highest in Purkinje
CC cells in the cerebellum (at protein level) (PubMed:26089202). Expressed
CC in the myocardium of the heart (PubMed:30878395).
CC {ECO:0000269|PubMed:26089202, ECO:0000269|PubMed:30878395}.
CC -!- INDUCTION: By FGF signaling (PubMed:9458049). Repressed by microRNA-
CC 143-3P, which results in activation of MAPK signaling and promotion of
CC excess accumulation of extracellular matrix. May thereby play a role in
CC myocardial fibrosis (PubMed:30878395). {ECO:0000269|PubMed:30878395,
CC ECO:0000269|PubMed:9458049}.
CC -!- MISCELLANEOUS: The gene coding for this protein is located in the
CC pseudoautosomal region 2 (PAR2) of X and Y chromosomes.
CC -!- SIMILARITY: Belongs to the sprouty family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC39567.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AJ271735; CAB96768.1; -; Genomic_DNA.
DR EMBL; AK289543; BAF82232.1; -; mRNA.
DR EMBL; CH471247; EAW55876.1; -; Genomic_DNA.
DR EMBL; BC069609; AAH69609.1; -; mRNA.
DR EMBL; BC074972; AAH74972.1; -; mRNA.
DR EMBL; BC074973; AAH74973.1; -; mRNA.
DR EMBL; AF041038; AAC39567.1; ALT_FRAME; mRNA.
DR CCDS; CCDS14769.4; -.
DR RefSeq; NP_001291919.1; NM_001304990.1.
DR RefSeq; NP_005831.1; NM_005840.2.
DR AlphaFoldDB; O43610; -.
DR BioGRID; 115545; 29.
DR IntAct; O43610; 27.
DR STRING; 9606.ENSP00000302978; -.
DR iPTMnet; O43610; -.
DR PhosphoSitePlus; O43610; -.
DR BioMuta; SPRY3; -.
DR jPOST; O43610; -.
DR MassIVE; O43610; -.
DR MaxQB; O43610; -.
DR PaxDb; O43610; -.
DR PeptideAtlas; O43610; -.
DR PRIDE; O43610; -.
DR ProteomicsDB; 49079; -.
DR Antibodypedia; 31439; 105 antibodies from 21 providers.
DR DNASU; 10251; -.
DR Ensembl; ENST00000302805.7; ENSP00000302978.2; ENSG00000168939.12.
DR Ensembl; ENST00000675360.1; ENSP00000502489.1; ENSG00000168939.12.
DR GeneID; 10251; -.
DR KEGG; hsa:10251; -.
DR UCSC; uc004fnq.2; human.
DR CTD; 10251; -.
DR DisGeNET; 10251; -.
DR GeneCards; SPRY3; -.
DR HGNC; HGNC:11271; SPRY3.
DR HPA; ENSG00000168939; Tissue enhanced (brain).
DR MIM; 300531; gene.
DR neXtProt; NX_O43610; -.
DR OpenTargets; ENSG00000168939; -.
DR PharmGKB; PA36100; -.
DR VEuPathDB; HostDB:ENSG00000168939; -.
DR eggNOG; ENOG502R5TY; Eukaryota.
DR GeneTree; ENSGT00950000183055; -.
DR HOGENOM; CLU_077696_1_0_1; -.
DR InParanoid; O43610; -.
DR OMA; CQSHTNT; -.
DR OrthoDB; 1157681at2759; -.
DR PhylomeDB; O43610; -.
DR TreeFam; TF325070; -.
DR PathwayCommons; O43610; -.
DR SignaLink; O43610; -.
DR BioGRID-ORCS; 10251; 7 hits in 562 CRISPR screens.
DR ChiTaRS; SPRY3; human.
DR GeneWiki; SPRY3; -.
DR GenomeRNAi; 10251; -.
DR Pharos; O43610; Tbio.
DR PRO; PR:O43610; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; O43610; protein.
DR Bgee; ENSG00000168939; Expressed in cortical plate and 97 other tissues.
DR Genevisible; O43610; HS.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IBA:GO_Central.
DR GO; GO:0061564; P:axon development; IEA:InterPro.
DR GO; GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.
DR GO; GO:0040037; P:negative regulation of fibroblast growth factor receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0043407; P:negative regulation of MAP kinase activity; IBA:GO_Central.
DR GO; GO:0043409; P:negative regulation of MAPK cascade; IMP:UniProtKB.
DR GO; GO:0150013; P:negative regulation of neuron projection arborization; ISS:UniProtKB.
DR GO; GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:GO_Central.
DR InterPro; IPR007875; Sprouty.
DR InterPro; IPR030786; SPRY3.
DR PANTHER; PTHR12365:SF9; PTHR12365:SF9; 1.
DR Pfam; PF05210; Sprouty; 1.
DR PROSITE; PS51227; SPR; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Neurogenesis; Reference proteome.
FT CHAIN 1..288
FT /note="Protein sprouty homolog 3"
FT /id="PRO_0000076904"
FT DOMAIN 154..260
FT /note="SPR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00572"
FT VARIANT 161
FT /note="A -> T (in dbSNP:rs35474915)"
FT /id="VAR_034519"
FT CONFLICT 93
FT /note="T -> P (in Ref. 6; AAC39567)"
FT /evidence="ECO:0000305|PubMed:9458049"
SQ SEQUENCE 288 AA; 31222 MW; 62C59F5E897D99B8 CRC64;
MDAAVTDDFQ QILPIEQLRS THASNDYVER PPAPCKQALS SPSLIVQTHK SDWSLATMPT
SLPRSLSQCH QLQPLPQHLS QSSIASSMSH STTASDQRLL ASITPSPSGQ SIIRTQPGAG
VHPKADGALK GEAEQSAGHP SEHLFICEEC GRCKCVPCTA ARPLPSCWLC NQRCLCSAES
LLDYGTCLCC VKGLFYHCST DDEDNCADEP CSCGPSSCFV RWAAMSLISL FLPCLCCYLP
TRGCLHLCQQ GYDSLRRPGC RCKRHTNTVC RKISSGSAPF PKAQEKSV
