ID   SPYY_PHYBI              Reviewed;          36 AA.
AC   P80952;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Skin peptide tyrosine-tyrosine;
DE            Short=SPYY;
DE            Short=Skin-PYY;
OS   Phyllomedusa bicolor (Two-colored leaf frog) (Rana bicolor).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Phyllomedusinae;
OC   Phyllomedusa.
OX   NCBI_TaxID=8393;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Skin secretion;
RX   PubMed=7937944; DOI=10.1073/pnas.91.22.10295;
RA   Mor A., Chartrel N., Vaudry H., Nicolas P.;
RT   "Skin peptide tyrosine-tyrosine, a member of the pancreatic polypeptide
RT   family: isolation, structure, synthesis, and endocrine activity.";
RL   Proc. Natl. Acad. Sci. U.S.A. 91:10295-10299(1994).
RN   [2]
RP   CHARACTERIZATION.
RX   PubMed=8601432; DOI=10.1016/0014-5793(96)00050-6;
RA   Vouldoukis I., Shai Y., Nicolas P., Mor A.;
RT   "Broad spectrum antibiotic activity of the skin-PYY.";
RL   FEBS Lett. 380:237-240(1996).
CC   -!- FUNCTION: Shows a broad spectrum of antibacterial activity against
CC       Gram-positive and Gram-negative bacteria, yeast and fungi.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Skin.
CC   -!- SIMILARITY: Belongs to the NPY family. {ECO:0000305}.
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DR   AlphaFoldDB; P80952; -.
DR   SMR; P80952; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR   CDD; cd00126; PAH; 1.
DR   InterPro; IPR001955; Pancreatic_hormone-like.
DR   InterPro; IPR020392; Pancreatic_hormone-like_CS.
DR   PANTHER; PTHR10533; PTHR10533; 1.
DR   Pfam; PF00159; Hormone_3; 1.
DR   PRINTS; PR00278; PANCHORMONE.
DR   SMART; SM00309; PAH; 1.
DR   PROSITE; PS00265; PANCREATIC_HORMONE_1; 1.
DR   PROSITE; PS50276; PANCREATIC_HORMONE_2; 1.
PE   1: Evidence at protein level;
KW   Amidation; Antibiotic; Antimicrobial; Direct protein sequencing; Fungicide;
KW   Hormone; Secreted.
FT   PEPTIDE         1..36
FT                   /note="Skin peptide tyrosine-tyrosine"
FT                   /id="PRO_0000044826"
FT   MOD_RES         36
FT                   /note="Tyrosine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   36 AA;  4265 MW;  0725D316031827AE CRC64;
     YPPKPESPGE DASPEEMNKY LTALRHYINL VTRQRY