ID   SPZ1_BOVIN              Reviewed;         371 AA.
AC   Q32L17;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Spermatogenic leucine zipper protein 1;
GN   Name=SPZ1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor that binds to the DNA sequence 5'-
CC       CANNTG-3'(E box) and the G-box motif. May play an important role in the
CC       regulation of cell proliferation and differentiation during
CC       spermatogenesis (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- PTM: Phosphorylated by MAPK1/ERK2 and MAPK3/ERK1. {ECO:0000250}.
CC   -!- MISCELLANEOUS: The helix-loop-helix and basic motifs form a SPZ1
CC       specific bHLH different from the classical one. {ECO:0000250}.
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DR   EMBL; BC109808; AAI09809.1; -; mRNA.
DR   RefSeq; NP_001035630.1; NM_001040540.2.
DR   AlphaFoldDB; Q32L17; -.
DR   SMR; Q32L17; -.
DR   STRING; 9913.ENSBTAP00000034157; -.
DR   PaxDb; Q32L17; -.
DR   PRIDE; Q32L17; -.
DR   Ensembl; ENSBTAT00000034259; ENSBTAP00000034157; ENSBTAG00000024593.
DR   GeneID; 519496; -.
DR   KEGG; bta:519496; -.
DR   CTD; 84654; -.
DR   VEuPathDB; HostDB:ENSBTAG00000024593; -.
DR   VGNC; VGNC:35263; SPZ1.
DR   eggNOG; ENOG502QS87; Eukaryota.
DR   GeneTree; ENSGT00950000182767; -.
DR   HOGENOM; CLU_062447_0_0_1; -.
DR   InParanoid; Q32L17; -.
DR   OMA; FNIHVAR; -.
DR   OrthoDB; 1269936at2759; -.
DR   TreeFam; TF337798; -.
DR   Proteomes; UP000009136; Chromosome 20.
DR   Bgee; ENSBTAG00000024593; Expressed in semen and 11 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   InterPro; IPR042961; Spz1.
DR   PANTHER; PTHR47889; PTHR47889; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; DNA-binding; Nucleus; Phosphoprotein;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..371
FT                   /note="Spermatogenic leucine zipper protein 1"
FT                   /id="PRO_0000280506"
FT   REGION          110..120
FT                   /note="Helix-loop-helix motif"
FT                   /evidence="ECO:0000255"
FT   REGION          121..188
FT                   /note="Basic motif"
FT                   /evidence="ECO:0000255"
FT   REGION          223..246
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          245..266
FT                   /note="Leucine-zipper"
FT   COILED          96..148
FT                   /evidence="ECO:0000255"
FT   COILED          177..289
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        223..242
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         98
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6AXY9"
FT   MOD_RES         202
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6AXY9"
SQ   SEQUENCE   371 AA;  42777 MW;  7E26B3988DBA3264 CRC64;
     MEVPTLSKTR KPPDLNEESL DLGIMIALFE IGSIPPVSCS SLPSLKSSDH EATEQRIAKK
     FESLLKEIKD IVKHVTSYEQ KVTETKEPFK ETNMFEVSEL REKIIELDEI NKELVKKLLA
     SLDLGKKENA KKQEMRLDNQ NSEDTVQDCS GDLVNCSKGQ KALPETQLSK EKAKHGFPHI
     QEENIRLRNN MERLLQEAEH WSVEHTELSK LIKSYQKSQN DIKTLKNNGT HSPTQTNNES
     AKQELEEQVK RLKEDTYSLH LIATLLENEC QILEQRVELL DELHHQKEEP LQGEPMQINH
     EQSDKEQKLP EAEKVKIHEK NMPEVEGTFH KRDQFFTSLD ICHNKKAHNN QFNTRIAKRA
     LVVKRPASSL S