ID   SPZ2A_ORYSJ             Reviewed;         424 AA.
AC   Q53KS8; A0A0P0Y0J6;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Serpin-Z2A;
DE   AltName: Full=OrysaZ2a;
GN   OrderedLocusNames=Os11g0239000, LOC_Os11g13530;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16188032; DOI=10.1186/1741-7007-3-20;
RG   The rice chromosomes 11 and 12 sequencing consortia;
RT   "The sequence of rice chromosomes 11 and 12, rich in disease resistance
RT   genes and recent gene duplications.";
RL   BMC Biol. 3:20-20(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [4]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=18060440; DOI=10.1007/s10142-007-0059-2;
RA   Roberts T.H., Hejgaard J.;
RT   "Serpins in plants and green algae.";
RL   Funct. Integr. Genomics 8:1-27(2008).
CC   -!- FUNCTION: Probable serine protease inhibitor. {ECO:0000250}.
CC   -!- DOMAIN: The reactive center loop (RCL) extends out from the body of the
CC       protein and directs binding to the target protease. The protease
CC       cleaves the serpin at the reactive site within the RCL, establishing a
CC       covalent linkage between the carboxyl group of the serpin reactive site
CC       and the serine hydroxyl of the protease. The resulting inactive serpin-
CC       protease complex is highly stable (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the serpin family. {ECO:0000305}.
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DR   EMBL; AC137993; AAX95891.1; -; Genomic_DNA.
DR   EMBL; AC145809; AAX92883.1; -; Genomic_DNA.
DR   EMBL; DP000010; ABA92262.1; -; Genomic_DNA.
DR   EMBL; AP014967; BAT13368.1; -; Genomic_DNA.
DR   RefSeq; XP_015616186.1; XM_015760700.1.
DR   AlphaFoldDB; Q53KS8; -.
DR   SMR; Q53KS8; -.
DR   STRING; 4530.OS11T0239000-00; -.
DR   PaxDb; Q53KS8; -.
DR   PRIDE; Q53KS8; -.
DR   EnsemblPlants; Os11t0239000-00; Os11t0239000-00; Os11g0239000.
DR   Gramene; Os11t0239000-00; Os11t0239000-00; Os11g0239000.
DR   KEGG; osa:107275426; -.
DR   eggNOG; KOG2392; Eukaryota.
DR   HOGENOM; CLU_023330_4_2_1; -.
DR   InParanoid; Q53KS8; -.
DR   OMA; FREMDNN; -.
DR   OrthoDB; 1124079at2759; -.
DR   Proteomes; UP000000763; Chromosome 11.
DR   Proteomes; UP000059680; Chromosome 11.
DR   Genevisible; Q53KS8; OS.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.39.10; -; 1.
DR   Gene3D; 3.30.497.10; -; 1.
DR   InterPro; IPR023796; Serpin_dom.
DR   InterPro; IPR000215; Serpin_fam.
DR   InterPro; IPR036186; Serpin_sf.
DR   InterPro; IPR042178; Serpin_sf_1.
DR   InterPro; IPR042185; Serpin_sf_2.
DR   PANTHER; PTHR11461; PTHR11461; 1.
DR   Pfam; PF00079; Serpin; 1.
DR   SMART; SM00093; SERPIN; 1.
DR   SUPFAM; SSF56574; SSF56574; 1.
PE   3: Inferred from homology;
KW   Protease inhibitor; Reference proteome; Serine protease inhibitor.
FT   CHAIN           1..424
FT                   /note="Serpin-Z2A"
FT                   /id="PRO_0000334554"
FT   REGION          370..394
FT                   /note="RCL"
FT   SITE            384..385
FT                   /note="Reactive bond"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   424 AA;  45593 MW;  CF0280C9CD1A02BB CRC64;
     MEDNAGDCGG MTAFALRLAK RLADVGVSSN KNLVFSPASL YAALALVAAG ARGTTLDELL
     ALLGAASLDD LEESVRRAVE VGLADESASG GPRVSDACGV WHDETLELKP AYRAAAAGTY
     KAVTRAANFQ RQPKRSRKKI NKWVSKATNK LIPEILPDGS VHVDTALVLV NAIYFKGKWS
     NPFPRSSTTT GKFHRLDGSS VDVPFMSSRE DQYIGFHDGF TVLKLPYHHR TMKNHGDGGD
     TITNSSITRA ILEHYGGENV GLSMYIFLPD ERDGLPALVD KMAASSSSSS FLRDHRPTRR
     REVGDLRVPR FKVSFYSQIN GVLQGMGVTA AFDAGEADLS GMAEGVDQRG GGLVVEEVFH
     RAVVEVNEEG TEAAASTACT IRLLSMSYPE DFVADHPFAF FVVEETSGAV LFAGHVLDPT
     SSSE