ID   SPZ5_ARATH              Reviewed;         433 AA.
AC   O04582;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 2.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=Probable non-inhibitory serpin-Z5;
DE   AltName: Full=ArathZ5;
GN   OrderedLocusNames=At1g62170; ORFNames=F19K23.10;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   TISSUE SPECIFICITY, GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=18060440; DOI=10.1007/s10142-007-0059-2;
RA   Roberts T.H., Hejgaard J.;
RT   "Serpins in plants and green algae.";
RL   Funct. Integr. Genomics 8:1-27(2008).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=1;
CC         Comment=A number of isoforms are produced. According to EST
CC         sequences.;
CC       Name=1;
CC         IsoId=O04582-1; Sequence=Displayed;
CC   -!- TISSUE SPECIFICITY: Weakly expressed during seedling development.
CC       {ECO:0000269|PubMed:18060440}.
CC   -!- DOMAIN: The reactive center loop (RCL) extends out from the body of the
CC       protein and directs binding to the target protease. The protease
CC       cleaves the serpin at the reactive site within the RCL, establishing a
CC       covalent linkage between the carboxyl group of the serpin reactive site
CC       and the serine hydroxyl of the protease. The resulting inactive serpin-
CC       protease complex is highly stable (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the serpin family. {ECO:0000305}.
CC   -!- CAUTION: According to PubMed:18060440, it is predicted to be a non-
CC       inhibitory serpin due to Val-384 and Thr-385 which differ from the
CC       conserved residues in the reactive center loop (RCL) that is involved
CC       after cleavage in covalent linking and inhibition of the target
CC       proteinase. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB60763.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AC000375; AAB60763.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002684; AEE33929.1; -; Genomic_DNA.
DR   PIR; B96648; B96648.
DR   RefSeq; NP_176408.1; NM_104898.1. [O04582-1]
DR   AlphaFoldDB; O04582; -.
DR   SMR; O04582; -.
DR   BioGRID; 27734; 1.
DR   IntAct; O04582; 1.
DR   STRING; 3702.AT1G62170.2; -.
DR   PRIDE; O04582; -.
DR   EnsemblPlants; AT1G62170.1; AT1G62170.1; AT1G62170. [O04582-1]
DR   GeneID; 842513; -.
DR   Gramene; AT1G62170.1; AT1G62170.1; AT1G62170. [O04582-1]
DR   KEGG; ath:AT1G62170; -.
DR   Araport; AT1G62170; -.
DR   eggNOG; KOG2392; Eukaryota.
DR   HOGENOM; CLU_023330_4_0_1; -.
DR   InParanoid; O04582; -.
DR   OMA; AKQMSEC; -.
DR   PhylomeDB; O04582; -.
DR   PRO; PR:O04582; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; O04582; differential.
DR   Genevisible; O04582; AT.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR   Gene3D; 2.30.39.10; -; 1.
DR   Gene3D; 3.30.497.10; -; 1.
DR   InterPro; IPR023795; Serpin_CS.
DR   InterPro; IPR023796; Serpin_dom.
DR   InterPro; IPR000215; Serpin_fam.
DR   InterPro; IPR036186; Serpin_sf.
DR   InterPro; IPR042178; Serpin_sf_1.
DR   InterPro; IPR042185; Serpin_sf_2.
DR   PANTHER; PTHR11461; PTHR11461; 1.
DR   Pfam; PF00079; Serpin; 2.
DR   SMART; SM00093; SERPIN; 1.
DR   SUPFAM; SSF56574; SSF56574; 1.
DR   PROSITE; PS00284; SERPIN; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Reference proteome.
FT   CHAIN           1..433
FT                   /note="Probable non-inhibitory serpin-Z5"
FT                   /id="PRO_0000334550"
FT   REGION          1..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          380..404
FT                   /note="RCL"
FT   SITE            394..395
FT                   /note="Reactive bond"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   433 AA;  48174 MW;  66BEE2E2389EF0B1 CRC64;
     MEPKEKKQKL DTSEVASPSL SKTHLKKKKT KKQKIRKSQE ITSPSLSKNT DLVIASPSLS
     NIDVGEAMKK QNDVAIFLTG IVISSVAKNS NFVFSPASIN AALTMVAASS GGEQGEELRS
     FILSFLKSSS TDELNAIFRE IASVVLVDGS KKGGPKIAVV NGMWMDQSLS VNPLSKDLFK
     NFFSAAFAQV DFRSKAEEVR TEVNAWASSH TNGLIKDLLP RGSVTSLTDR VYGSALYFKG
     TWEEKYSKSM TKCKPFYLLN GTSVSVPFMS SFEKQYIAAY DGFKVLRLPY RQGRDNTNRN
     FAMYIYLPDK KGELDDLLER MTSTPGFLDS HNPERRVKVG KFRIPKFKIE FGFEASSAFS
     DFELDVSFYQ KTLIEIDEKG TEAVTFTAFR SAYLGCALVK PIDFVADHPF LFLIREEQTG
     TVLFAGQIFD PSA