ID   SPZ8_ORYSJ              Reviewed;         422 AA.
AC   Q53P09;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 2.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Putative serpin-Z8;
DE   AltName: Full=OrysaZ8;
GN   OrderedLocusNames=Os11g0224800, LOC_Os11g11760;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16188032; DOI=10.1186/1741-7007-3-20;
RG   The rice chromosomes 11 and 12 sequencing consortia;
RT   "The sequence of rice chromosomes 11 and 12, rich in disease resistance
RT   genes and recent gene duplications.";
RL   BMC Biol. 3:20-20(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [4]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=18060440; DOI=10.1007/s10142-007-0059-2;
RA   Roberts T.H., Hejgaard J.;
RT   "Serpins in plants and green algae.";
RL   Funct. Integr. Genomics 8:1-27(2008).
CC   -!- FUNCTION: Probable serine protease inhibitor. {ECO:0000250}.
CC   -!- DOMAIN: The reactive center loop (RCL) extends out from the body of the
CC       protein and directs binding to the target protease. The protease
CC       cleaves the serpin at the reactive site within the RCL, establishing a
CC       covalent linkage between the carboxyl group of the serpin reactive site
CC       and the serine hydroxyl of the protease. The resulting inactive serpin-
CC       protease complex is highly stable (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the serpin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAX95869.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=ABA92203.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AC133005; AAX95869.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; DP000010; ABA92203.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AP014967; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; Q53P09; -.
DR   SMR; Q53P09; -.
DR   STRING; 4530.OS11T0224800-00; -.
DR   MEROPS; I04.081; -.
DR   PRIDE; Q53P09; -.
DR   eggNOG; KOG2392; Eukaryota.
DR   HOGENOM; CLU_023330_4_0_1; -.
DR   InParanoid; Q53P09; -.
DR   Proteomes; UP000000763; Chromosome 11.
DR   Proteomes; UP000059680; Chromosome 11.
DR   Genevisible; Q53P09; OS.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.39.10; -; 1.
DR   Gene3D; 3.30.497.10; -; 1.
DR   InterPro; IPR023796; Serpin_dom.
DR   InterPro; IPR000215; Serpin_fam.
DR   InterPro; IPR036186; Serpin_sf.
DR   InterPro; IPR042178; Serpin_sf_1.
DR   InterPro; IPR042185; Serpin_sf_2.
DR   PANTHER; PTHR11461; PTHR11461; 1.
DR   Pfam; PF00079; Serpin; 1.
DR   SMART; SM00093; SERPIN; 1.
DR   SUPFAM; SSF56574; SSF56574; 1.
PE   3: Inferred from homology;
KW   Protease inhibitor; Reference proteome; Serine protease inhibitor.
FT   CHAIN           1..422
FT                   /note="Putative serpin-Z8"
FT                   /id="PRO_0000334560"
FT   REGION          369..393
FT                   /note="RCL"
FT   SITE            383..384
FT                   /note="Reactive bond"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   422 AA;  45235 MW;  42A776ECF92DE33F CRC64;
     MDDGEAARRH RHRAISGGLT ALAVRLADRL GAASPGRNLA FSPLSVHAAL SLAAAGAAGG
     TLDEILAVLG AASRDDLAAF VGRTAETALA DRGPESLGPR VVFAPGVWCD AARPFKPAYR
     AAVAAEYNAE ATVVDFKNKV EEARKQINAW ARRATGKLIT DVLPPRSVGP ETAVVLGNAI
     YFKGKWDRPF NESDTERKPF YRHDGAAAAA AVADVPYMSS RSYQRVAVHD GFKVLKLRYR
     SPRLLRDKRK RGGGGDVGGE FTRYAMAIFL PDARDGLRGL VERMASRPGF LHEHMPAAWP
     VPVGEFRVPK FKVSCGGSVV GALEQLGLRL PFSPELADLS DMVEDDGSGW PLFVGDIQHK
     AVIEVNEEGT VAAAATMTRM LPSGVPPPPV DFVAEHPFAY FIVEEMSSAV VFAGHIVDPS
     ME