ID   SPZXA_ORYSJ             Reviewed;         396 AA.
AC   Q75H81; A0A0P0W0U8; Q10GX1; Q75HM8;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Serpin-ZXA;
DE   AltName: Full=OrysaZxa;
GN   OrderedLocusNames=Os03g0610650, LOC_Os03g41419;
GN   ORFNames=OSJNBa0034J04.19, OSJNBb0007E22.7;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16109971; DOI=10.1101/gr.3869505;
RG   The rice chromosome 3 sequencing consortium;
RA   Buell C.R., Yuan Q., Ouyang S., Liu J., Zhu W., Wang A., Maiti R., Haas B.,
RA   Wortman J., Pertea M., Jones K.M., Kim M., Overton L., Tsitrin T.,
RA   Fadrosh D., Bera J., Weaver B., Jin S., Johri S., Reardon M., Webb K.,
RA   Hill J., Moffat K., Tallon L., Van Aken S., Lewis M., Utterback T.,
RA   Feldblyum T., Zismann V., Iobst S., Hsiao J., de Vazeille A.R.,
RA   Salzberg S.L., White O., Fraser C.M., Yu Y., Kim H., Rambo T., Currie J.,
RA   Collura K., Kernodle-Thompson S., Wei F., Kudrna K., Ammiraju J.S.S.,
RA   Luo M., Goicoechea J.L., Wing R.A., Henry D., Oates R., Palmer M.,
RA   Pries G., Saski C., Simmons J., Soderlund C., Nelson W., de la Bastide M.,
RA   Spiegel L., Nascimento L., Huang E., Preston R., Zutavern T., Palmer L.,
RA   O'Shaughnessy A., Dike S., McCombie W.R., Minx P., Cordum H., Wilson R.,
RA   Jin W., Lee H.R., Jiang J., Jackson S.;
RT   "Sequence, annotation, and analysis of synteny between rice chromosome 3
RT   and diverged grass species.";
RL   Genome Res. 15:1284-1291(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Nipponbare;
RG   The rice full-length cDNA consortium;
RT   "Oryza sativa full length cDNA.";
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=12163647; DOI=10.1073/pnas.172183199;
RA   Koller A., Washburn M.P., Lange B.M., Andon N.L., Deciu C., Haynes P.A.,
RA   Hays L., Schieltz D., Ulaszek R., Wei J., Wolters D., Yates J.R. III;
RT   "Proteomic survey of metabolic pathways in rice.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:11969-11974(2002).
RN   [6]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=18060440; DOI=10.1007/s10142-007-0059-2;
RA   Roberts T.H., Hejgaard J.;
RT   "Serpins in plants and green algae.";
RL   Funct. Integr. Genomics 8:1-27(2008).
CC   -!- FUNCTION: Probable serine protease inhibitor. {ECO:0000250}.
CC   -!- DOMAIN: The reactive center loop (RCL) extends out from the body of the
CC       protein and directs binding to the target protease. The protease
CC       cleaves the serpin at the reactive site within the RCL, establishing a
CC       covalent linkage between the carboxyl group of the serpin reactive site
CC       and the serine hydroxyl of the protease. The resulting inactive serpin-
CC       protease complex is highly stable (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the serpin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAR87358.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=ABF97577.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AC135500; AAR87358.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AC136972; AAR00595.1; -; Genomic_DNA.
DR   EMBL; DP000009; ABF97577.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AP014959; BAS85252.1; -; Genomic_DNA.
DR   EMBL; AK243629; -; NOT_ANNOTATED_CDS; mRNA.
DR   RefSeq; XP_015632921.1; XM_015777435.1.
DR   AlphaFoldDB; Q75H81; -.
DR   SMR; Q75H81; -.
DR   STRING; 4530.OS03T0610650-01; -.
DR   MEROPS; I04.032; -.
DR   PaxDb; Q75H81; -.
DR   PRIDE; Q75H81; -.
DR   EnsemblPlants; Os03t0610650-01; Os03t0610650-01; Os03g0610650.
DR   GeneID; 9270857; -.
DR   Gramene; Os03t0610650-01; Os03t0610650-01; Os03g0610650.
DR   KEGG; osa:9270857; -.
DR   eggNOG; KOG2392; Eukaryota.
DR   HOGENOM; CLU_023330_4_0_1; -.
DR   InParanoid; Q75H81; -.
DR   OMA; HDSELPC; -.
DR   OrthoDB; 1124079at2759; -.
DR   Proteomes; UP000000763; Chromosome 3.
DR   Proteomes; UP000059680; Chromosome 3.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.39.10; -; 1.
DR   Gene3D; 3.30.497.10; -; 1.
DR   InterPro; IPR023795; Serpin_CS.
DR   InterPro; IPR023796; Serpin_dom.
DR   InterPro; IPR000215; Serpin_fam.
DR   InterPro; IPR036186; Serpin_sf.
DR   InterPro; IPR042178; Serpin_sf_1.
DR   InterPro; IPR042185; Serpin_sf_2.
DR   PANTHER; PTHR11461; PTHR11461; 1.
DR   Pfam; PF00079; Serpin; 1.
DR   SMART; SM00093; SERPIN; 1.
DR   SUPFAM; SSF56574; SSF56574; 1.
DR   PROSITE; PS00284; SERPIN; 1.
PE   1: Evidence at protein level;
KW   Protease inhibitor; Reference proteome; Serine protease inhibitor.
FT   CHAIN           1..396
FT                   /note="Serpin-ZXA"
FT                   /id="PRO_0000334565"
FT   REGION          343..367
FT                   /note="RCL"
FT   SITE            357..358
FT                   /note="Reactive bond"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   396 AA;  42140 MW;  33EA5971B713175D CRC64;
     MAADLRVSIA HQTSFALRLA AALSSPAHPA GGAGRNVAFS PLSLHVALSL VAAGAGGATR
     DQLASALGGP GSAEGLHAFA EQLVQLVLAD ASGAGGPRVA FADGVFVDAS LSLKKTFGDV
     AVGKYKAETH SVDFQTKAAE VASQVNSWVE KVTSGLIKEI LPPGSVDHTT RLVLGNALYF
     KGAWTEKFDA SKTKDGEFHL LDGKSVQAPF MSTSKKQYIL SYDNLKVLKL PYQQGGDKRQ
     FSMYILLPEA QDGLWSLAEK LNSEPEFLEK HIPTRQVTVG QFKLPKFKIS FGFEASDLLK
     SLGLHLPFSS EADLTEMVDS PEGKNLFVSS VFHKSFVEVN EEGTEAAAAT AAVITLRSAP
     IAEDFVADHP FLFLIQEDMT GVVLFVGHVV NPLLAA