ID   SQS1_PICGU              Reviewed;         749 AA.
AC   A5DEF8;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 3.
DT   25-MAY-2022, entry version 52.
DE   RecName: Full=Protein SQS1;
GN   Name=SQS1; ORFNames=PGUG_01659;
OS   Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS   / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX   NCBI_TaxID=294746;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: May be involved in splicing. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SQS1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EDK37560.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CH408156; EDK37560.2; ALT_INIT; Genomic_DNA.
DR   RefSeq; XP_001485987.1; XM_001485937.1.
DR   AlphaFoldDB; A5DEF8; -.
DR   SMR; A5DEF8; -.
DR   STRING; 4929.XP_001485987.1; -.
DR   EnsemblFungi; EDK37560; EDK37560; PGUG_01659.
DR   GeneID; 5127480; -.
DR   KEGG; pgu:PGUG_01659; -.
DR   eggNOG; KOG0154; Eukaryota.
DR   HOGENOM; CLU_021974_1_0_1; -.
DR   InParanoid; A5DEF8; -.
DR   OrthoDB; 962410at2759; -.
DR   Proteomes; UP000001997; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   CDD; cd02646; R3H_G-patch; 1.
DR   Gene3D; 3.30.1370.50; -; 1.
DR   InterPro; IPR000467; G_patch_dom.
DR   InterPro; IPR001374; R3H_dom.
DR   InterPro; IPR036867; R3H_dom_sf.
DR   InterPro; IPR034082; R3H_G-patch.
DR   Pfam; PF01585; G-patch; 1.
DR   SMART; SM00443; G_patch; 1.
DR   SUPFAM; SSF82708; SSF82708; 1.
DR   PROSITE; PS50174; G_PATCH; 1.
DR   PROSITE; PS51061; R3H; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Reference proteome.
FT   CHAIN           1..749
FT                   /note="Protein SQS1"
FT                   /id="PRO_0000324999"
FT   DOMAIN          566..629
FT                   /note="R3H"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00382"
FT   DOMAIN          702..749
FT                   /note="G-patch"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00092"
FT   REGION          1..56
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          153..265
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          289..315
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          327..353
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          441..461
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        9..44
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        162..220
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        221..239
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   749 AA;  84022 MW;  F6B32AFCF353F2A5 CRC64;
     MARGNRRNGS RRGSGTTGSS GSSRGRNNKN RGRGGSSSTS RRAANGGKRA GAGKFNAPEL
     MDLDFGAIDD VNMGTGSMRS LSKRPGRNTM MQEAFLTSKH TDRFVGEPLR KRPIEFIKAK
     EVYDPRAILE KVINKDEAND ADEATDITVS LRETTIAEQN EDNVNLDHDE NEKENEKEDV
     EDQKPVEKDE ESKDNLEGLR EAIENDEKVK SAKIDDETLE QPTIEMEDSD NEDDSQSDSE
     GFFIDTSAQP TNSPPAYVPP NDIGPNIDYD PVLTIGNVQL HTSGAGNDIT ASVRSSTHHD
     ELDSLDEFSD SESDEDAYAD YIRQLNEQDS SEELSSSDSE NESASTDANV SSTNSPQIVE
     YGFLSEDYEF DVSQISVTNV RFGIKNQFYS RCLELTGSVD DYMWVDEDDL IDFVTSKGVK
     EHRLESFLSY ITNGMINKTE NDEEEEQEVY VSSDSESDRE IYGGTAPEIE EDDDGIADLV
     AFSKSSTKFR DTIDTSAVGT TGKGSRKQLD LERFAQYELD DDIIDSLQQQ YKIRRESKKS
     KKQQHQDELM EEGLNKYNLL LKYPYTLHIK DIKDEFESFL HNPARDDLSF PPLDPHGNKT
     LTKMAKCYNC KSATQGKGIR RYIRVSKYKR TFKYLPDYGH INAILRQRPV FNRVDQKRPK
     EEYIATDGNA TKDRIRQRNK SGHNAYIPEG HIVGGMAPEI DHTNVGRQLL EKLGWVKGEG
     LGAHGNKGIS EPLVATVKKS KTGLGQTRY