ID   SQS1_VANPO              Reviewed;         767 AA.
AC   A7TQN2;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Protein SQS1;
GN   Name=SQS1; ORFNames=Kpol_1015p2;
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL
RC   Y-8283 / UCD 57-17;
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- FUNCTION: May be involved in splicing. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SQS1 family. {ECO:0000305}.
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DR   EMBL; DS480461; EDO15413.1; -; Genomic_DNA.
DR   RefSeq; XP_001643271.1; XM_001643221.1.
DR   AlphaFoldDB; A7TQN2; -.
DR   STRING; 436907.A7TQN2; -.
DR   EnsemblFungi; EDO15413; EDO15413; Kpol_1015p2.
DR   GeneID; 5543501; -.
DR   KEGG; vpo:Kpol_1015p2; -.
DR   eggNOG; KOG0154; Eukaryota.
DR   HOGENOM; CLU_021974_1_0_1; -.
DR   InParanoid; A7TQN2; -.
DR   OMA; PVFMRID; -.
DR   OrthoDB; 962410at2759; -.
DR   PhylomeDB; A7TQN2; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   CDD; cd02646; R3H_G-patch; 1.
DR   Gene3D; 3.30.1370.50; -; 1.
DR   InterPro; IPR000467; G_patch_dom.
DR   InterPro; IPR036867; R3H_dom_sf.
DR   InterPro; IPR034082; R3H_G-patch.
DR   Pfam; PF01585; G-patch; 1.
DR   SMART; SM00443; G_patch; 1.
DR   SUPFAM; SSF82708; SSF82708; 1.
DR   PROSITE; PS50174; G_PATCH; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Reference proteome.
FT   CHAIN           1..767
FT                   /note="Protein SQS1"
FT                   /id="PRO_0000325001"
FT   DOMAIN          589..652
FT                   /note="R3H"
FT   DOMAIN          716..763
FT                   /note="G-patch"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00092"
FT   REGION          1..71
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          101..127
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          147..258
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          363..387
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          466..494
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..30
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        106..120
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        147..170
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        171..236
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        243..258
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        372..387
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        466..483
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   767 AA;  88270 MW;  D61EE3E9FA399621 CRC64;
     MAKRHKHFEG RGRGGSRGRG RGRGGSRGRG RGGSRSRGAG RGGFGRSSND DNWRNSSIPF
     GDGDLGNFNF ADIDVPRGRR VYYSPDDIED YYFGKSENME SMKMGGLRPG HKREDTPRSS
     SFRARPVQFI KAKDVYDPSH DLIIKLRSKN LEQESQDEEL SQGDAESARE DFESGTEEEI
     EEEEEVLPEI EREEVEEEEV EPEEVEEEEV EPEEVDSEDA ESEEVDDKDL FFIDEEGYNE
     DTLPTVPSVS ISEDSTVKKP QKTNLEFNDI LTVGKVEINL AHDASDDGVF VSNVKKNYHP
     FSGYISQVMK NIQVSDEDDD EDDYEDEEED FQSDFSYKYE QQTTSKAISA DIEKLSISSE
     NLKNSSDISR DNSPDNNEEQ ESKDPEFGFL EEDFVINTSE VSVTNIRIGF SENSYFLKCY
     RLFGHYESKW IDQETFLDLI LNDLGLPEHR LNAYLTFIRD SLIPKEEPPE PTYSDIHFSD
     TSEEESDNDS EIGDDMREGI EDLISYATKL EKDRNFEFET KSLQTVGKGK KKKLLVQEDM
     QLDGVIASEL QDKFSTRLDN KAKKRRTKED FIDQENEKSD DLFKKYPYGL HVLNIKEEFE
     LFIRRSDKEA LVFPPLDPHG NKTITKFAKF YFMKTNKRGR GNQTHIFVQK VKATRYNEPN
     YNIIDNLTRQ RPIFMRHDVS KPRNEYQRTE RVKLPKGKFH VKEGEVVGQD APVIDRNNIG
     RILLERLGWS EGEGLGIQGN KGISEPVFAV VKKSKTGLRH ERKKRIE