ID   SQS1_YEAS7              Reviewed;         767 AA.
AC   A6ZRL6;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   03-AUG-2022, entry version 50.
DE   RecName: Full=Protein SQS1;
DE   AltName: Full=Squelch of splicing suppression protein 1;
GN   Name=SQS1; ORFNames=SCY_4577;
OS   Saccharomyces cerevisiae (strain YJM789) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=307796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YJM789;
RX   PubMed=17652520; DOI=10.1073/pnas.0701291104;
RA   Wei W., McCusker J.H., Hyman R.W., Jones T., Ning Y., Cao Z., Gu Z.,
RA   Bruno D., Miranda M., Nguyen M., Wilhelmy J., Komp C., Tamse R., Wang X.,
RA   Jia P., Luedi P., Oefner P.J., David L., Dietrich F.S., Li Y., Davis R.W.,
RA   Steinmetz L.M.;
RT   "Genome sequencing and comparative analysis of Saccharomyces cerevisiae
RT   strain YJM789.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:12825-12830(2007).
CC   -!- FUNCTION: May be involved in splicing since overexpression antagonizes
CC       the suppression of splicing defects by SPP382 mutants. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SQS1 family. {ECO:0000305}.
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DR   EMBL; AAFW02000067; EDN62598.1; -; Genomic_DNA.
DR   AlphaFoldDB; A6ZRL6; -.
DR   SMR; A6ZRL6; -.
DR   PRIDE; A6ZRL6; -.
DR   EnsemblFungi; EDN62598; EDN62598; SCY_4577.
DR   HOGENOM; CLU_021974_1_0_1; -.
DR   Proteomes; UP000007060; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   CDD; cd02646; R3H_G-patch; 1.
DR   Gene3D; 3.30.1370.50; -; 1.
DR   InterPro; IPR000467; G_patch_dom.
DR   InterPro; IPR036867; R3H_dom_sf.
DR   InterPro; IPR034082; R3H_G-patch.
DR   Pfam; PF01585; G-patch; 1.
DR   SMART; SM00443; G_patch; 1.
DR   SUPFAM; SSF82708; SSF82708; 1.
DR   PROSITE; PS50174; G_PATCH; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein.
FT   CHAIN           1..767
FT                   /note="Protein SQS1"
FT                   /id="PRO_0000325003"
FT   DOMAIN          594..656
FT                   /note="R3H"
FT   DOMAIN          720..767
FT                   /note="G-patch"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00092"
FT   REGION          1..60
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          176..200
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          466..493
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..21
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        475..490
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         105
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P53866"
FT   MOD_RES         217
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P53866"
FT   MOD_RES         255
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P53866"
FT   MOD_RES         334
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P53866"
FT   MOD_RES         343
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P53866"
FT   MOD_RES         345
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P53866"
SQ   SEQUENCE   767 AA;  86940 MW;  0DC6EEA57B2475B2 CRC64;
     MAKRHSHYQG SRRRHARGSN SKKAGRGNAK GIQGRKIKKK PTPTNSWHNS SIPLGEGDLD
     DVGADFNPGR AFISPKTIED YYFGRDAKSR SMKMGGLRPG NRYDSSTDLQ AGRAAFRKRP
     MQFVKAKEVY DPSHNMIQKL RAKNETKNSE EIVEREADVF EEPGKMTSDV EYINNEDSEN
     EDDDSQNSPS TDHSLSSNES KVEDGDLFFV DEEAQQSPDL TKIKRVCIEE IARPREVAIE
     FDPILTIGKV ELSVSEGNES KEISVDVPNK GNKTYHPFAG YISNVLHGMH TSDSDNDELD
     YEIETENNSE PLYESSASSE VDQGFNYVGQ RHNSRADNNL LPSPSPQLTE DIKCLSINGT
     KTFEGNNDNL SSPASEELEF GFKEEDFVIN TNDIVVSNIR MGGVDNSYYL RCYRLLGDYD
     FHWIDQDLLT DFVVDELGLP EDRLPAYLNF IKNSLIPKIE PAEPTYSDIP ISDSSDEGDS
     YEGDSYEDDE DMASSVVHSD IEEGLDDLIA YTLKHDTERF KTFETKSLET KGKGKKKKLL
     IDDALALDTE TLETLQSKFS KRIETKAKKR KAKEDFIDQE NRNSNDMLKK YPYGLHIQNI
     KDEFESFLSR NNDRLTFPPL DPHGNKTVMK IAKHYNMKSS KIGKANHTSV VVEKIKKTKW
     SSPNYSLIDQ LMRQRPVFMR IDIRRPREEQ AAFERTKTIR GKFHVKEGEI VGQNAPEIGN
     ENIGRRMLEK LGWKSGEGLG IQGNKGISEP IFAKIKKNRS GLRHSES