SR1IP_HUMAN
ID SR1IP_HUMAN Reviewed; 155 AA.
AC Q8N9Q2; Q32NC8;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Protein SREK1IP1;
DE AltName: Full=SFRS12-interacting protein 1;
DE AltName: Full=SREK1-interacting protein 1;
DE AltName: Full=Splicing regulatory protein of 18 kDa;
DE Short=p18SRP;
GN Name=SREK1IP1; Synonyms=P18SRP, SFRS12IP1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Uterus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=PNS;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP POSSIBLE FUNCTION, INDUCTION, AND INTERACTION WITH SFRS12.
RX PubMed=15456940; DOI=10.1385/jmn:24:2:269;
RA Heese K., Fujita M., Akatsu H., Yamamoto T., Kosaka K., Nagai Y.,
RA Sawada T.;
RT "The splicing regulatory protein p18SRP is down-regulated in Alzheimer's
RT disease brain.";
RL J. Mol. Neurosci. 24:269-276(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-146, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-52, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-146, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- FUNCTION: Possible splicing regulator involved in the control of
CC cellular survival.
CC -!- SUBUNIT: Interacts with SREK1/SFRS12. {ECO:0000269|PubMed:15456940}.
CC -!- INTERACTION:
CC Q8N9Q2; Q9NRZ7: AGPAT3; NbExp=3; IntAct=EBI-10268630, EBI-2803601;
CC Q8N9Q2; Q96LM5: C4orf45; NbExp=3; IntAct=EBI-10268630, EBI-12020542;
CC Q8N9Q2; Q9UK58: CCNL1; NbExp=3; IntAct=EBI-10268630, EBI-2836773;
CC Q8N9Q2; Q5HYN5: CT45A1; NbExp=3; IntAct=EBI-10268630, EBI-12051833;
CC Q8N9Q2; Q96D03: DDIT4L; NbExp=3; IntAct=EBI-10268630, EBI-742054;
CC Q8N9Q2; Q8IYF1: ELOA2; NbExp=3; IntAct=EBI-10268630, EBI-741705;
CC Q8N9Q2; O15520: FGF10; NbExp=3; IntAct=EBI-10268630, EBI-1035684;
CC Q8N9Q2; Q92759: GTF2H4; NbExp=3; IntAct=EBI-10268630, EBI-6380495;
CC Q8N9Q2; U3KQK0: H2BC15; NbExp=3; IntAct=EBI-10268630, EBI-12142839;
CC Q8N9Q2; A0A024RA76: hCG_1744368; NbExp=3; IntAct=EBI-10268630, EBI-10180729;
CC Q8N9Q2; P00492: HPRT1; NbExp=3; IntAct=EBI-10268630, EBI-748210;
CC Q8N9Q2; Q9BPX1: HSD17B14; NbExp=5; IntAct=EBI-10268630, EBI-742664;
CC Q8N9Q2; Q9NX58: LYAR; NbExp=3; IntAct=EBI-10268630, EBI-713507;
CC Q8N9Q2; O75367: MACROH2A1; NbExp=3; IntAct=EBI-10268630, EBI-2868511;
CC Q8N9Q2; Q6ZUT1: NKAPD1; NbExp=6; IntAct=EBI-10268630, EBI-3920396;
CC Q8N9Q2; Q5M9Q1: NKAPL; NbExp=3; IntAct=EBI-10268630, EBI-11423380;
CC Q8N9Q2; P15531: NME1; NbExp=3; IntAct=EBI-10268630, EBI-741141;
CC Q8N9Q2; Q96CD2: PPCDC; NbExp=3; IntAct=EBI-10268630, EBI-724333;
CC Q8N9Q2; O75400-2: PRPF40A; NbExp=3; IntAct=EBI-10268630, EBI-5280197;
CC Q8N9Q2; Q9NZ81: PRR13; NbExp=3; IntAct=EBI-10268630, EBI-740924;
CC Q8N9Q2; Q14498: RBM39; NbExp=3; IntAct=EBI-10268630, EBI-395290;
CC Q8N9Q2; Q2KHN1: RNF151; NbExp=3; IntAct=EBI-10268630, EBI-12002474;
CC Q8N9Q2; Q8TA86: RP9; NbExp=3; IntAct=EBI-10268630, EBI-630339;
CC Q8N9Q2; P32969: RPL9P9; NbExp=3; IntAct=EBI-10268630, EBI-358122;
CC Q8N9Q2; O00560: SDCBP; NbExp=6; IntAct=EBI-10268630, EBI-727004;
CC Q8N9Q2; Q9H190: SDCBP2; NbExp=6; IntAct=EBI-10268630, EBI-742426;
CC Q8N9Q2; Q96MF2: STAC3; NbExp=6; IntAct=EBI-10268630, EBI-745680;
CC Q8N9Q2; Q9NVV9: THAP1; NbExp=3; IntAct=EBI-10268630, EBI-741515;
CC -!- INDUCTION: Down-regulated in the brains of Alzheimer disease patients.
CC {ECO:0000269|PubMed:15456940}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI08717.1; Type=Frameshift; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK094073; BAC04279.1; -; mRNA.
DR EMBL; CH471137; EAW51368.1; -; Genomic_DNA.
DR EMBL; BC108716; AAI08717.1; ALT_FRAME; mRNA.
DR EMBL; BC127085; AAI27086.1; -; mRNA.
DR EMBL; BC127086; AAI27087.1; -; mRNA.
DR CCDS; CCDS34171.1; -.
DR RefSeq; NP_776190.1; NM_173829.3.
DR AlphaFoldDB; Q8N9Q2; -.
DR BioGRID; 130175; 58.
DR IntAct; Q8N9Q2; 47.
DR STRING; 9606.ENSP00000427401; -.
DR iPTMnet; Q8N9Q2; -.
DR PhosphoSitePlus; Q8N9Q2; -.
DR BioMuta; SREK1IP1; -.
DR DMDM; 74729743; -.
DR EPD; Q8N9Q2; -.
DR jPOST; Q8N9Q2; -.
DR MassIVE; Q8N9Q2; -.
DR MaxQB; Q8N9Q2; -.
DR PaxDb; Q8N9Q2; -.
DR PeptideAtlas; Q8N9Q2; -.
DR PRIDE; Q8N9Q2; -.
DR ProteomicsDB; 72573; -.
DR Antibodypedia; 23725; 53 antibodies from 15 providers.
DR DNASU; 285672; -.
DR Ensembl; ENST00000513458.9; ENSP00000427401.3; ENSG00000153006.16.
DR GeneID; 285672; -.
DR KEGG; hsa:285672; -.
DR MANE-Select; ENST00000513458.9; ENSP00000427401.3; NM_173829.4; NP_776190.1.
DR UCSC; uc003jtk.4; human.
DR CTD; 285672; -.
DR DisGeNET; 285672; -.
DR GeneCards; SREK1IP1; -.
DR HGNC; HGNC:26716; SREK1IP1.
DR HPA; ENSG00000153006; Low tissue specificity.
DR neXtProt; NX_Q8N9Q2; -.
DR OpenTargets; ENSG00000153006; -.
DR PharmGKB; PA162402954; -.
DR VEuPathDB; HostDB:ENSG00000153006; -.
DR eggNOG; KOG2985; Eukaryota.
DR GeneTree; ENSGT00510000047710; -.
DR HOGENOM; CLU_122662_0_0_1; -.
DR InParanoid; Q8N9Q2; -.
DR OMA; KHHKKRQ; -.
DR OrthoDB; 1616223at2759; -.
DR PhylomeDB; Q8N9Q2; -.
DR TreeFam; TF318225; -.
DR PathwayCommons; Q8N9Q2; -.
DR SignaLink; Q8N9Q2; -.
DR BioGRID-ORCS; 285672; 31 hits in 1005 CRISPR screens.
DR ChiTaRS; SREK1IP1; human.
DR GenomeRNAi; 285672; -.
DR Pharos; Q8N9Q2; Tdark.
DR PRO; PR:Q8N9Q2; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q8N9Q2; protein.
DR Bgee; ENSG00000153006; Expressed in buccal mucosa cell and 208 other tissues.
DR Genevisible; Q8N9Q2; HS.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR InterPro; IPR001878; Znf_CCHC.
DR PROSITE; PS50158; ZF_CCHC; 1.
PE 1: Evidence at protein level;
KW Metal-binding; mRNA processing; mRNA splicing; Phosphoprotein;
KW Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..155
FT /note="Protein SREK1IP1"
FT /id="PRO_0000311922"
FT ZN_FING 13..30
FT /note="CCHC-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00047"
FT REGION 44..155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..81
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..110
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..143
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 52
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:20068231"
FT MOD_RES 96
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q4V9W2"
FT MOD_RES 97
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q4V9W2"
FT MOD_RES 146
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:23186163"
SQ SEQUENCE 155 AA; 18177 MW; 9BABECE4783AFF27 CRC64;
MAVPGCNKDS VRAGCKKCGY PGHLTFECRN FLRVDPKRDI VLDVSSTSSE DSDEENEELN
KLQALQEKRI NEEEEKKKEK SKEKIKLKKK RKRSYSSSST EEDTSKQKKQ KYQKKEKKKE
KKSKSKKGKH HKKEKKKRKK EKHSSTPNSS EFSRK
