SR1IP_MOUSE
ID SR1IP_MOUSE Reviewed; 153 AA.
AC Q4V9W2; Q05CD6; Q8CGG6; Q9CRM9; Q9CRR4; Q9CXR0;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Protein SREK1IP1;
DE AltName: Full=SFRS12-interacting protein 1;
DE AltName: Full=SREK1-interacting protein 1;
GN Name=Srek1ip1; Synonyms=Sfrs12ip1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Head, and Muellerian duct;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Brain, Eye, Mammary gland, and Thymus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-96 AND SER-97, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Heart, Kidney, Liver, Lung, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Possible splicing regulator involved in the control of
CC cellular survival. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with SREK1/SFRS12. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q4V9W2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q4V9W2-2; Sequence=VSP_029642;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB29157.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
CC Sequence=BAB31175.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK014102; BAB29157.1; ALT_SEQ; mRNA.
DR EMBL; AK018357; BAB31175.1; ALT_SEQ; mRNA.
DR EMBL; AK020113; BAB31999.3; -; mRNA.
DR EMBL; BC027133; AAH27133.1; -; mRNA.
DR EMBL; BC038302; AAH38302.1; -; mRNA.
DR EMBL; BC096661; AAH96661.1; -; mRNA.
DR EMBL; BC116993; AAI16994.1; -; mRNA.
DR EMBL; BC116999; AAI17000.1; -; mRNA.
DR CCDS; CCDS26753.1; -. [Q4V9W2-1]
DR RefSeq; NP_080351.2; NM_026075.3. [Q4V9W2-1]
DR AlphaFoldDB; Q4V9W2; -.
DR STRING; 10090.ENSMUSP00000022230; -.
DR iPTMnet; Q4V9W2; -.
DR PhosphoSitePlus; Q4V9W2; -.
DR EPD; Q4V9W2; -.
DR jPOST; Q4V9W2; -.
DR MaxQB; Q4V9W2; -.
DR PaxDb; Q4V9W2; -.
DR PeptideAtlas; Q4V9W2; -.
DR PRIDE; Q4V9W2; -.
DR ProteomicsDB; 261651; -. [Q4V9W2-1]
DR ProteomicsDB; 261652; -. [Q4V9W2-2]
DR Antibodypedia; 23725; 53 antibodies from 15 providers.
DR Ensembl; ENSMUST00000022230; ENSMUSP00000022230; ENSMUSG00000021716. [Q4V9W2-1]
DR Ensembl; ENSMUST00000156105; ENSMUSP00000122592; ENSMUSG00000021716. [Q4V9W2-2]
DR GeneID; 67288; -.
DR KEGG; mmu:67288; -.
DR UCSC; uc007rtm.1; mouse. [Q4V9W2-1]
DR CTD; 285672; -.
DR MGI; MGI:1914538; Srek1ip1.
DR VEuPathDB; HostDB:ENSMUSG00000021716; -.
DR eggNOG; KOG2985; Eukaryota.
DR GeneTree; ENSGT00510000047710; -.
DR HOGENOM; CLU_122662_0_0_1; -.
DR InParanoid; Q4V9W2; -.
DR OMA; KHHKKRQ; -.
DR OrthoDB; 1601271at2759; -.
DR TreeFam; TF318225; -.
DR BioGRID-ORCS; 67288; 2 hits in 59 CRISPR screens.
DR ChiTaRS; Srek1ip1; mouse.
DR PRO; PR:Q4V9W2; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q4V9W2; protein.
DR Bgee; ENSMUSG00000021716; Expressed in animal zygote and 253 other tissues.
DR Genevisible; Q4V9W2; MM.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR InterPro; IPR001878; Znf_CCHC.
DR PROSITE; PS50158; ZF_CCHC; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Metal-binding; mRNA processing; mRNA splicing;
KW Phosphoprotein; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..153
FT /note="Protein SREK1IP1"
FT /id="PRO_0000311923"
FT ZN_FING 13..30
FT /note="CCHC-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00047"
FT REGION 44..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..81
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..109
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 110..142
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 52
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N9Q2"
FT MOD_RES 96
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 97
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT VAR_SEQ 69..153
FT /note="RINEEEEKKKEKSREKIKLKKRRKRSYSSATEEDSAKQKKQKYQKKEKKKEK
FT KNKSKKGKHHKKEKKKRKKEKRSSPYHSELTKK -> SKPWFLPTVLF (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_029642"
FT CONFLICT 119
FT /note="E -> K (in Ref. 2; AAH38302)"
FT /evidence="ECO:0000305"
FT CONFLICT 139..140
FT /note="KE -> RG (in Ref. 1; BAB29157)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 153 AA; 18151 MW; B42AA17FBC299448 CRC64;
MAVPGCNKDN VRAGCRKCGY PGHLTFECRN FLRVDPKRDI VLDVSSTSSE DSDEENEELN
KLQALQEKRI NEEEEKKKEK SREKIKLKKR RKRSYSSATE EDSAKQKKQK YQKKEKKKEK
KNKSKKGKHH KKEKKKRKKE KRSSPYHSEL TKK
