SRA10_CAEEL
ID SRA10_CAEEL Reviewed; 336 AA.
AC Q20405; Q7JMP2;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Serpentine receptor class alpha-10;
DE Short=Protein sra-10;
GN Name=sra-10; ORFNames=F44F4.5;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP TISSUE SPECIFICITY.
RX PubMed=7585938; DOI=10.1016/0092-8674(95)90162-0;
RA Troemel E.R., Chou J.H., Dwyer N.D., Colbert H.A., Bargmann C.I.;
RT "Divergent seven transmembrane receptors are candidate chemosensory
RT receptors in C. elegans.";
RL Cell 83:207-218(1995).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a;
CC IsoId=Q20405-1; Sequence=Displayed;
CC Name=b;
CC IsoId=Q20405-2; Sequence=VSP_020526;
CC -!- TISSUE SPECIFICITY: Expressed in the URX sensory neuron, the ALA
CC interneuron and in additional interneurons, pharyngeal neurons and
CC muscle. {ECO:0000269|PubMed:7585938}.
CC -!- SIMILARITY: Belongs to the nematode receptor-like protein sra family.
CC {ECO:0000305}.
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DR EMBL; Z37092; CAA85456.1; -; Genomic_DNA.
DR EMBL; Z37092; CAE46667.1; -; Genomic_DNA.
DR PIR; T22187; T22187.
DR RefSeq; NP_001022162.1; NM_001026991.1. [Q20405-1]
DR RefSeq; NP_001022163.1; NM_001026992.1. [Q20405-2]
DR AlphaFoldDB; Q20405; -.
DR PaxDb; Q20405; -.
DR EnsemblMetazoa; F44F4.5a.1; F44F4.5a.1; WBGene00005036. [Q20405-1]
DR EnsemblMetazoa; F44F4.5b.1; F44F4.5b.1; WBGene00005036. [Q20405-2]
DR GeneID; 191781; -.
DR KEGG; cel:CELE_F44F4.5; -.
DR UCSC; F44F4.5a; c. elegans. [Q20405-1]
DR CTD; 191781; -.
DR WormBase; F44F4.5a; CE01001; WBGene00005036; sra-10. [Q20405-1]
DR WormBase; F44F4.5b; CE35537; WBGene00005036; sra-10. [Q20405-2]
DR eggNOG; ENOG502THB2; Eukaryota.
DR GeneTree; ENSGT00970000195848; -.
DR InParanoid; Q20405; -.
DR OMA; CEIMRTT; -.
DR OrthoDB; 1109097at2759; -.
DR PhylomeDB; Q20405; -.
DR PRO; PR:Q20405; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00005036; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0004930; F:G protein-coupled receptor activity; TAS:UniProtKB.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0050907; P:detection of chemical stimulus involved in sensory perception; IBA:GO_Central.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; TAS:UniProtKB.
DR InterPro; IPR000344; 7TM_GPCR_serpentine_rcpt_Sra.
DR Pfam; PF02117; 7TM_GPCR_Sra; 1.
DR PRINTS; PR00697; TMPROTEINSRA.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..336
FT /note="Serpentine receptor class alpha-10"
FT /id="PRO_0000104476"
FT TOPO_DOM 1..28
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..61
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 83..107
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 108..128
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 129..148
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 149..169
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 170..192
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 193..213
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 214..243
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 265..280
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 281..301
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 302..336
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT VAR_SEQ 223..224
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_020526"
SQ SEQUENCE 336 AA; 38011 MW; D5184D24C267FCD0 CRC64;
MGPITANSSK CATEDQMILQ TSLLLRINVI IMTIVAIITF ILTYKALFIL KIRPIFHSST
KILLYTSLLF VNVHAVIFMV IQNTALIRSF TLSDKPCEIM RTTLECRFQN HVLIFGIAGV
NFNQFGLTVD RLLATIIPQS YSHMGALPGV ILSVLVVACS IAAPLIIAIG DPYDDIVPNC
FFFPEHSAPR ANIFLVTLST LVITSIFLNF IIIYANKKLE KGCRTRFYVT QRYQKREALI
STRIISYIAA SQFLGLTLYS TMVLTLRLHK SMIPISIYHN MVWWAYTVPF AAVSLPALLI
YRINQVGSNR KRVINRITAK VETQEEHMKS LKELWA
