SRA11_CAEEL
ID SRA11_CAEEL Reviewed; 334 AA.
AC Q20411;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2004, sequence version 2.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Serpentine receptor class alpha-11;
DE Short=Protein sra-11;
GN Name=sra-11; ORFNames=F44F4.13;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP TISSUE SPECIFICITY.
RX PubMed=7585938; DOI=10.1016/0092-8674(95)90162-0;
RA Troemel E.R., Chou J.H., Dwyer N.D., Colbert H.A., Bargmann C.I.;
RT "Divergent seven transmembrane receptors are candidate chemosensory
RT receptors in C. elegans.";
RL Cell 83:207-218(1995).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=11493519; DOI=10.1242/dev.128.11.1951;
RA Altun-Gultekin Z., Andachi Y., Tsalik E.L., Pilgrim D., Kohara Y.,
RA Hobert O.;
RT "A regulatory cascade of three homeobox genes, ceh-10, ttx-3 and ceh-23,
RT controls cell fate specification of a defined interneuron class in C.
RT elegans.";
RL Development 128:1951-1969(2001).
RN [4]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=16051801; DOI=10.1126/science.1114209;
RA Remy J.J., Hobert O.;
RT "An interneuronal chemoreceptor required for olfactory imprinting in C.
RT elegans.";
RL Science 309:787-790(2005).
CC -!- FUNCTION: A G protein-coupled receptor required for olfactory
CC imprinting a requisite in ordorant response such as benzaldehyde and
CC isoamylalcohol. {ECO:0000269|PubMed:16051801}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in interneurons AIY and AVB in L1 larvae.
CC In adults, strong expression is seen in AIY and AIA but only weak
CC expression in AVB. {ECO:0000269|PubMed:11493519,
CC ECO:0000269|PubMed:7585938}.
CC -!- DISRUPTION PHENOTYPE: Worms exhibit olfactory imprinting to
CC benzaldehyde and isoamylalcohol. {ECO:0000269|PubMed:16051801}.
CC -!- SIMILARITY: Belongs to the nematode receptor-like protein sra family.
CC {ECO:0000305}.
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DR EMBL; Z37092; CAA85461.2; -; Genomic_DNA.
DR PIR; T22192; T22192.
DR RefSeq; NP_496348.2; NM_063947.2.
DR AlphaFoldDB; Q20411; -.
DR STRING; 6239.F44F4.13; -.
DR PaxDb; Q20411; -.
DR EnsemblMetazoa; F44F4.13.1; F44F4.13.1; WBGene00005037.
DR GeneID; 191782; -.
DR KEGG; cel:CELE_F44F4.13; -.
DR UCSC; F44F4.13; c. elegans.
DR CTD; 191782; -.
DR WormBase; F44F4.13; CE33395; WBGene00005037; sra-11.
DR eggNOG; ENOG502TFIZ; Eukaryota.
DR GeneTree; ENSGT00970000195848; -.
DR HOGENOM; CLU_048025_0_1_1; -.
DR InParanoid; Q20411; -.
DR OMA; SAMTIDR; -.
DR OrthoDB; 1193026at2759; -.
DR PhylomeDB; Q20411; -.
DR PRO; PR:Q20411; -.
DR Proteomes; UP000001940; Chromosome II.
DR GO; GO:0016021; C:integral component of membrane; TAS:UniProtKB.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; TAS:UniProtKB.
DR GO; GO:0050907; P:detection of chemical stimulus involved in sensory perception; IMP:UniProtKB.
DR GO; GO:0008355; P:olfactory learning; IMP:UniProtKB.
DR InterPro; IPR000344; 7TM_GPCR_serpentine_rcpt_Sra.
DR Pfam; PF02117; 7TM_GPCR_Sra; 1.
DR PRINTS; PR00697; TMPROTEINSRA.
PE 2: Evidence at transcript level;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..334
FT /note="Serpentine receptor class alpha-11"
FT /id="PRO_0000104477"
FT TOPO_DOM 1..23
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..44
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 45..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..80
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 81..105
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..126
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 127..145
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..166
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 167..191
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 192..212
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 213..239
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..277
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 278..298
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 299..334
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 334 AA; 38358 MW; 5BB201A2D936188F CRC64;
MTTNNPVCAS DAHMEMYSSK LYTSALFLNL IIATTSMILT GFAIQKLFME SIINISTRMF
LFCGLMCCSL HQTAYIVLRI QVIYQVFFKL SEPCNLYYPA IDCKYVTFSL VAGNTGMIFI
QSAMTIDRIF ATIFPKLWPK LKYWPGVVLS ILMIACNYAN VQIIFWGDPL TEYVPTCGQF
PSKSVNRFQT FLAIALYMSI AHMVINVIIL YINVLQDRQQ SKSFNVNQRY QSREALKSSQ
AIFFLSMSQF FACLIYSVFT KVFLEFQLNL SPLQSGLVLA LSYTTPYACI AIPSLIIFTF
RFIKNQRLRN INELRSQTET GDECMRKIAK IWEK
