ID   SRA12_CAEBR             Reviewed;         326 AA.
AC   Q60T34; A8XY99;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   22-SEP-2009, sequence version 3.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Serpentine receptor class alpha-12;
DE            Short=Protein sra-12;
GN   Name=sra-12 {ECO:0000250|UniProtKB:Q20410}; ORFNames=CBG20641;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16 {ECO:0000269|PubMed:14624247};
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the nematode receptor-like protein sra family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAP37616.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; HE600991; CAP37616.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_002631485.1; XM_002631439.1.
DR   AlphaFoldDB; Q60T34; -.
DR   SMR; Q60T34; -.
DR   STRING; 6238.CBG20641; -.
DR   GeneID; 8573483; -.
DR   KEGG; cbr:CBG_20641; -.
DR   CTD; 8573483; -.
DR   WormBase; CBG20641; CBP47964; WBGene00039587; Cbr-sra-12.
DR   eggNOG; ENOG502TFXY; Eukaryota.
DR   HOGENOM; CLU_048025_0_1_1; -.
DR   InParanoid; Q60T34; -.
DR   OrthoDB; 1099769at2759; -.
DR   Proteomes; UP000008549; Chromosome II.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0050907; P:detection of chemical stimulus involved in sensory perception; IBA:GO_Central.
DR   InterPro; IPR000344; 7TM_GPCR_serpentine_rcpt_Sra.
DR   Pfam; PF02117; 7TM_GPCR_Sra; 1.
DR   PRINTS; PR00697; TMPROTEINSRA.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..326
FT                   /note="Serpentine receptor class alpha-12"
FT                   /id="PRO_0000273260"
FT   TOPO_DOM        1..17
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255, ECO:0000305"
FT   TRANSMEM        18..38
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        39..54
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255, ECO:0000305"
FT   TRANSMEM        55..75
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        76..101
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..122
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        123..138
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..159
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        160..185
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        186..206
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        207..234
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        235..255
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        256..270
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        271..291
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        292..326
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   326 AA;  37033 MW;  18E0210251532638 CRC64;
     MSCASEVQAQ LFTHPVQIIY ACVQTVLFLA TIIGSLLAIV QLCKKTTIPD STKVLLIGAL
     FFANAHELAY FSSPFKVFKM NLFHTNTSCY PLASTLECIP TTTVLAMGIS GNMLIQSALS
     IFRLLATIFP VCYSRMRALP GVVLLFMVLI PSFLSYSWIR SDIVLDDYQM FCSQWSANIS
     SRANTYLEYC SYLTVAHIII NALIILRNRS VESKCRFDVQ QRYLNSETLK TTQTICYLSI
     AQFLAMFLYS GGVLFMRKNQ KNIPTLIYIN VIVWVYAPPY ACVSLAPLIL FSLWNLKKQR
     QIRIQSITVQ KETQEDHIRK LQLSWG