SRA12_CAEEL
ID SRA12_CAEEL Reviewed; 327 AA.
AC Q20410; Q962C7;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2002, sequence version 2.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Serpentine receptor class alpha-12;
DE Short=Protein sra-12;
GN Name=sra-12; ORFNames=F44F4.7;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Bristol N2;
RX PubMed=11744632; DOI=10.1093/glycob/11.11.979;
RA Warren C.E., Krizus A., Dennis J.W.;
RT "Complementary expression patterns of six nonessential Caenorhabditis
RT elegans core 2/I N-acetylglucosaminyltransferase homologues.";
RL Glycobiology 11:979-988(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=15177025; DOI=10.1016/j.devcel.2004.05.004;
RA Wenick A.S., Hobert O.;
RT "Genomic cis-regulatory architecture and trans-acting regulators of a
RT single interneuron-specific gene battery in C. elegans.";
RL Dev. Cell 6:757-770(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in neurons RIF/RIG and PVT.
CC {ECO:0000269|PubMed:15177025}.
CC -!- SIMILARITY: Belongs to the nematode receptor-like protein sra family.
CC {ECO:0000305}.
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DR EMBL; AY037792; AAK94756.1; -; Transcribed_RNA.
DR EMBL; Z37092; CAA85460.2; -; Genomic_DNA.
DR PIR; T22191; T22191.
DR RefSeq; NP_496346.2; NM_063945.5.
DR AlphaFoldDB; Q20410; -.
DR SMR; Q20410; -.
DR STRING; 6239.F44F4.7; -.
DR EPD; Q20410; -.
DR PaxDb; Q20410; -.
DR EnsemblMetazoa; F44F4.7.1; F44F4.7.1; WBGene00005038.
DR GeneID; 3565216; -.
DR KEGG; cel:CELE_F44F4.7; -.
DR UCSC; F44F4.7; c. elegans.
DR CTD; 3565216; -.
DR WormBase; F44F4.7; CE30668; WBGene00005038; sra-12.
DR eggNOG; ENOG502TFXY; Eukaryota.
DR GeneTree; ENSGT00970000195848; -.
DR HOGENOM; CLU_048025_0_1_1; -.
DR InParanoid; Q20410; -.
DR OMA; YAPPYAC; -.
DR OrthoDB; 1099769at2759; -.
DR PhylomeDB; Q20410; -.
DR PRO; PR:Q20410; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00005038; Expressed in larva.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0050907; P:detection of chemical stimulus involved in sensory perception; IBA:GO_Central.
DR InterPro; IPR000344; 7TM_GPCR_serpentine_rcpt_Sra.
DR Pfam; PF02117; 7TM_GPCR_Sra; 1.
DR PRINTS; PR00697; TMPROTEINSRA.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..327
FT /note="Serpentine receptor class alpha-12"
FT /id="PRO_0000104478"
FT TOPO_DOM 1..18
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 19..39
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 40..53
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 54..74
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 75..98
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..119
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 120..138
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 160..185
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 186..206
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 207..234
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 235..255
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 256..270
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..291
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..327
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 327 AA; 37407 MW; FAEB1BB8184E3405 CRC64;
MGCASEIQAE IFTSFGQLFY ASFQTILFLA TIIGSLLAIF ELCKKTTVPD STRVLLIGSL
FFANAHEFAY FTAPLKVFQL NIFNTNTSCY PLISTRDCIP TTTVLAMGIS GNMLIQSALS
IDRLLATIFP FSYSRMRALP GFVLLIMVLI PAMFTYSWIR LDIVLDDYQM FCSQWSANIS
TRANTFLEIC SYLTVAHIII NCLIILRNRA IEKRCRFDVT QRYLTSENLK TTQAICYLSI
AQFLAMFMYS GGVLLMRKNR ENIPTLIYFN VIVWVYAPPY ACVSLAPLIL FSLWNLKKQR
HIQIKSVQSA QKETQDDYIR KLQKSWK
