ID   SRA13_CAEBR             Reviewed;         335 AA.
AC   Q627G6; A8WNA9;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Serpentine receptor class alpha-13;
DE            Short=Protein sra-13;
GN   Name=sra-13 {ECO:0000250|UniProtKB:Q20618}; ORFNames=CBG00681;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16 {ECO:0000269|PubMed:14624247};
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Chemosensory receptor that negatively regulates RAS/MAPK
CC       signaling during vulva induction and the negative regulation of
CC       olfaction of volitile attractants. Required for the suppression of
CC       vulval induction in response to food starvation. Signaling acts through
CC       the GPA-5 G-alpha protein subunit (By similarity).
CC       {ECO:0000250|UniProtKB:Q20618}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the nematode receptor-like protein sra family.
CC       {ECO:0000305}.
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DR   EMBL; HE600999; CAP21963.2; -; Genomic_DNA.
DR   AlphaFoldDB; Q627G6; -.
DR   EnsemblMetazoa; CBG00681.1; CBG00681.1; WBGene00024038.
DR   WormBase; CBG00681; CBP26562; WBGene00024038; Cbr-sra-13.
DR   eggNOG; ENOG502TH2W; Eukaryota.
DR   HOGENOM; CLU_048025_0_1_1; -.
DR   InParanoid; Q627G6; -.
DR   OMA; NHCGFYP; -.
DR   OrthoDB; 1258120at2759; -.
DR   Proteomes; UP000008549; Chromosome II.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0050907; P:detection of chemical stimulus involved in sensory perception; IBA:GO_Central.
DR   InterPro; IPR000344; 7TM_GPCR_serpentine_rcpt_Sra.
DR   Pfam; PF02117; 7TM_GPCR_Sra; 1.
DR   PRINTS; PR00697; TMPROTEINSRA.
PE   3: Inferred from homology;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..335
FT                   /note="Serpentine receptor class alpha-13"
FT                   /id="PRO_0000273261"
FT   TOPO_DOM        1..22
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255, ECO:0000305"
FT   TRANSMEM        23..43
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        44..61
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255, ECO:0000305"
FT   TRANSMEM        62..82
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        83..107
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255, ECO:0000305"
FT   TRANSMEM        108..128
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        129..149
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255, ECO:0000305"
FT   TRANSMEM        150..170
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        171..192
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255, ECO:0000305"
FT   TRANSMEM        193..213
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        214..235
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255, ECO:0000305"
FT   TRANSMEM        236..255
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        256..278
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255, ECO:0000305"
FT   TRANSMEM        279..299
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        300..335
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255, ECO:0000305"
SQ   SEQUENCE   335 AA;  38392 MW;  DE8072DC49AFCC98 CRC64;
     MAIVSSENRT CADEKLLALY QSWSYIASIV FNCLVPTIST YFLGRAIFQL CNQATIQYST
     RILLIATILF AACHQVSYFA FKIDLLHTMF FKLDQPCFLQ RSSYDCRFIS IAQTTGVVGM
     ALTGLAMSTD RALALTFPAD YHKLKSVPRV VLSVFVFIVS FSTWFLLTMN DPLTGYLNHC
     GFYPSYSVAN FQLMLDVILY LAIFNLIWDV ILFYYARQQI LWRRSYQFQK RYEARISLNC
     TQAVFVISIC QCISNGANSG LMRLLMMIGT SITSVTYSSL LSLFYTAPYS CILLPILMMR
     ISEYIREQRT IGILSLRSEK PGLEEHHQRM RAAWS