SRA13_CAEEL
ID SRA13_CAEEL Reviewed; 335 AA.
AC Q20618; Q7JM75;
DT 25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 2.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Serpentine receptor class alpha-13;
DE Short=Protein sra-13;
GN Name=sra-13; ORFNames=F49E12.5;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=12736202; DOI=10.1242/dev.00497;
RA Battu G., Hoier E.F., Hajnal A.;
RT "The C. elegans G-protein-coupled receptor SRA-13 inhibits RAS/MAPK
RT signalling during olfaction and vulval development.";
RL Development 130:2567-2577(2003).
CC -!- FUNCTION: Chemosensory receptor that negatively regulates RAS/MAPK
CC signaling during vulva induction and the negative regulation of
CC olfaction of volitile attractants. Required for the suppression of
CC vulval induction in response to food starvation. Signaling acts through
CC the GPA-5 G-alpha protein subunit. {ECO:0000269|PubMed:12736202}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a;
CC IsoId=Q20618-1; Sequence=Displayed;
CC Name=b;
CC IsoId=Q20618-2; Sequence=VSP_020527, VSP_020528, VSP_020529;
CC -!- TISSUE SPECIFICITY: Expressed in the AWA and AWC chemosensory neurons.
CC {ECO:0000269|PubMed:12736202}.
CC -!- SIMILARITY: Belongs to the nematode receptor-like protein sra family.
CC {ECO:0000305}.
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DR EMBL; Z66520; CAA91390.2; -; Genomic_DNA.
DR EMBL; Z66520; CAE48504.1; -; Genomic_DNA.
DR PIR; T22450; T22450.
DR RefSeq; NP_001022186.1; NM_001027015.1. [Q20618-1]
DR RefSeq; NP_001022187.1; NM_001027016.2.
DR AlphaFoldDB; Q20618; -.
DR STRING; 6239.F49E12.5a; -.
DR PaxDb; Q20618; -.
DR EnsemblMetazoa; F49E12.5a.1; F49E12.5a.1; WBGene00005039. [Q20618-1]
DR EnsemblMetazoa; F49E12.5b.1; F49E12.5b.1; WBGene00005039.
DR GeneID; 186058; -.
DR KEGG; cel:CELE_F49E12.5; -.
DR UCSC; F49E12.5b; c. elegans. [Q20618-1]
DR CTD; 186058; -.
DR WormBase; F49E12.5a; CE35552; WBGene00005039; sra-13. [Q20618-1]
DR WormBase; F49E12.5b; CE35877; WBGene00005039; sra-13.
DR eggNOG; ENOG502TH2W; Eukaryota.
DR GeneTree; ENSGT00970000195848; -.
DR HOGENOM; CLU_048025_0_1_1; -.
DR InParanoid; Q20618; -.
DR OMA; NHCGFYP; -.
DR OrthoDB; 1258120at2759; -.
DR PhylomeDB; Q20618; -.
DR SignaLink; Q20618; -.
DR PRO; PR:Q20618; -.
DR Proteomes; UP000001940; Chromosome II.
DR GO; GO:0016021; C:integral component of membrane; IC:UniProtKB.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0004984; F:olfactory receptor activity; IMP:UniProtKB.
DR GO; GO:0050907; P:detection of chemical stimulus involved in sensory perception; IBA:GO_Central.
DR GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IMP:UniProtKB.
DR GO; GO:0046580; P:negative regulation of Ras protein signal transduction; IMP:UniProtKB.
DR GO; GO:0032096; P:negative regulation of response to food; IMP:UniProtKB.
DR GO; GO:0040027; P:negative regulation of vulval development; IMP:UniProtKB.
DR InterPro; IPR000344; 7TM_GPCR_serpentine_rcpt_Sra.
DR Pfam; PF02117; 7TM_GPCR_Sra; 1.
DR PRINTS; PR00697; TMPROTEINSRA.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Olfaction; Receptor; Reference proteome;
KW Sensory transduction; Transmembrane; Transmembrane helix.
FT CHAIN 1..335
FT /note="Serpentine receptor class alpha-13"
FT /id="PRO_0000104479"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..61
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 83..108
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 109..129
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 130..146
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..167
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 168..192
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 193..213
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 214..243
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 265..278
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 279..299
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 300..335
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1
FT /note="M -> MATPSSTNSDISTTQ (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_020527"
FT VAR_SEQ 157..159
FT /note="LSI -> AVI (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_020528"
FT VAR_SEQ 160..335
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_020529"
SQ SEQUENCE 335 AA; 38522 MW; ADC17A6015DC2A37 CRC64;
MAIISSVNRT CASESLLELY RSYKYILSTS FNIIIPIISL FFLVYAIKQL CAQSIIQYST
RVLLITTILF AVCHQIAYFC FKADLLYTML FKLDQPCNLQ HSSYDCRFIT IATTTSNCGM
ALVQLAMSID RVFALKFNRV YYKLKSIPGI TLALITLSIS FSMFFILTID DPLSGYVNHC
GFYPTYSQDK FHIFLDVTLY LAVFNFVFDI GLMYYSYQEI LWKRSYSFVN RFQSRISLKC
TQAIFIISIC QCISNVLYSG LLSLLMKLGR YMSSADYNLS LSLAYTTPYS CLILPILICK
VLEYIKKQRT VGILSLRNQK QSMEGHMAMI NSAWK
