ID   SRAC1_MACFA             Reviewed;         531 AA.
AC   Q95JR3; Q95K13;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Protein SERAC1;
DE   AltName: Full=Serine active site-containing protein 1;
GN   Name=SERAC1; ORFNames=QtsA-14245;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the phosphatidylglycerol
CC       remodeling that is essential for both mitochondrial function and
CC       intracellular cholesterol trafficking. May catalyze the remodeling of
CC       phosphatidylglycerol and be involved in the transacylation-acylation
CC       reaction to produce phosphatidylglycerol-36:1. May be involved in
CC       bis(monoacylglycerol)phosphate biosynthetic pathway (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}. Endoplasmic reticulum {ECO:0000250}.
CC       Mitochondrion {ECO:0000250}. Note=Localizes at the endoplasmic
CC       reticulum and at the endoplasmic reticulum-mitochondria interface.
CC       {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q95JR3-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q95JR3-2; Sequence=VSP_022861, VSP_022862, VSP_022863;
CC   -!- SIMILARITY: Belongs to the SERAC1 family. {ECO:0000305}.
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DR   EMBL; AB070014; BAB62959.1; -; mRNA.
DR   EMBL; AB070116; BAB63061.1; -; mRNA.
DR   AlphaFoldDB; Q95JR3; -.
DR   SMR; Q95JR3; -.
DR   STRING; 9541.XP_005552260.1; -.
DR   eggNOG; KOG2029; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Endoplasmic reticulum; Lipid biosynthesis;
KW   Lipid metabolism; Membrane; Mitochondrion; Phospholipid biosynthesis;
KW   Phospholipid metabolism; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..531
FT                   /note="Protein SERAC1"
FT                   /id="PRO_0000274672"
FT   TRANSMEM        33..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         1..70
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_022861"
FT   VAR_SEQ         436..478
FT                   /note="KTWLAKDCPALRIISVEYDTTLSDWRARCPMERRSLLSISSGI -> FPICD
FT                   FPGACRRGTAGSEGRATINSAHHKNAIKRVPKIERRMN (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_022862"
FT   VAR_SEQ         479..531
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_022863"
FT   CONFLICT        390
FT                   /note="R -> Q (in Ref. 1; BAB62959)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   531 AA;  60226 MW;  19C62D9B4DF99A62 CRC64;
     MSLAAYCVIC CRRVGTSTSP PKSGTRWRDI RNIIKFTGSL ILGGSLFLTY EVLALKKAVT
     LDTQVVEREK MKSYIYVHTV SLDKGENHGI AWQARKELHK AVRKVLATSA KILRNPFADP
     FSTVDIEDHE CAVWLLLRKS KSDDKTTRLE AVQEMSEAHH WHDYQYRLIA QACDPKTLIG
     LARSKESDLR FFLLPPPLPS LKEDSSTEEE LRQLLASLPQ TELDECIQYF TSLALSESSQ
     SLAAQKGGLW CFGGNGLPYA ESFGEVPSAT VEMFCLEAIV KHSEISTHCD KIEANGGLQL
     LQRLYQLHKD CPKVQRNIMR IIGNMALNEH LHSSIVRSGW VSIMAEAMKS DRIMEASHAA
     RILANLDRET VQEKYQDGVY VLHPQYRTSR PIKADVLFIH GLMGAAFKTW RQQDSEQAVI
     EKPMEEEDRY TTCWPKTWLA KDCPALRIIS VEYDTTLSDW RARCPMERRS LLSISSGIGE
     VLESPLHSEA TNFLGSSELL VLGIGRWFGY HIAWEVFSSK RCCWKPLRSQ K