SRARP_HUMAN
ID SRARP_HUMAN Reviewed; 169 AA.
AC Q8NEQ6; B3KXI9;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Steroid receptor-associated and regulated protein {ECO:0000312|HGNC:HGNC:28339};
DE AltName: Full=Estrogen receptor-related factor {ECO:0000303|PubMed:22341523};
DE Short=ER-related factor {ECO:0000303|PubMed:22341523};
DE AltName: Full=Steroid receptor-regulated protein {ECO:0000303|PubMed:28915724};
GN Name=SRARP {ECO:0000312|HGNC:HGNC:28339};
GN Synonyms=C1orf64, ERRF {ECO:0000303|PubMed:22341523},
GN SSPR {ECO:0000303|PubMed:28915724};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Thalamus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Prostate;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP VARIANTS [LARGE SCALE ANALYSIS] TRP-52 AND TRP-100.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
RN [6]
RP TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=22341523; DOI=10.1016/j.ajpath.2011.11.025;
RA Su D., Fu X., Fan S., Wu X., Wang X.X., Fu L., Dong X.Y., Ni J.J., Fu L.,
RA Zhu Z., Dong J.T.;
RT "Role of ERRF, a novel ER-related nuclear factor, in the growth control of
RT ER-positive human breast cancer cells.";
RL Am. J. Pathol. 180:1189-1201(2012).
RN [7]
RP FUNCTION.
RX PubMed=27125460; DOI=10.1016/j.bbrc.2016.04.132;
RA Luo A., Zhang X.;
RT "ERRF is essential for estrogen-estrogen receptor alpha signaling pathway
RT in ER positive breast cancer cells.";
RL Biochem. Biophys. Res. Commun. 474:400-405(2016).
RN [8]
RP TISSUE SPECIFICITY, INTERACTION WITH 14-3-3 PROTEINS, AND FUNCTION.
RX PubMed=28915724; DOI=10.18632/oncotarget.17826;
RA Naderi A.;
RT "C1orf64 is a novel androgen receptor target gene and coregulator that
RT interacts with 14-3-3 protein in breast cancer.";
RL Oncotarget 8:57907-57933(2017).
CC -!- FUNCTION: May regulate the transcriptional function of androgen and
CC estrogen receptors. {ECO:0000269|PubMed:22341523,
CC ECO:0000269|PubMed:28915724}.
CC -!- SUBUNIT: Interacts with 14-3-3 proteins (PubMed:28915724).
CC {ECO:0000269|PubMed:28915724}.
CC -!- INTERACTION:
CC Q8NEQ6; Q8N9N5-2: BANP; NbExp=3; IntAct=EBI-17858294, EBI-11524452;
CC Q8NEQ6; Q53EP0-3: FNDC3B; NbExp=3; IntAct=EBI-17858294, EBI-10242151;
CC Q8NEQ6; Q16656-4: NRF1; NbExp=3; IntAct=EBI-17858294, EBI-11742836;
CC Q8NEQ6; Q2TAL8: QRICH1; NbExp=3; IntAct=EBI-17858294, EBI-2798044;
CC Q8NEQ6; O76024: WFS1; NbExp=3; IntAct=EBI-17858294, EBI-720609;
CC -!- TISSUE SPECIFICITY: Expressed in breast tumors with a higher expression
CC level in estrogen receptor-positive cancers (PubMed:22341523,
CC PubMed:28915724). {ECO:0000269|PubMed:22341523,
CC ECO:0000269|PubMed:28915724}.
CC -!- INDUCTION: Up-regulated in breast cancers (PubMed:22341523).
CC {ECO:0000269|PubMed:22341523}.
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DR EMBL; AK127425; BAG54501.1; -; mRNA.
DR EMBL; AL355994; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471167; EAW51759.1; -; Genomic_DNA.
DR EMBL; BC017946; AAH17946.1; -; mRNA.
DR CCDS; CCDS166.1; -.
DR RefSeq; NP_849162.1; NM_178840.3.
DR AlphaFoldDB; Q8NEQ6; -.
DR BioGRID; 127222; 8.
DR IntAct; Q8NEQ6; 6.
DR STRING; 9606.ENSP00000332162; -.
DR iPTMnet; Q8NEQ6; -.
DR PhosphoSitePlus; Q8NEQ6; -.
DR BioMuta; SRARP; -.
DR DMDM; 74751258; -.
DR MassIVE; Q8NEQ6; -.
DR PaxDb; Q8NEQ6; -.
DR PeptideAtlas; Q8NEQ6; -.
DR PRIDE; Q8NEQ6; -.
DR Antibodypedia; 14459; 84 antibodies from 20 providers.
DR DNASU; 149563; -.
DR Ensembl; ENST00000329454.2; ENSP00000332162.2; ENSG00000183888.4.
DR GeneID; 149563; -.
DR KEGG; hsa:149563; -.
DR MANE-Select; ENST00000329454.2; ENSP00000332162.2; NM_178840.4; NP_849162.1.
DR UCSC; uc001axn.4; human.
DR CTD; 149563; -.
DR DisGeNET; 149563; -.
DR GeneCards; SRARP; -.
DR HGNC; HGNC:28339; SRARP.
DR HPA; ENSG00000183888; Tissue enhanced (brain, breast, choroid plexus).
DR MIM; 619448; gene.
DR neXtProt; NX_Q8NEQ6; -.
DR OpenTargets; ENSG00000183888; -.
DR PharmGKB; PA142672514; -.
DR VEuPathDB; HostDB:ENSG00000183888; -.
DR eggNOG; ENOG502TD74; Eukaryota.
DR GeneTree; ENSGT00390000000265; -.
DR HOGENOM; CLU_110067_0_0_1; -.
DR InParanoid; Q8NEQ6; -.
DR OMA; HLTFIID; -.
DR OrthoDB; 1598773at2759; -.
DR PhylomeDB; Q8NEQ6; -.
DR TreeFam; TF338217; -.
DR PathwayCommons; Q8NEQ6; -.
DR SignaLink; Q8NEQ6; -.
DR BioGRID-ORCS; 149563; 18 hits in 1045 CRISPR screens.
DR GenomeRNAi; 149563; -.
DR Pharos; Q8NEQ6; Tbio.
DR PRO; PR:Q8NEQ6; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8NEQ6; protein.
DR Bgee; ENSG00000183888; Expressed in medial globus pallidus and 91 other tissues.
DR Genevisible; Q8NEQ6; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0030331; F:nuclear estrogen receptor binding; IPI:UniProtKB.
DR GO; GO:0033148; P:positive regulation of intracellular estrogen receptor signaling pathway; IMP:UniProtKB.
DR InterPro; IPR027852; C1ORF64.
DR PANTHER; PTHR38494; PTHR38494; 1.
DR Pfam; PF15547; C1ORF64; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..169
FT /note="Steroid receptor-associated and regulated protein"
FT /id="PRO_0000247124"
FT VARIANT 52
FT /note="G -> W (in a breast cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_035491"
FT VARIANT 100
FT /note="G -> W (in a breast cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_035492"
FT VARIANT 112
FT /note="L -> F (in dbSNP:rs34950166)"
FT /id="VAR_033654"
SQ SEQUENCE 169 AA; 17657 MW; 53902A504A22451D CRC64;
MAPSEDPRDW RANLKGTIRE TGLETSSGGK LAGHQKTVPT AHLTFVIDCT HGKQLSLAAT
ASPPQAPSPN RGLVTPPMKT YIVFCGENWP HLTRVTPMGG GCLAQARATL PLCRGSVASA
SFPVSPLCPQ EVPEAKGKPV KAAPVRSSTW GTVKDSLKAL SSCVCGQAD
