SRARP_MOUSE
ID SRARP_MOUSE Reviewed; 163 AA.
AC Q3ULG3;
DT 22-NOV-2017, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Steroid receptor-associated and regulated protein;
GN Name=Srarp {ECO:0000312|MGI:MGI:2685540};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May regulate the transcriptional function of androgen and
CC estrogen receptors. {ECO:0000250|UniProtKB:Q8NEQ6}.
CC -!- SUBUNIT: Interacts with 14-3-3 proteins.
CC {ECO:0000250|UniProtKB:Q8NEQ6}.
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DR EMBL; AK145525; BAE26485.1; -; mRNA.
DR EMBL; AL670285; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466615; EDL13374.1; -; Genomic_DNA.
DR EMBL; BC147054; AAI47055.1; -; mRNA.
DR EMBL; BC147055; AAI47056.1; -; mRNA.
DR CCDS; CCDS51347.1; -.
DR RefSeq; NP_001028546.1; NM_001033374.3.
DR AlphaFoldDB; Q3ULG3; -.
DR STRING; 10090.ENSMUSP00000092122; -.
DR iPTMnet; Q3ULG3; -.
DR PhosphoSitePlus; Q3ULG3; -.
DR PaxDb; Q3ULG3; -.
DR PRIDE; Q3ULG3; -.
DR Antibodypedia; 14459; 84 antibodies from 20 providers.
DR Ensembl; ENSMUST00000094544; ENSMUSP00000092122; ENSMUSG00000070637.
DR GeneID; 277744; -.
DR KEGG; mmu:277744; -.
DR UCSC; uc008vok.2; mouse.
DR CTD; 149563; -.
DR MGI; MGI:2685540; Srarp.
DR VEuPathDB; HostDB:ENSMUSG00000070637; -.
DR eggNOG; ENOG502TD74; Eukaryota.
DR GeneTree; ENSGT00390000000265; -.
DR HOGENOM; CLU_110067_0_0_1; -.
DR InParanoid; Q3ULG3; -.
DR OMA; HLTFIID; -.
DR OrthoDB; 1598773at2759; -.
DR PhylomeDB; Q3ULG3; -.
DR TreeFam; TF338217; -.
DR BioGRID-ORCS; 277744; 2 hits in 65 CRISPR screens.
DR ChiTaRS; Srarp; mouse.
DR PRO; PR:Q3ULG3; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q3ULG3; protein.
DR Bgee; ENSMUSG00000070637; Expressed in morula and 31 other tissues.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0030331; F:nuclear estrogen receptor binding; ISO:MGI.
DR GO; GO:0033148; P:positive regulation of intracellular estrogen receptor signaling pathway; ISS:UniProtKB.
DR InterPro; IPR027852; C1ORF64.
DR PANTHER; PTHR38494; PTHR38494; 1.
DR Pfam; PF15547; C1ORF64; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..163
FT /note="Steroid receptor-associated and regulated protein"
FT /id="PRO_0000442318"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 96..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..28
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 163 AA; 17055 MW; 518E4120053D03B1 CRC64;
MAFSKDPRRT SLRDSSVEMS SGTQPSCAPK AMPTAHVTFL IDCATGKQVS LAASTAPPHA
SRANQGCVAP PMKTFVMFRG KTTMLGTQNI SLSRGALDGA KDTLPPYRGL GAPHSLPASL
PGPQNDPKAQ GSSLKPGATE KHSTREKVKH SLKALTCLCG QVE
