ID   SRA_MYCLE               Reviewed;         408 AA.
AC   Q07297;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Serine-rich antigen;
DE   AltName: Full=25L;
DE   AltName: Full=45 kDa protein;
GN   Name=sra; OrderedLocusNames=ML0411; ORFNames=MLCL383.14;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8478104; DOI=10.1128/iai.61.5.2145-2153.1993;
RA   Vega-Lopez F., Brooks L.A., Dockrell H.M., de Smet K.A.L., Thompson J.K.,
RA   Hussain R., Stoker N.G.;
RT   "Sequence and immunological characterization of a serine-rich antigen from
RT   Mycobacterium leprae.";
RL   Infect. Immun. 61:2145-2153(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7934845; DOI=10.1111/j.1365-2958.1993.tb00953.x;
RA   Rinke de Wit T.F., Clark-Curtiss J.E., Abebe F., Kolkon A.H.J.,
RA   Jonson A.A.M., Thole J.E.R.;
RT   "A Mycobacterium leprae-specific gene encoding an immunologically
RT   recognized 45 kDa protein.";
RL   Mol. Microbiol. 10:829-838(1993).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
CC   -!- SIMILARITY: Belongs to the mycobacterial PPE family. {ECO:0000305}.
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DR   EMBL; U00015; AAC43220.1; -; Genomic_DNA.
DR   EMBL; X68431; CAA48480.1; -; Genomic_DNA.
DR   EMBL; Z21952; CAA79950.1; -; Genomic_DNA.
DR   EMBL; Z97179; CAB09938.1; -; Genomic_DNA.
DR   EMBL; AL583918; CAC29919.1; -; Genomic_DNA.
DR   PIR; C86960; C86960.
DR   PIR; S33522; S33522.
DR   PIR; S39872; S39872.
DR   RefSeq; NP_301391.1; NC_002677.1.
DR   RefSeq; WP_010907715.1; NC_002677.1.
DR   AlphaFoldDB; Q07297; -.
DR   SMR; Q07297; -.
DR   STRING; 272631.ML0411; -.
DR   EnsemblBacteria; CAC29919; CAC29919; CAC29919.
DR   KEGG; mle:ML0411; -.
DR   PATRIC; fig|272631.5.peg.699; -.
DR   Leproma; ML0411; -.
DR   eggNOG; COG5651; Bacteria.
DR   HOGENOM; CLU_674089_0_0_11; -.
DR   OMA; DIVSGWA; -.
DR   Proteomes; UP000000806; Chromosome.
DR   Gene3D; 1.20.1260.20; -; 1.
DR   InterPro; IPR022171; PPE_C.
DR   InterPro; IPR000030; PPE_family.
DR   InterPro; IPR038332; PPE_sf.
DR   Pfam; PF00823; PPE; 1.
DR   Pfam; PF12484; PPE-SVP; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat.
FT   CHAIN           1..408
FT                   /note="Serine-rich antigen"
FT                   /id="PRO_0000072181"
FT   REPEAT          209..214
FT                   /note="1"
FT   REPEAT          230..235
FT                   /note="2"
FT   REGION          209..235
FT                   /note="2 X 6 AA repeats of S-V-A-Q-S-E"
FT   CONFLICT        132
FT                   /note="T -> S (in Ref. 2; CAA79950)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        189
FT                   /note="S -> L (in Ref. 2)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        191
FT                   /note="H -> D (in Ref. 2)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        292
FT                   /note="P -> L (in Ref. 2; CAA79950)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   408 AA;  42466 MW;  5C0C2BE0D6E6A9D8 CRC64;
     MFDFMVYSPE VNAFLMSRGP GSTPLWGAAE AWISLAEQLM EAAQEVSDTI VVAVPASFAG
     ETSDMLASRV STFVAWLDGN AENAGLIARV LHAVAYAFEE ARAGMVPLLT VLGNIIHTMA
     LKAINWFGQV STTVAALEAD YDLMWVQNST AMTTYRDTVL RETGKMENFE PAPQLVSRYC
     MDRRDSVNSF HSSSSSDSLY ESIDNLYDSV AQSEEHGSDS MSQSYNTCGS VAQSELCDSP
     FGTPSQSSQS NDLSATSLTQ QLGGLDSIIS SASASLLTTN SISSSTASSI MPIVASQVTE
     TLGRSQVAVE KMIQSISSTA VSVDVAASKV VAGVGQAVSV GALRVPENWA TASQPVMATA
     HSVPAGCSAI TTAVSGPLEG VTQPAEEVLT ASVAGGSGTG GPAFNEAV