SRB11_SCHPO
ID SRB11_SCHPO Reviewed; 228 AA.
AC O94503;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 136.
DE RecName: Full=RNA polymerase II holoenzyme cyclin-like subunit;
DE AltName: Full=Suppressor of RNA polymerase B srb11;
GN Name=srb11; ORFNames=SPBC12D12.06;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 5-228.
RX PubMed=15979093; DOI=10.1016/j.jmb.2005.05.041;
RA Hoeppner S., Baumli S., Cramer P.;
RT "Structure of the mediator subunit cyclin C and its implications for CDK8
RT function.";
RL J. Mol. Biol. 350:833-842(2005).
CC -!- FUNCTION: Component of the Cdk8 module/Srb8-11 module which is a
CC regulatory module of the Mediator complex that regulates basal RNA
CC polymerase II transcription. The Cdk8 module may sterically hinder the
CC interaction between Mediator and RNA polymerase II leading to
CC transcriptional repression of a subset of genes regulated by Mediator.
CC -!- SUBUNIT: Component of the Cdk8 module of the Mediator complex. The Cdk8
CC module is composed of srb8, srb9, srb10 and srb11.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the cyclin family. Cyclin C subfamily.
CC {ECO:0000305}.
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DR EMBL; CU329671; CAA22680.1; -; Genomic_DNA.
DR PIR; T39386; T39386.
DR RefSeq; NP_595953.1; NM_001021862.2.
DR PDB; 1ZP2; X-ray; 3.00 A; A=5-228.
DR PDBsum; 1ZP2; -.
DR AlphaFoldDB; O94503; -.
DR SMR; O94503; -.
DR BioGRID; 276206; 176.
DR STRING; 4896.SPBC12D12.06.1; -.
DR PaxDb; O94503; -.
DR EnsemblFungi; SPBC12D12.06.1; SPBC12D12.06.1:pep; SPBC12D12.06.
DR GeneID; 2539651; -.
DR KEGG; spo:SPBC12D12.06; -.
DR PomBase; SPBC12D12.06; srb11.
DR VEuPathDB; FungiDB:SPBC12D12.06; -.
DR eggNOG; KOG0794; Eukaryota.
DR HOGENOM; CLU_1215393_0_0_1; -.
DR InParanoid; O94503; -.
DR OMA; HIRTICN; -.
DR PhylomeDB; O94503; -.
DR EvolutionaryTrace; O94503; -.
DR PRO; PR:O94503; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0016592; C:mediator complex; IPI:PomBase.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IBA:GO_Central.
DR GO; GO:0003713; F:transcription coactivator activity; IC:PomBase.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0060261; P:positive regulation of transcription initiation from RNA polymerase II promoter; IC:PomBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00043; CYCLIN; 1.
DR InterPro; IPR013763; Cyclin-like.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR043198; Cyclin/Ssn8.
DR InterPro; IPR006671; Cyclin_N.
DR InterPro; IPR028367; CyclinC/Ssn8.
DR PANTHER; PTHR10026; PTHR10026; 1.
DR PANTHER; PTHR10026:SF7; PTHR10026:SF7; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR SMART; SM00385; CYCLIN; 2.
DR SUPFAM; SSF47954; SSF47954; 2.
PE 1: Evidence at protein level;
KW 3D-structure; Activator; Cyclin; Nucleus; Reference proteome; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1..228
FT /note="RNA polymerase II holoenzyme cyclin-like subunit"
FT /id="PRO_0000080427"
FT DOMAIN 10..134
FT /note="Cyclin N-terminal"
FT HELIX 9..11
FT /evidence="ECO:0007829|PDB:1ZP2"
FT HELIX 13..15
FT /evidence="ECO:0007829|PDB:1ZP2"
FT HELIX 30..45
FT /evidence="ECO:0007829|PDB:1ZP2"
FT HELIX 50..66
FT /evidence="ECO:0007829|PDB:1ZP2"
FT HELIX 75..89
FT /evidence="ECO:0007829|PDB:1ZP2"
FT HELIX 96..104
FT /evidence="ECO:0007829|PDB:1ZP2"
FT HELIX 115..128
FT /evidence="ECO:0007829|PDB:1ZP2"
FT TURN 129..131
FT /evidence="ECO:0007829|PDB:1ZP2"
FT HELIX 139..147
FT /evidence="ECO:0007829|PDB:1ZP2"
FT HELIX 153..166
FT /evidence="ECO:0007829|PDB:1ZP2"
FT TURN 167..170
FT /evidence="ECO:0007829|PDB:1ZP2"
FT HELIX 171..173
FT /evidence="ECO:0007829|PDB:1ZP2"
FT HELIX 177..189
FT /evidence="ECO:0007829|PDB:1ZP2"
FT HELIX 195..202
FT /evidence="ECO:0007829|PDB:1ZP2"
FT HELIX 205..222
FT /evidence="ECO:0007829|PDB:1ZP2"
FT STRAND 224..226
FT /evidence="ECO:0007829|PDB:1ZP2"
SQ SEQUENCE 228 AA; 26176 MW; 53DACF4A8A12FDC6 CRC64;
MAANYWASSQ LTQLFLSTDL ESLEPTCLSK DTIYQWKVVQ TFGDRLRLRQ RVLATAIVLL
RRYMLKKNEE KGFSLEALVA TCIYLSCKVE ECPVHIRTIC NEANDLWSLK VKLSRSNISE
IEFEIISVLD AFLIVHHPYT SLEQAFHDGI INQKQLEFAW SIVNDSYASS LCLMAHPHQL
AYAALLISCC NDENTIPKLL DLIKSTDAFK VILCVQRIIS IYYFEDIE
