SRB12_CAEEL
ID SRB12_CAEEL Reviewed; 350 AA.
AC A0A3B1DZW5; Q20962;
DT 08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT 05-DEC-2018, sequence version 1.
DT 03-AUG-2022, entry version 18.
DE RecName: Full=Serpentine receptor class beta-12 {ECO:0000312|WormBase:F58A6.10b};
DE Short=Protein srb-12 {ECO:0000305};
GN Name=srb-12 {ECO:0000312|WormBase:F58A6.10b};
GN ORFNames=F58A6.10 {ECO:0000312|WormBase:F58A6.10b};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=28662030; DOI=10.1371/journal.pbio.2002047;
RA Hoang H.D., Miller M.A.;
RT "Chemosensory and hyperoxia circuits in C. elegans males influence sperm
RT navigational capacity.";
RL PLoS Biol. 15:E2002047-E2002047(2017).
CC -!- FUNCTION: G-protein coupled receptor (Probable). Plays a role in the
CC navigational capacity of sperm and promotes the targeting of sperm
CC derived from males to the fertilization site in the uterus of
CC hermaphrodites (PubMed:28662030). {ECO:0000269|PubMed:28662030,
CC ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}. Perikaryon {ECO:0000269|PubMed:28662030}. Cell
CC projection, dendrite {ECO:0000269|PubMed:28662030}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=b {ECO:0000312|WormBase:F58A6.10b};
CC IsoId=A0A3B1DZW5-1; Sequence=Displayed;
CC Name=a {ECO:0000312|WormBase:F58A6.10a};
CC IsoId=A0A3B1DZW5-2; Sequence=VSP_060171;
CC -!- TISSUE SPECIFICITY: Expressed throughout the head.
CC {ECO:0000269|PubMed:28662030}.
CC -!- DISRUPTION PHENOTYPE: Abnormal distribution of male-derived sperm in
CC the hermaphrodite uterus following mating, with sperm accumulating at
CC the spermathecal-uterine valve 1 hour following mating.
CC {ECO:0000269|PubMed:28662030}.
CC -!- SIMILARITY: Belongs to the nematode receptor-like protein srb family.
CC {ECO:0000305}.
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DR EMBL; BX284602; CCD65840.1; -; Genomic_DNA.
DR EMBL; BX284602; VAY52132.1; -; Genomic_DNA.
DR PIR; T16497; T16497.
DR RefSeq; NP_494957.1; NM_062556.1. [A0A3B1DZW5-2]
DR AlphaFoldDB; A0A3B1DZW5; -.
DR STRING; 6239.F58A6.10; -.
DR EnsemblMetazoa; F58A6.10a.1; F58A6.10a.1; WBGene00019027. [A0A3B1DZW5-2]
DR EnsemblMetazoa; F58A6.10b.1; F58A6.10b.1; WBGene00019027. [A0A3B1DZW5-1]
DR GeneID; 186490; -.
DR KEGG; cel:CELE_F58A6.10; -.
DR UCSC; F58A6.10; c. elegans.
DR CTD; 186490; -.
DR WormBase; F58A6.10a; CE07296; WBGene00019027; srb-12. [A0A3B1DZW5-2]
DR WormBase; F58A6.10b; CE52747; WBGene00019027; srb-12. [A0A3B1DZW5-1]
DR eggNOG; ENOG502RT5J; Eukaryota.
DR GeneTree; ENSGT00970000195867; -.
DR HOGENOM; CLU_045882_1_0_1; -.
DR OMA; VYCATPT; -.
DR OrthoDB; 1114432at2759; -.
DR PRO; PR:A0A3B1DZW5; -.
DR Proteomes; UP000001940; Chromosome II.
DR GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; IEA:InterPro.
DR InterPro; IPR002184; 7TM_GPCR_serpentine_rcpt_Srb.
DR PANTHER; PTHR31216; PTHR31216; 1.
DR Pfam; PF02175; 7TM_GPCR_Srb; 1.
DR PRINTS; PR00699; TMPROTEINSRB.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Cell projection;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..350
FT /note="Serpentine receptor class beta-12"
FT /id="PRO_0000447258"
FT TOPO_DOM 1..21
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 22..42
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 43..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 58..78
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 79..103
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 104..124
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 125..141
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 142..162
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 163..189
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 190..210
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 211..243
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 244..264
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 265..282
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 283..303
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 304..350
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 97
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 277
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT VAR_SEQ 217..218
FT /note="Missing (in isoform a)"
FT /evidence="ECO:0000305"
FT /id="VSP_060171"
SQ SEQUENCE 350 AA; 40868 MW; A2D12FF5CB656C27 CRC64;
MSEANLTECE LAYQLTYHPF YMIAQFWSFF VSLLAMPSLI FFMVEKVFKL PFHGNLKFLL
VSYFIGTFLF ASIICFTFGY HFFVPFFVTS NCDLIINATL FKYGHMIALI FMTIPMILPT
AFTVERFVAL KMAHSYEHVR TLLGPVLVLV VIAIDSMFLY DIYGQEKFDK PFINFILVPA
TSALQFNSFL WYMLYLKITN FICNLILLFI HKILHQSSRY RRKNVSLSVK YEMQEISQSS
RFTLIVTFTH LLFFGWYVST ILLIRTVGPD FFRGFINYTV MRGVYCATPT YNLVIVFIGF
KALNHLNFKR NNKVQSTIQI KSTGQEGAEN YDNAISNYWD SVYTMNKSKL
