SRB16_CAEEL
ID SRB16_CAEEL Reviewed; 342 AA.
AC Q20961;
DT 08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Serpentine receptor class beta-16 {ECO:0000312|WormBase:F58A6.6};
DE Short=Protein srb-16 {ECO:0000305};
GN Name=srb-16 {ECO:0000312|WormBase:F58A6.6};
GN ORFNames=F58A6.6 {ECO:0000312|WormBase:F58A6.6};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=28662030; DOI=10.1371/journal.pbio.2002047;
RA Hoang H.D., Miller M.A.;
RT "Chemosensory and hyperoxia circuits in C. elegans males influence sperm
RT navigational capacity.";
RL PLoS Biol. 15:E2002047-E2002047(2017).
CC -!- FUNCTION: G-protein coupled receptor (Probable). Plays a role in the
CC navigational capacity of sperm and promotes the targeting of sperm
CC derived from males to the fertilization site in the uterus of
CC hermaphrodites (PubMed:28662030). {ECO:0000269|PubMed:28662030,
CC ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28662030};
CC Multi-pass membrane protein {ECO:0000255}. Perikaryon
CC {ECO:0000269|PubMed:28662030}. Cell projection, dendrite
CC {ECO:0000269|PubMed:28662030}.
CC -!- TISSUE SPECIFICITY: Expressed throughout the nervous system, in
CC pharyngeal muscle, hermaphrodite vulval muscles and in the male tail
CC (PubMed:28662030). Not expressed in male somatic gonads or sperm
CC (PubMed:28662030). {ECO:0000269|PubMed:28662030}.
CC -!- DISRUPTION PHENOTYPE: Reduced brood size, which is in part due to an
CC abnormal distribution of male-derived sperm in the hermaphrodite uterus
CC following mating, with sperm moving at a reduced velocity, reversing
CC course frequently and accumulating at the spermathecal-uterine valve 1
CC hour following mating (PubMed:28662030). No visible defects in
CC oogenesis (PubMed:28662030). {ECO:0000269|PubMed:28662030}.
CC -!- SIMILARITY: Belongs to the nematode receptor-like protein srb family.
CC {ECO:0000305}.
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DR EMBL; BX284602; CCD65837.1; -; Genomic_DNA.
DR PIR; T16496; T16496.
DR RefSeq; NP_494956.1; NM_062555.3.
DR AlphaFoldDB; Q20961; -.
DR STRING; 6239.F58A6.6; -.
DR PaxDb; Q20961; -.
DR EnsemblMetazoa; F58A6.6.1; F58A6.6.1; WBGene00019025.
DR GeneID; 186489; -.
DR KEGG; cel:CELE_F58A6.6; -.
DR UCSC; F58A6.6; c. elegans.
DR CTD; 186489; -.
DR WormBase; F58A6.6; CE04679; WBGene00019025; srb-16.
DR eggNOG; ENOG502TG49; Eukaryota.
DR GeneTree; ENSGT00970000195867; -.
DR HOGENOM; CLU_991225_0_0_1; -.
DR InParanoid; Q20961; -.
DR OMA; KLLLTMY; -.
DR OrthoDB; 1026665at2759; -.
DR PhylomeDB; Q20961; -.
DR PRO; PR:Q20961; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00019025; Expressed in larva and 3 other tissues.
DR GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; IEA:InterPro.
DR InterPro; IPR000344; 7TM_GPCR_serpentine_rcpt_Sra.
DR InterPro; IPR019408; 7TM_GPCR_serpentine_rcpt_Srab.
DR InterPro; IPR002184; 7TM_GPCR_serpentine_rcpt_Srb.
DR PANTHER; PTHR31216; PTHR31216; 1.
DR Pfam; PF10292; 7TM_GPCR_Srab; 1.
DR PRINTS; PR00697; TMPROTEINSRA.
PE 2: Evidence at transcript level;
KW Cell membrane; Cell projection; G-protein coupled receptor; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..342
FT /note="Serpentine receptor class beta-16"
FT /id="PRO_0000447260"
FT TOPO_DOM 1..22
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 23..43
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 44..61
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 62..82
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 83..102
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 103..123
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 124..141
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 142..162
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 163..187
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 188..208
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 209..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..274
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 275..295
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 296..342
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
SQ SEQUENCE 342 AA; 40001 MW; 480C39BD04CF51FD CRC64;
MDRELIEICK ENSATAFSVG YQIVYLIYVV LSVTSIFTCS YFIKTFIWNS TFHPNFKLLL
TMYFFAAIFH SFLFTASYLM MIERFLDYQT DCDIHVSMVP YAIVHSSIAC CLFCGMLTQV
FMVIERLLAT IKIESYEHNT SFWHILAYLF FCIVLPLSLL VWAYQDADYN SPVITAISPP
KGVEIRLNIL YIFCFFLAIL ALILLQVVRF VNKRRESRIE ISLSGRFQIV ENIDTTTFIS
SILIINMIMS VIYIVGTFTL RNFQFDAFIN NQPALATVKT IFYLHPLFSF LMPLISSYHL
SKMRERRVKR REHLMAIKTK GREGSDAYNQ LLHDQWTQHF LK
