SRB3_CAEEL
ID SRB3_CAEEL Reviewed; 341 AA.
AC Q95ZY2;
DT 23-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Serpentine receptor class beta-3;
DE Short=Protein srb-3;
GN Name=srb-3 {ECO:0000312|WormBase:C27D6.8};
GN ORFNames=C27D6.8 {ECO:0000312|WormBase:C27D6.8};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=28662030; DOI=10.1371/journal.pbio.2002047;
RA Hoang H.D., Miller M.A.;
RT "Chemosensory and hyperoxia circuits in C. elegans males influence sperm
RT navigational capacity.";
RL PLoS Biol. 15:E2002047-E2002047(2017).
CC -!- FUNCTION: G-protein coupled receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}. Perikaryon {ECO:0000269|PubMed:28662030}. Cell
CC projection, dendrite {ECO:0000269|PubMed:28662030}.
CC -!- TISSUE SPECIFICITY: Expressed throughout the head.
CC {ECO:0000269|PubMed:28662030}.
CC -!- SIMILARITY: Belongs to the nematode receptor-like protein srb family.
CC {ECO:0000305}.
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DR EMBL; BX284602; CCD65815.1; -; Genomic_DNA.
DR RefSeq; NP_494963.1; NM_062562.1.
DR AlphaFoldDB; Q95ZY2; -.
DR STRING; 6239.C27D6.8; -.
DR PaxDb; Q95ZY2; -.
DR EnsemblMetazoa; C27D6.8.1; C27D6.8.1; WBGene00005068.
DR GeneID; 191785; -.
DR KEGG; cel:CELE_C27D6.8; -.
DR UCSC; C27D6.8; c. elegans.
DR CTD; 191785; -.
DR WormBase; C27D6.8; CE06888; WBGene00005068; srb-3.
DR eggNOG; ENOG502RT5J; Eukaryota.
DR GeneTree; ENSGT00970000195867; -.
DR HOGENOM; CLU_045882_1_0_1; -.
DR InParanoid; Q95ZY2; -.
DR OMA; CILIKIH; -.
DR OrthoDB; 1691456at2759; -.
DR PhylomeDB; Q95ZY2; -.
DR PRO; PR:Q95ZY2; -.
DR Proteomes; UP000001940; Chromosome II.
DR GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; IEA:InterPro.
DR InterPro; IPR002184; 7TM_GPCR_serpentine_rcpt_Srb.
DR PANTHER; PTHR31216; PTHR31216; 1.
DR Pfam; PF02175; 7TM_GPCR_Srb; 1.
DR PRINTS; PR00699; TMPROTEINSRB.
PE 2: Evidence at transcript level;
KW Cell membrane; Cell projection; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..341
FT /note="Serpentine receptor class beta-3"
FT /id="PRO_0000104498"
FT TOPO_DOM 1..23
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 24..44
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 45..58
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 59..79
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 80..103
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 104..124
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 125..141
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 142..162
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 163..187
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 188..208
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 209..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..276
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 277..297
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 298..341
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 97
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 267
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 271
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ SEQUENCE 341 AA; 39665 MW; 478EAD8F0D1F0564 CRC64;
MLETNDSVCE LAYQLAYHPV YRSSQFWSML VSSLSIPALI YFITRKIFFL HFHGNLKCLL
IVYFICNLLF SMALCFAFFY QFLIPFFVTS KCQLLINTTL FKWGQICSFL LLTSSMLLPI
GFSIERFVAL GNAQKYESSR TFLGPVIIFI IIAVDFSIIF SVYKNEPFTE GFYSFILVPS
TTASQINMYF FVLLFVKIFN LLLNCILLRI HKKIRIKYYS LSVRYEMEEI LQSSKFTFII
RFTHLLFFGF YVVVILFVRI MGESFFNGTL NYSVARGVFC TVPTYNLIIV IIGIKSLRHL
NLQRLNKVQS TVQIKSTGKE GSKNYEDIIT NYWDSVSSRT P
